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A Small Molecule That Mimics the BB-loop in the Toll Interleukin-1 (IL-1) Receptor Domain of MyD88 Attenuates Staphylococcal Enterotoxin B-induced Pro-inflammatory Cytokine Production and Toxicity in Mice.
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Antisense oligonucleotide suppression of serum amyloid A reduces amyloid deposition in mice with AA amyloidosis.
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Assessing immune function by profiling cytokine release from stimulated blood leukocytes and the risk of infection in rheumatoid arthritis.
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Assessing the activity of cediranib, a VEGFR-2/3 tyrosine kinase inhibitor, against VEGFR-1 and members of the structurally related PDGFR family.
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Attenuated Abeta42 responses to low potency gamma-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds.
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Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures.
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Blood protein concentrations in the first two postnatal weeks that predict bronchopulmonary dysplasia among infants born before the 28th week of gestation.
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Blood protein concentrations in the first two postnatal weeks associated with early postnatal blood gas derangements among infants born before the 28th week of gestation. The ELGAN Study.
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Blood protein profiles of infants born before 28th week differ by pregnancy complication.
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BRI2 regulates ß-amyloid degradation by increasing levels of secreted insulin degrading enzyme (IDE).
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CAF05: cationic liposomes that incorporate synthetic cord factor and poly(I:C) induce CTL immunity and reduce tumor burden in mice.
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Can emerging biomarkers of myocardial remodelling identify asymptomatic hypertensive patients at risk for diastolic dysfunction and diastolic heart failure?
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Cardioprotection against ischaemia induced by dobutamine stress using glucagon-like peptide-1 in patients with coronary artery disease.
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CD74 deficiency ameliorates Pseudomonas aeruginosa-induced ocular infection.
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Cerebrospinal fluid microglial markers in Alzheimer's disease: elevated chitotriosidase activity but lack of diagnostic utility.
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Cerebrospinal Fluid Biomarkers for Alzheimer's Disease: Diagnostic Performance in a Homogeneous Mono-Center Population.
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Characterization Of Specific Antibodies Against Cytomegalovirus-Encoded IL-10 Produced By 28% Of The CMV-Seropositive Blood Donors.
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Chronic Antagonism of the Mineralocorticoid Receptor Ameliorates Hypertension and End Organ Damage in a Rodent Model of Salt-Sensitive Hypertension.
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Cigarette smoke increases TLR4 and TLR9 expression and induces cytokine production from CD8+ T cells in chronic obstructive pulmonary disease.
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Cluster Analysis of Placental Inflammatory Proteins Can Distinguish Preeclampsia from Preterm Labor and Premature Membrane Rupture in Singleton Deliveries Less Than 28 Weeks of Gestation.
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Comparison of a New Multiplex Binding Assay versus the Enzyme-Linked Immunosorbent Assay for Measurement of Serotype-Specific Pneumococcal Capsular Polysaccharide IgG.
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Comparison of immunosorbent assays for the quantification of biomarkers for Alzheimer's disease in human cerebrospinal fluid.
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Comparison of the effects of n-3 long chain polyunsaturated fatty acids and fenofibrate on markers of inflammation and vascular function, and on the serum lipoprotein profile in overweight and obese subjects.
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Comparison of the course of biomarker changes and kidney injury in a rat model of drug-induced acute kidney injury.
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Craniotomy: true sham for traumatic brain injury, or a sham of a sham?
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Critical role of astroglial apolipoprotein E and liver X receptor-a expression for microglial Aß phagocytosis.
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Cyst fluid interleukin-1beta (IL1beta) levels predict the risk of carcinoma in intraductal papillary mucinous neoplasms of the pancreas.
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Cytokine responses of Holstein and Sahiwal zebu derived monocytes after mycobacterial infection.
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Decreased sAßPPß, Aß38, and Aß40 Cerebrospinal Fluid Levels in Frontotemporal Dementia.
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Detection of Ricin Contamination in Ground Beef by Electrochemiluminescence Immunosorbent Assay.
Brandon, D.L. | Toxins | 2011 | View |
Development and Utilization of Activated STAT3 Detection Assays for Screening a Library of Secreted Proteins.
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Development of a multi-product leached protein A assay for bioprocess samples containing recombinant human monoclonal antibodies.
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Development of sulfonamide AKT PH domain inhibitors.
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Differential effects of HIV viral load and CD4 counts on proliferation of naive and memory CD4 and CD8 T lymphocytes.
Srinivasula, S., Lempicki, R.A., Adelsberger, J.W., Huang, C.Y., Roark, J., Lee, P.I., Rupert, A., Stevens, R., Sereti, I., Lane, H.C., Di Mascio, M., Kovacs, J.A. | Blood | 2011 | View |
Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery.
Erlanson, D.A., Arndt, J.W., Cancilla, M.T., Cao, K., Elling, R.A., English, N., Friedman, J., Hansen, S.K., Hession, C., Joseph, I., Kumaravel, G., Lee, W.C., Lind, K.E., McDowell, R.S., Miatkowski, K., Nguyen, C., Nguyen, T.B., Park, S., Pathan, N., Penny, D.M., Romanowski, M.J., Scott, D., Silvian, L., Simmons, R.L., Tangonan, B.T., Yang, W., Sun, L. | Bioorg Med Chem Lett. | 2011 | View |
Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model.
Burkholder, T.P., Clayton, J.R., Rempala, M.E., Henry, J.R., Knobeloch, J.M., Mendel, D., McLean, J.A., Hao, Y., Barda, D.A., Considine, E.L., Uhlik, M.T., Chen, Y., Ma, L., Bloem, L.J., Akunda, J.K., McCann, D.J., Sanchez-Felix, M., Clawson, D.K., Lahn, M.M., Starling, J.J. | Invest New Drugs. | 2011 | View |
Domain-based assays of individual antibody concentrations in an oligoclonal combination targeting a single protein.
Meng, Q., Li, M., Silberg, M.A., Conrad, F., Bettencourt, J., To, R., Huang, C., Ma, J., Meyer, K., Shimizu, R., Cao, L., Tomic, M.T., Marks, J.D. | Anal Biochem. | 2011 | View |
Dual IGF-I/II-Neutralizing Antibody MEDI-573 Potently Inhibits IGF Signaling and Tumor Growth.
Gao, J., Chesebrough, J.W., Cartlidge, S.A., Ricketts, S.A., Incognito, L., Veldman-Jones, M., Blakey, D.C., Tabrizi, M., Jallal, B., Trail, P.A., Coats, S., Bosslet, K., Chang, Y.S. | Cancer Res. | 2011 | View |
Duodenal-jejunal bypass protects GK rats from {beta}-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-1.
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Early postnatal blood concentrations of inflammation-related proteins and microcephaly two years later in infants born before the 28th post-menstrual week.
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Effects of peripherally administered neuromedin U on energy and glucose homeostasis.
Peier, A.M., Desai, K., Hubert, J., Du, X., Yang, L., Qian, Y., Kosinski, J.R., Metzger, J.M., Pocai, A., Nawrocki, A.R., Langdon, R.B., Marsh, D.J. | Endocrinology | 2011 | View |
Efficacy of Ganitumab (AMG 479), Alone and in Combination With Rapamycin, in Ewing's and Osteogenic Sarcoma Models.
Beltran, P.J., Chung, Y.A., Moody, G., Mitchell, P., Cajulis, E., Vonderfecht, S., Kendall, R., Radinsky, R., Calzone, F.J. | Pharmacol Exp Ther. | 2011 | View |
Endothelial dysfunction and low-grade inflammation are associated with greater arterial stiffness over a 6-year period.
van Bussel, B.C., Schouten, F., Henry, R.M., Schalkwijk, C.G., de Boer, M.R., Ferreira, I., Smulders, Y.M., Twisk, J.W., Stehouwer, C.D. | Hypertension. | 2011 | View |
Enhanced humoral and cell-mediated immune responses after immunization with trivalent influenza vaccine adjuvanted with cationic liposomes.
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Enhanced peripheral toll-like receptor responses in psychosis: further evidence of a pro-inflammatory phenotype.
McKernan, D.P., Dennison, U., Gaszner, G., Cryan, J.F., Dinan, T.G. | Translational Psychiatry | 2011 | View |
Eosinophil and neutrophil extracellular DNA traps in human allergic asthmatic airways.
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E-Selectin is Elevated in Cord Blood of South Asian Neonates Compared with Caucasian Neonates.
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Essential Role for Protein Kinase C{zeta} in Oleic Acid-Induced Glucagon-Like Peptide-1 Secretion in Vivo in the Rat.
Iakoubov, R., Ahmed, A., Lauffer, L.M., Bazinet, R.P., Brubaker, P.L. | Endocrinology | 2011 | View |
Evaluation of KRAS mutations, angiogenic biomarkers and DCE-MRI in patients with advanced non-small cell lung cancer receiving sorafenib.
Kelly, R.J., Rajan, A., Force, J., Keen, C., Cao, L., Yu, Y., Choyke, P.L., Turkbey, B., Raffeld, M., Xi, L., Steinberg, S.M., Wright, J.J., Lopez-Chavez, A., Kummar, S., Guttierrez, M., Giaccone, G. | Clin Cancer Res. | 2011 | View |
Evidence for Elevated Cerebrospinal Fluid ERK1/2 Levels in Alzheimer Dementia.
Spitzer, P., Scheib, H., Kamrowski-Kruck, H, Otto, M., Chiasserini, D., Parnetti, L., Herukka, S.K., Schuchhart, J., Wiltfang, J., Klafki, H.W. | International Journal of Alzheimer's Disease. | 2011 | View |
Exchanging Saturated Fatty Acids for (n-6) Polyunsaturated Fatty Acids in a Mixed Meal May Decrease Postprandial Lipemia and Markers of Inflammation and Endothelial Activity in Overweight Men.
Masson, C.J., Mensink, R.P. | J Nutr. | 2011 | View |
Experimental endotoxemia induces leukocyte adherence and plasma extravasation within the rat pial microcirculation.
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Exploratory analysis of early toxicity of sunitinib in advanced hepatocellular carcinoma patients: kinetics and potential biomarker value.
Zhu, A.X., Duda, D.G., Ancukiewicz, M., di Tomaso, E., Clark, J.W., Miksad, R., Fuchs, C.S., Ryan, D.P., Jain, R.K. | Clin Cancer Res. | 2011 | View |
Factors influencing the degradation of archival formalin-fixed paraffin-embedded tissue sections.
Xie, R., Chung, J.Y., Ylaya, K., Williams, R.L., Guerrero, N., Nakatsuka, N., Badie, C., Hewitt, S.M. | J Histochem Cytochem. | 2011 | View |
Familial aggregation of autoimmune disease in juvenile dermatomyositis.
Niewold, T.B., Wu, S.C., Smith, M., Morgan, G.A., Pachman, L.M. | Pediatrics | 2011 | View |
Fate of Transgenic DNA from Orally Administered Bt MON810 Maize and Effects on Immune Response and Growth in Pigs.
Walsh, M.C., Bouzuianu, S.G., Gardiner, G.E., Rea, M.C., Gelencser, E., Janosi, A., Epstein, M.M., Ross, R.P., Lawlor, P.G. | PLoS One. | 2011 | View |
Fetal exposure to chlordane and permethrin mixtures in relation to inflammatory cytokines and birth outcomes.
Neta G, Goldman LR, Barr D, Apelberg BJ, Witter FR, Halden RU. | Environ Sci Technol. | 2011 | View |
Fetal-placental inflammation, but not adrenal activation, is associated with extreme preterm delivery.
Trivedi S, Joachim M, McElrath T, Kliman HJ, Allred EN, Fichorova RN, Onderdonk A, Heitor F, Chaychi L, Leviton A, Majzoub JA; ELGAN study investigators. | Am J Obstet Gynecol. | 2011 | View |
Fish oil supplementation alters levels of lipid mediators of inflammation in microenvironment of acute human wounds.
McDaniel, J.C., Massey, K., Nicolaou, A. | Wound Repair Regen. | 2011 | View |
Functionalized Scaffold-mediated Interleukin 10 Gene Delivery Significantly Improves Survival Rates of Stem Cells In Vivo.
Holladay, C., Power, K., Sefton, M., O'Brien, T., Gallagher, W.M., Pandit, A. | Mol Ther. | 2011 | View |
GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway.
Wallin, J.J., Edgar, K.A., Guan, J., Berry, M., Prior, W.W., Lee, L., Lesnick, J.D., Lewis, C., Nonomiya, J., Pang, J., Salphati, L., Olivero, A.G., Sutherlin, D.P., O'Brien, C., Spoerke, J.M., Patel, S., Lensun, L., Kassees, R., Ross, L., Lackner, M.R., Sampath, D., Belvin, M., Friedman, L.S. | Mol Cancer Ther. | 2011 | View |
GPR119 agonists mediate GLP-1 secretion from mouse enteroendocrine cells through glucose-independent pathways.
Lan, H., Lin, H.V., Wang, C.F., Wright, M.J., Xu, S., Kang, L., Juhl, K., Hedrick, J.A., Kowalski, T.J. | Br J Pharmacol. | 2011 | View |
Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2.
Jornayvaz, F.R., Birkenfeld, A.L., Jurczak, M.J., Kanda, S., Guigni, B.A., Jiang, D.C., Zhang, D., Lee, H.Y., Samuel, V.T., Shulman, G.I. | Proc Natl Acad Sci USA. | 2011 | View |
High plasma interleukin-18 levels mark the acute phase of hepatitis C virus infection.
Chattergoon, M.A., Levine, J.S., Latanich, R., Osburn, W.O., Thomas, D.L., Cox, A.L. | J Infect Dis. | 2011 | View |
High-dose zidovudine plus valganciclovir for Kaposi sarcoma herpesvirus-associated multicentric Castleman disease: a pilot study of virus-activated cytotoxic therapy.
Uldrick, T.S., Polizzotto, M.N., Aleman, K., O'Mahony, D., Wyvill, K.M., Wang, V., Marshall, V., Pittaluga, S., Steinberg, S.M., Tosato, G., Whitby, D., Little, R.F., Yarchoan, R. | Blood | 2011 | View |
Higher Levels of CRP, D-dimer, IL-6, and Hyaluronic Acid Before Initiation of Antiretroviral Therapy (ART) Are Associated With Increased Risk of AIDS or Death.
Boulware, D.R., Hullsiek, K.H., Puronen, C.E., Rupert, A., Baker, J.V., French, M.A., Bohjanen, P.R., Novak, R.M., Neaton, J.D., Sereti, I; for the INSIGHT Study Group. | J Infect Dis. | 2011 | View |
High-Throughput Simultaneous Analysis of RNA, Protein, and Lipid Biomarkers in Heterogeneous Tissue Samples.
Reiser, V., Smith, R.C., Xue, J., Kurtz, M.M., Liu, R., Legrand, C., He, X., Yu, X., Wong, P., Hinchcliffe, J.S., Tanen, M.R., Lazar, G., Zieba, R., Ichetovkin, M., Chen, Z., O'Neill, E.A., Tanaka, W.K., Marton, M.J., Liao, J., Morris, M., Hailman, E., Tokiwa, G.Y., Plump, A.S. | Clin Chem. | 2011 | View |
Human Keratinocytes' Response to Injury Upregulates CCL20 and Other Genes Linking Innate and Adaptive Immunity.
Kennedy-Crispin, M., Billick, E., Mitsui, H., Gulati, N., Fujita, H., Gilleaudeau, P., Sullivan-Whalen, M., Johnson-Huang, L.M., Suárez-Fariñas, M., Krueger, J.G. | J Invest Dermatol. | 2011 | View |
Hypoxia-inducible factor 1{alpha} (HIF-1 {alpha}) and autophagy in polycystic kidney disease (PKD).
Belibi, F., Zafar, I., Ravichandran, K., Bauer Segvic, A., Jani, A., Ljubanovic, D.G., Edelstein, C.L. | Am J Physiol Renal Physiol. | 2011 | View |
Identification of SPARC-like Protein as Part of a Biomarker Panel for Alzheimer's Disease in Cerebrospinal Fluid.
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IL-1alpha/IL-1R1 Expression in Chronic Obstructive Pulmonary Disease and Mechanistic Relevance to Smoke-Induced Neutrophilia in Mice.
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IL-6-independent association of elevated serum neopterin levels with prevalent frailty in community-dwelling older adult.
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IL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancer.
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IL-10 Blocks Phagosome Maturation in Mycobacterium tuberculosis-infected Human Macrophages.
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Immediate and long-term effects of addition of exercise to a 16-week very low calorie diet on low-grade inflammation in obese, insulin-dependent type 2 diabetic patients.
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Immune Activation Resulting From NKG2D/Ligand Interaction Promotes Atherosclerosis.
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Immune Responses to the Enduring Hypoxic Response Antigen Rv0188 Are Preferentially Detected in Mycobacterium bovis Infected Cattle with Low Pathology.
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In Vivo and In Vitro Characterization of a First-in-Class Novel Azole Analog That Targets Pregnane X Receptor Activation.
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Increased levels of circulating interleukin 6, interleukin 8, C-reactive protein, and risk of lung cancer.
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Infant gut microbiota is protective against cow's milk allergy in mice despite immature ileal T-cell response.
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Inflammatory cytokine and chemokine expression is differentially modulated acutely in the dorsal root ganglion in response to different nerve root compressions.
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Inflammatory responses to trivalent influenza virus vaccine among pregnant women.
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Inflammatory Signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in mice.
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Inhibition of Apical Sodium-Dependent Bile Acid Transporter (Asbt) as a Novel Treatment for Diabetes.
Chen, L., Yao, X., Young, A., McNulty, J., Anderson, D., Liu, Y., Nystrom, C., Croom, D., Ross, S., Collins, J., Rajpal, D., Hamlet, K., Smith, C.D., Gedulin, B.R. | Am J Physiol Endocrinol Metab. | 2011 | View |
Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides.
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