Blood protein profiles of infants born before 28th week differ by pregnancy complication.

McElrath, T.F., Fichorova, R.N., Allred, E.N., Hecht, J.L., Ismail, M.A., Yuan, H., Leviton, A; ELGAN Study Investigators.
Journal   Am J Obstet Gynecol.
Species  
Analytes Measured   CRP , E-Selectin , I-TAC , ICAM-1 , ICAM-3 , IGFBP-1 , IL-6 , IL-6R , IL-8 , MCP-1 , MCP-4 , MMP-1 , MMP-9 , MPO , RANTES , SAA , TNF-RI , TNF-RII , VCAM-1 , Flt-1 VEGFR1
Matrix Tested   Dried blood spots
Year   2011
Volume   204
Page Numbers  
Application   Cytokines and Chemokines
Abstract

OBJECTIVE: Disorders that lead to preterm delivery influence the fetal inflammatory response.

STUDY DESIGN: We calculated odds ratios of elevated concentrations of 25 blood proteins on the first postnatal day in 798 infants born before the 28th week and classified by the pregnancy disorder that lead to preterm delivery.

RESULTS: Concentrations of cytokines (IL-1β, IL-6, TNFα), cytokine receptors (IL-6R, TNF-R1, TNF-R2), systemic inflammatory proteins (CRP, SAA, MPO), chemokines (IL-8, MCP-1, MCP-4, MIP-1β, RANTES, I-TAC), adhesion molecules (ICAM-1, ICAM-3, VCAM-1, E-selectin), and metalloproteinases (MMP-1, MMP-9) were elevated in children delivered after preterm labor, membrane rupture, abruption, and cervical insufficiency, whereas such a pattern was not seen after preeclampsia or fetal indication/growth restriction. Inflammatory profiles were also associated with maternal vaginitis.

CONCLUSION: The patterns of blood proteins in the newborn support the division of pregnancy disorders that lead to preterm delivery into those associated, and those not associated, with inflammation.

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