Abnormal peripheral chemokine profile in Huntington’s disease.

Wild, E., Magnusson, A., Lahiri, N., Krus, U., Orth, M., Tabrizi, S.J., Bjorkqvist, M.
Journal   PLoS Curr.
Species  
Analytes Measured   Eotaxin , Eotaxin-3 , IP-10 , MCP-1 , MCP-4 , MDC , TARC
Matrix Tested   Plasma
Year   2011
Volume   3
Page Numbers   RRN1231
Application   Cytokines and Chemokines
Abstract
Huntington’s disease (HD) is an inherited neurodegenerative disorder characterized by both neurological and systemic abnormalities. Immune activation is a well-established feature of the HD brain and we have previously demonstrated a widespread, progressive innate immune response detectable in plasma throughout the course of HD. In the present work we used multiplex ELISA to quantify levels of chemokines in plasma from controls and subjects at different stages of HD. We found an altered chemokine profile tracking with disease progression, with significant elevations of five chemokines (eotaxin-3, MIP-1β, eotaxin, MCP-1 and MCP-4) while three (eotaxin-3, MIP-1β and eotaxin) showed significant linear increases across advancing disease stages. We validated our results in a separate sample cohort including subjects at different stages of HD. Here we saw that chemokine levels (MCP-1 and eotaxin) correlated with clinical scores. We conclude that, like cytokines, chemokines may be linked to the pathogenesis of HD, and that immune molecules may be valuable in tracking and exploring the pathogenesis of HD

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Singleplex
V-PLEX Plus Chemokine Panel 1 NHP Kit
Eotaxin-3, IL-8, IL-8 (HA), IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, TARC | Non-human primate
Multiplex
V-PLEX Plus NHP Cytokine 24-Plex Kit
Eotaxin-3, GM-CSF, IFN-γ, IL-1β, IL-2, IL-5, IL-6, IL-7, IL-8, IL-8 (HA), IL-10, IL-12/IL-23p40, IL-15, IL-16, IL-17A, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, TARC, TNF-β, VEGF-A | Non-human primate
Multiplex
V-PLEX Plus NHP Eotaxin-3 Kit
Eotaxin-3 | Non-human primate
Singleplex
V-PLEX Plus NHP IP-10 Kit
IP-10 | Non-human primate
Singleplex
V-PLEX Plus NHP MCP-1 Kit
MCP-1 | Non-human primate
Singleplex
V-PLEX Plus NHP MCP-4 Kit
MCP-4 | Non-human primate
Singleplex
V-PLEX Plus NHP MDC Kit
MDC | Non-human primate
Singleplex
V-PLEX Plus NHP TARC Kit
TARC | Non-human primate
Singleplex
Human Eotaxin Antibody
Eotaxin
Human Eotaxin-3 Antibody
Eotaxin-3
Human IP-10 Antibody
IP-10
Human MCP-1 Antibody
MCP-1
Human MCP-4 Antibody
MCP-4
Human MDC Antibody
MDC
Human TARC Antibody
TARC
V-PLEX Chemokine Panel 1 Human Kit
Eotaxin, Eotaxin-3, IL-8, IL-8 (HA), IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, TARC | Human
Multiplex
V-PLEX Human Cytokine 30-Plex Kit
Eotaxin, Eotaxin-3, GM-CSF, IFN-γ, IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-8 (HA), IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, TARC, TNF-α, TNF-β, VEGF-A | Human
Multiplex
V-PLEX Human Eotaxin Kit
Eotaxin | Human
Singleplex
V-PLEX Human Eotaxin-3 Kit
Eotaxin-3 | Human
Singleplex
V-PLEX Human IP-10 Kit
IP-10 | Human
Singleplex
V-PLEX Human MCP-1 Kit
MCP-1 | Human
Singleplex
V-PLEX Human MCP-4 Kit
MCP-4 | Human
Singleplex
V-PLEX Human MDC Kit
MDC | Human
Singleplex
V-PLEX Human TARC Kit
TARC | Human
Singleplex
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