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Changes in Amyloid-β and Tau in the Cerebrospinal Fluid of Transgenic Mice Overexpressing Amyloid Precursor Protein. Maia LF, Kaeser SA, Reichwald J, Hruscha M, Martus P, Staufenbiel M, Jucker M. | Sci Transl Med. | 2013 | View |
Chronic TLR signaling impairs the long-term repopulating potential of hematopoietic stem cells of wild type but not Id1 deficient mice Zhao Y, Ling F, Wang H, Sun X. | PLoS One | 2013 | View |
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Deletion of the gene encoding calcitonin and CGRPα does not affect the outcome of severe infection in mice. Tuvim MJ, Clement CG, Huang ES, Cote GJ, Evans SE, Lei X, Deftos LJ, Gagel RF, Dickey BF. | Am J Respir Cell Mol Biol | 2013 | View |
Development of novel in vivo chemical probes to address CNS protein kinase involvement in synaptic dysfunction. Watterson DM, Grum-Tokars VL, Roy SM, Schavocky JP, Bradaric BD, Bachstetter AD, Xing B, Dimayuga E, Saeed F, Zhang H, Staniszewski A, Pelletier JC, Minasov G, Anderson WF, Arancio O, van Eldik LJ. | PLoS One | 2013 | View |
Diacylglycerol Acyltransferase-1 (DGAT1) inhibition perturbs postprandial gut hormone release. Lin HV, Chen D, Shen Z, Zhu L, Ouyang X, Vongs A, Kan Y, Levorse JM, Kowalik EJ Jr, Szeto DM, Yao X, Xiao J, Chen S, Liu J, Garcia-Calvo M, Shin MK, Pinto S. | PLoS One | 2013 | View |
Differences in respiratory syncytial virus and influenza infection in a house dust mite induced asthma mouse model: consequences for steroid sensitivity. Mori H, Parker NS, Rodrigues D, Hulland K, Chappell D, Hincks JS, Bright H, Evans SM, Lamb DJ. | Clin Sci (Lond). | 2013 | View |
Dual blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK/ERK (AZD6244) pathways synergistically inhibits rhabdomyosarcoma cell growth in vitro and in vivo. Renshaw J, Taylor KR, Bishop R, Valenti M, De Haven Brandon A, Gowan S, Eccles SA, Ruddle R, Johnson LD, Raynaud FI, Selfe J, Thway K, Pietsch T, Pearson AD, Shipley J. | Clin Cancer Res. | 2013 | View |
Effect of Linezolid on clinical severity and pulmonary cytokines in a murine model of Influenza A and Staphylococcus aureus coinfection. Liu X, He Y, Xiao K, White JR, Fusco DN, Papanicolaou GA | PLoS One | 2013 | View |
Effects of Lactobacillus helveticus on murine behavior are dependent on diet and genotype and correlate with alterations in the gut microbiome. Ohland CL, Kish L, Bell H, Thiesen A, Hotte N, Pankiv E, Madsen KL. | Psychoneuroendocrinology | 2013 | View |
Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency. Mokadem M, Zechner JF, Margolskee RF, Drucker DJ, Aguirre V. | Molecular Metabolism | 2013 | View |
Engagement of Two Distinct Binding Domains on CCL17 Is Required for Signaling through CCR4 and Establishment of Localized Inflammatory Conditions in the Lung. Santulli-Marotto S, Boakye K, Lacy E, Wu S, Luongo J, Kavalkovich K, Coelho A, Hogaboam CM, Ryan M. | PLoS One | 2013 | View |
Enhanced proteolytic clearance of plasma Aβ by peripherally administered neprilysin does not result in reduced levels of brain Aβ in mice. Walker JR, Pacoma R, Watson J, Ou W, Alves J, Mason DE, Peters EC, Urbina HD, Welzel G, Althage A, Liu B, Tuntland T, Jacobson LH, Harris JL, Schumacher AM. | J Neurosci | 2013 | View |
Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo. Rezania A, Bruin JE, Xu J, Narayan K, Fox JK, O'Neil JJ, Kieffer TJ. | Stem Cells | 2013 | View |
Epigenetic induction of EGR-1 expression by the amyloid precursor protein during exposure to novelty. Hendrickx A, Pierrot N, Tasiaux B, Schakman O, Brion JP, Kienlen-Campard P, De Smet C, Octave JN. | PLoS One | 2013 | View |
Evaluation of immunogenicity and protective efficacy of orally delivered Shigella type III secretion system proteins IpaB and IpaD. Heine SJ, Diaz-McNair J, Martinez-Becerra FJ, Choudhari SP, Clements JD, Picking WL, Pasetti MF. | Vaccine | 2013 | View |
Evaluation of the stability, bioavailability, and hypersensitivity of the omega-3 derived anti-leukemic prostaglandin: δ(12)-prostaglandin j3. Kudva AK, Kaushal N, Mohinta S, Kennett MJ, August A, Paulson RF, Prabhu KS. | PLoS One | 2013 | View |
Fibroblast growth factor 21 mediates specific glucagon actions. Habegger KM, Stemmer K, Cheng C, Müller TD, Heppner KM, Ottaway N, Holland J, Hembree JL, Smiley D, Gelfanov V, Krishna R, Arafat AM, Konkar A, Belli S, Kapps M, Woods SC, Hofmann SM, D'Alessio D, Pfluger PT, Perez-Tilve D, Seeley RJ, Konishi M, et al. | Diabetes | 2013 | View |
Fundamental role for HIF-1α in constitutive expression of human β defensin-1. Kelly CJ, Glover LE, Campbell EL, Kominsky DJ, Ehrentraut SF, Bowers BE, Bayless AJ, Saeedi BJ, Colgan SP. | Mucosal Immunol | 2013 | View |
Gamma-Secretase Inhibitor Activity of a Pterocarpus erinaceus Extract. Hage S, Marinangeli C, Stanga S, Octave JN, Quetin-Leclercq J, Kienlen-Campard P. | Neurodegener Dis. | 2013 | View |
Glucagon-like peptide-1 receptor agonist treatment reduces beta cell mass in normoglycaemic mice. Ellenbroek JH, Töns HA, Westerouen van Meeteren MJ, de Graaf N, Hanegraaf MA, Rabelink TJ, Carlotti F, de Koning EJ. | Diabetologia | 2013 | View |
GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes. Nohr MK, Pedersen MH, Gille A, Egerod KL, Engelstoft MS, Husted AS, Sichlau RM, Grunddal KV, Seier Poulsen S, Han S, Jones RM, Offermanns S, Schwartz TW. | Endocrinology | 2013 | View |
Heparanase mediates renal dysfunction during early sepsis in mice. Lygizos MI, Yang Y, Altmann CJ, Okamura K, Hernando AA, Perez MJ, Smith LP, Koyanagi DE, Gandjeva A, Bhargava R, Tuder RM, Faubel S, Schmidt EP. | Physiol Rep. | 2013 | View |
High-fat feeding rapidly induces obesity and lipid derangements in C57BL/6N mice. Podrini C, Cambridge EL, Lelliott CJ, Carragher DM, Estabel J, Gerdin AK, Karp NA, Scudamore CL; Sanger Mouse Genetics Project, Ramirez-Solis R, White JK. | Mamm Genome | 2013 | View |
HMGB1 mediates splenomegaly and expansion of splenic CD11b+ Ly-6Chigh inflammatory monocytes in murine sepsis survivors. Valdés-Ferrer SI, Rosas-Ballina M, Olofsson PS, Lu B, Dancho ME, Ochani M, Li JH, Scheinerman JA, Katz DA, Levine YA, Hudson LK, Yang H, Pavlov VA, Roth J, Blanc L, Antoine DJ, Chavan SS, Andersson U, Diamond B, Tracey KJ. | J Intern Med. | 2013 | View |
IFN-γ production by amyloid β-specific Th1 cells promotes microglial activation and increases plaque burden in a mouse model of Alzheimer's disease. Browne TC, McQuillan K, McManus RM, O'Reilly JA, Mills KH, Lynch MA. | J Immunol | 2013 | View |
IL-33 is more potent than IL-25 in provoking IL-13-producing nuocytes (type 2 innate lymphoid cells) and airway contraction. Barlow JL, Peel S, Fox J, Panova V, Hardman CS, Camelo A, Bucks C, Wu X, Kane CM, Neill DR, Flynn RJ, Sayers I, Hall IP, McKenzie AN. | J Allergy Clin Immunol. | 2013 | View |
Immune enhancing properties of the novel Matrix-M™ adjuvant leads to potentiated immune responses to an influenza vaccine in mice. Magnusson SE, Reimer JM, Karlsson KH, Lilja L, Bengtsson KL, Stertman L. | Vaccine | 2013 | View |
Immunomodulation targeting of both Aβ and tau pathological conformers ameliorates Alzheimer's disease pathology in TgSwDI and 3xTg mouse models. Goni F, Herline K, Peyser D, Wong K, Ji Y, Sun Y, Mehta P, Wisniewski T. | J Neuroinflammation | 2013 | View |
Increased misfolding and truncation of tau in APP/PS1/tau transgenic mice compared to mutant tau mice. Heraud C, Goufak D, Ando K, Leroy K, Suain V, Yilmaz Z, De Decker R, Authelet M, Laporte V, Octave JN, Brion JP. | Neurobiol Dis. | 2013 | View |
Inhibition of nuclear factor of activated T-cells (NFAT) suppresses accelerated atherosclerosis in diabetic mice. Zetterqvist AV, Berglund LM, Blanco F, Garcia-Vaz E, Wigren M, Dunér P, Andersson AM, To F, Spegel P, Nilsson J, Bengtsson E, Gomez MF. | PLoS One | 2013 | View |
Intracranial injection of Gammagard, a human IVIg, modulates the inflammatory response of the brain and lowers Aβ in APP/PS1 mice along a different time course than anti-Aβ antibodies. Sudduth TL, Greenstein A, Wilcock DM. | J Neurosci. | 2013 | View |
Lipopolysaccharide-induced inflammation aggravates irradiation-induced injury to the young mouse brain. Roughton K, Andreasson U, Blomgren K, Kalm M. | Dev Neurosci. | 2013 | View |
Mice lacking epithelial I-κB kinase are protected from lipopolysaccharide and cigarette smoke extract induced inflammation. Lamb D, Parker N, Ulrich K, Jones G, Apfeldorfer C, Pasparakis M, Evans S, Kilty I. | J Pulmon Resp Med | 2013 | View |
Microchannel acoustophoresis does not impact survival or function of microglia, leukocytes or tumor cells. Burguillos MA, Magnusson C, Nordin M, Lenshof A, Augustsson P, Hansson MJ, Elmér E, Lilja H, Brundin P, Laurell T, Deierborg T. | PLoS One. | 2013 | View |
Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease. Lucin KM, O'Brien CE, Bieri G, Czirr E, Mosher KI, Abbey RJ, Mastroeni DF, Rogers J, Spencer B, Masliah E, Wyss-Coray T. | Neuron | 2013 | View |
Multimodal microvascular imaging reveals that selective inhibition of class I PI3K is sufficient to induce an antivascular response. Sampath D, Oeh J, Wyatt SK, Cao TC, Koeppen H, Eastham-Anderson J, Robillard L, Ho CC, Ross J, Zhuang G, Reslan HB, Vitorino P, Barck KH, Ungersma SE, Vernes JM, Caunt M, Van Bruggen N, Ye W, Vijapurkar U, Meng YJ, Ferrara N, Friedman LS, Carano RA. | Neoplasia | 2013 | View |
New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF. Yang T, Hong S, O'Malley T, Sperling RA, Walsh DM, Selkoe DJ. | Alzheimers Dement | 2013 | View |
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT. | Nature | 2013 | View |
Nucleotide-binding oligomerization domain 2 signaling promotes hyperresponsive macrophages and colitis in IL-10-deficient mice. Jamontt J, Petit S, Clark N, Parkinson SJ, Smith P. | J Immunol | 2013 | View |
Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor. Diakogiannaki E, Pais R, Tolhurst G, Parker HE, Horscroft J, Rauscher B, Zietek T, Daniel H, Gribble FM, Reimann F. | Diabetologia | 2013 | View |
Oral tungstate (Na2WO4) exposure reduces adaptive immune responses in mice after challenge. Osterburg AR, Robinson CT, Mokashi V, Stockelman M, Schwemberger SJ, Chapman G, Babcock GF. | J Immunotoxicol. | 2013 | View |
Parenteral immunization with IpaB/IpaD protects mice against lethal pulmonary infection by Shigella. Martinez-Becerra FJ, Scobey M, Harrison K, Choudhari SP, Quick AM, Joshi SB, Middaugh CR, Picking WL. | Vaccine | 2013 | View |
Preclinical Evaluation of the Toxicological Effects of a Novel Constrained Ethyl Modified Antisense Compound Targeting Signal Transducer and Activator of Transcription 3 in Mice and Cynomolgus Monkeys. Burel SA, Han SR, Lee HS, Norris DA, Lee BS, Machemer T, Park SY, Zhou T, He G, Kim Y, MacLeod AR, Monia BP, Lio S, Kim TW, Henry SP. | Nucleic Acid Ther. | 2013 | View |
Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells. Chen X, Chang J, Deng Q, Xu J, Nguyen TA, Martens LH, Cenik B, Taylor G, Hudson KF, Chung J, Yu K, Yu P, Herz J, Farese RV Jr, Kukar T, Tansey MG. | J Neurosci. | 2013 | View |
Quinine controls body weight gain without affecting food intake in male C57BL6 mice. Cettour-Rose P, Bezençon C, Darimont C, le Coutre J, Damak S. | BMC Physiol | 2013 | View |
Reductions in serum IGF-1 during aging impair health span. Gong Z, Kennedy O, Sun H, Wu Y, Williams GA, Klein L, Cardoso L, Matheny RW Jr, Hubbard GB, Ikeno Y, Farrar RP, Schaffler MB, Adamo ML, Muzumdar RH, Yakar S. | Aging Cell | 2013 | View |
Requirement of apoptosis-inducing kinase 1 for the induction of bronchial asthma following stimulation with ovalbumin. Takada E. Furuhata M, Nakae S, Ichijo H, Sudo K, Mizuguchi J. | Int Arch Allergy Immunol. | 2013 | View |
Resveratrol protects against atherosclerosis, but does not add to the antiatherogenic effect of atorvastatin, in APOE*3-Leiden.CETP mice. Berbée JF, Wong MC, Wang Y, van der Hoorn JW, Khedoe PP, van Klinken JB, Mol IM, Hiemstra PS, Tsikas D, Romijn JA, Havekes LM, Princen HM, Rensen PC. | J Nutr Biochem. 2013 Aug;24(8):1423-30 | 2013 | View |
S49076 is a novel kinase inhibitor of MET, AXL and FGFR with strong preclinical activity alone and in association with bevacizumab. Burbridge MF, Bossard CJ, Saunier C, Fejes I, Bruno A, Leonce S, Ferry G, Da Violante G, Bouzom F, Cattan V, Jacquet-Bescond A, Comoglio PM, Lockhart BP, Boutin JA, Cordi A, Ortuno JC, Pierre A, Hickman JA, Cruzalegui FH, Depil S. | Mol Cancer Ther. | 2013 | View |
Shedding LIGHT (TNFSF14) on the tumor microenvironment of colorectal cancer liver metastases. Qin JZ, Upadhyay V, Prabhakar B, Maker AV. | J Transl Med | 2013 | View |
T Cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia. Fogli LK, Sundrud MS, Goel S, Bajwa S, Jensen K, Derudder E, Sun A, Coffre M, Uyttenhove C, Van Snick J, Schmidt-Supprian M, Rao A, Grunig G, Durbin J, Casola SS, Rajewsky K, Koralov SB. | J Immunol. | 2013 | View |
Targeting IGF-IR with ganitumab inhibits tumorigenesis and increases durability of response to androgen-deprivation therapy in VCaP prostate cancer xenografts. Fahrenholtz CD, Beltran PJ, Burnstein KL. | Mol Cancer Ther | 2013 | View |
The absence of mrp4 has no effect on the recruitment of neutrophils and eosinophils into the lung after LPS, cigarette smoke or allergen challenge. Schymeinsky J, Mayer H, Tomsic C, Tilp C, Schuetz JD, Cui Y, Wollin L, Gantner F, Erb KJ. | PLoS One | 2013 | View |
The discovery of a reciprocal relationship between tyrosine-kinase signaling and cullin neddylation. Friend SF, Peterson LK, Treacy E, Stefanski AL, Sosinowski T, Pennock ND, Berger AJ, Winn VD, Dragone LL. | PLoS One | 2013 | View |
The effects of interleukin-6 signal blockade on immune system, reproductive and skeletal development in juvenile mice. Sakurai T, Takai R, Bürgin H, Shioda A, Sakamoto Y, Amano J, Grimm HP, Richter WF, Higuchi Y, Chiba S, Kawamura A, Suzuki M, Müller L. | Birth Defects Res B Dev Reprod Toxicol. | 2013 | View |
The p38α MAPK regulates microglial responsiveness to diffuse traumatic brain injury. Bachstetter AD, Rowe RK, Kaneko M, Goulding D, Lifshitz J, Van Eldik LJ. | J Neurosci. | 2013 | View |
The roles of IRF-3 and IRF-7 in innate antiviral immunity against dengue virus. Chen HW, King K, Tu J, Sanchez M, Luster AD, Shresta S. | J Immunol | 2013 | View |
The type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brain. Parthsarathy V, Holscher C. | Eur J Pharmacol | 2013 | View |
TLR3, TRIF, and Caspase 8 determine double-stranded RNA-induced epithelial cell death and survival in vivo. McAllister CS, Lakhdari O, Pineton de Chambrun G, Gareau MG, Broquet A, Lee GH, Shenouda S, Eckmann L, Kagnoff MF. | J Immunol | 2013 | View |
Transgenic expression of β1 antibody in brain neurons impairs age-dependent amyloid deposition in APP23 mice. Paganetti P, Reichwald J, Bleckmann D, Abramowski D, Ammaturo D, Barske C, Danner S, Molinari M, Müller M, Papin S, Rabe S, Schmid P, Staufenbiel M. | Neurobiol Aging | 2013 | View |
Vascular endothelial growth factor-D-mediated blockade of regulatory T cells within tumors is induced by hematopoietic stem cell transplantation. Udagawa T, Narumi K, Suzuki K, Aida K, Miyakawa R, Ikarashi Y, Makimoto A, Chikaraishi T, Yoshida T, Aoki K. | J Immunol. | 2013 | View |
2-Aminoadipic acid is a biomarker for diabetes risk. Wang TJ, Ngo D, Psychogios N, Dejam A, Larson MG, Vasan RS, Ghorbani A, O'Sullivan J, Cheng S, Rhee EP, Sinha S, McCabe E, Fox CS, O'Donnell CJ, Ho JE, Florez JC, Magnusson M, Pierce KA, Souza AL, Yu Y, Carter C, Light PE, Melander O, Clish CB, Gerszten R | J Clin Invest. | 2012 | View |
A(2B)AR expression in non-immune cells plays an important role in the development of murine colitis. Ingersoll SA, Laroui H, Kolachala VL, Wang L, Garg P, Denning TL, Gewirtz AT, Merlin D, Sitaraman SV. | Dig Liver Dis. | 2012 | View |
Acute systemic and lung inflammation in C57Bl/6J mice after intratracheal aspiration of particulate matter from small-scale biomass combustion appliances based on old and modern technologies. Uski OJ, Happo MS, Jalava PI, Brunner T, Kelz J, Obernberger I, Jokiniemi J, Hirvonen MR. | Inhal Toxicol. 2012 Dec;24(14):952-65. | 2012 | View |
Adora2b Adenosine Receptor Signaling Protects during Acute Kidney Injury via Inhibition of Neutrophil-Dependent TNF-α Release. Grenz A, Kim JH, Bauerle JD, Tak E, Eltzschig HK, Clambey ET. | J Immunol. | 2012 | View |
Allergy influences the inflammatory status of the brain and enhances tau phosphorylation. Sarlus H, Höglund CO, Karshikoff B, Wang X, Lekander M, Schultzberg M, Oprica M. | J Cell Mol Med. | 2012 | View |
Anti-inflammatory effects of Lacto-Wolfberry in a mouse model of experimental colitis. Philippe D, Brahmbhatt V, Foata F, Saudan Y, Serrant P, Blum S, Benyacoub J, Vidal K. | World J Gastroenterol. | 2012 | View |
Arachidonate 15-Lipoxygenase Type B Knockdown Leads to Reduced Lipid Accumulation and Inflammation in Atherosclerosis. Magnusson, LU, Lundqvist A, Karlsson MN, Skalen K, Levin M, Wiklund O, Boren J, Hulten LM. | PLoS One | 2012 | View |