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Electrochemiluminescent immunoassay for rat skeletal troponin I (Tnni2) in serum. Sun, D., Hamlin, D., Butterfield, A., Watson, D.E., Smith, H.W. | J Pharmacol Toxicol Methods. | 2009 | View |
Evaluation of the usefulness of biomarkers for cardiac and skeletal myotoxicity in rats. Tonomura, Y., Mori, Y., Torii, M., Uehara, T. | Toxicology. | 2009 | View |
Fenton chemistry and oxidative stress mediate the toxicity of the ß-amyloid peptide in a Drosophila model of Alzheimer's disease. Rival, R., Page, R.M., Chandraratna, D.S., Sendall, T.J., Ryder, E., Liu, B., Lewis, H., Rosahl, T., Hider, R., Camargo, L.M., Shearman, M.S., Crowther, D.C., Lomas, D.A. | Eur J Nuroscience. | 2009 | View |
Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Grathwohl, S.A., Kälin, R.E., Bolmont, T., Prokop, S., Winkelmann, G., Kaeser, S.A., Odenthal, J., Radde, R., Eldh, T., Gandy, S., Aguzzi, A., Staufenbiel, M., Mathews, P.M., Wolburg,H., Heppner, F.L., Jucker, M. | Nat Neurosci. | 2009 | View |
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γ-Secretase-dependent cleavage of amyloid precursor protein regulates osteoblast behavior. McLeod, J., Curtis, N., Lewis, H.D., Good, M.A., Fagan, M.J., Genever, P.G. | FASEB J | 2009 | View |
Generation of an epigenetic signature by chronic hypoxia in prostate cells. Watson, J.A., Watson, C.J., McCrohan, A.M., Woodfine, K., Tosetto, M., McDaid, J., Gallagher, E., Betts, D., Baugh, J., O'Sullivan, J., Murrell, A., Watson, R.W., McCann, A. | Human Molecular Genetics. | 2009 | View |
GPR119 is essential for oleoylethanolamide-induced glucagon-like peptide-1 secretion from the intestinal enteroendocrine L-cell. Lauffer, L.M., Iakoubov, R., Brubaker, P.L. | Diabetes | 2009 | View |
High sensitivity cytokine detection in acute coronary syndrome reveals up-regulation of Interferon Gamma and Interleukin-10 post Myocardial Infarction. Patel, K.D., Duggan, S.P., Currid, C.A., Gallagher, W.M., McManus, R., Kelleher, D., Murphy, R.T., Ryan, A.W. | Clinical Immunology. | 2009 | View |
High throughput evaluation of gamma-H2AX. Avondoglio, D., Scott, T., Kil, W.J., Sproull, M., Tofilon, P.J., Camphausen, K. | Radiation Oncology. | 2009 | View |
High-Throughput Protein-Based Technologies and Computational Models for Drug Development, Efficacy, and Toxicity in Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools. Alexopoulos, L.G., Saez-Rodriguez, J., Espelin, C.W. | Ed. Ekins, S. Wiley InterScience. | 2009 | View |
Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2. Hasumi, Y., Baba, M., Ajima, R., Hasumi, H., Valera, V.A., Klein, M.E., Haines, D.C., Merino, M.J., Hong, S.B., Yamaguchi, T.P., Schmidt, L.S., Linehan, W.M. | Proc Natl Acad Sci USA. | 2009 | View |
Human dendritic cell maturation and activation by a heat-killed recombinant yeast (Saccharomyces cerevisiae) vector encoding carcinoembryonic antigen. Remondo, C., Cereda, V., Mostbock, S., Sabzevari, H., Franzusoff, A., Schlom, J., Tsang, K.Y. | Vaccine. | 2009 | View |
Human pharmacokinetics/pharmacodynamics of an interleukin-4 and interleukin-13 dual antagonist in asthma. Getz, E.B., Fisher, D.M., Fuller, R. | J Clin Pharmacol. | 2009 | View |
Identification of novel N-terminal fragments of amyloid precursor protein in cerebrospinal fluid. Portelius, E., Brinkmalm, G., Tran, A., Andreasson, U., Zetterberg, H., Westman-Brinkmalm, A., Blennow, K., Ohrfelt, A. | Experimental Neurology | 2009 | View |
IL-13 expression by blood T cells and not eosinophils is increased in asthma compared to non-asthmatic eosinophilic bronchitis. Siddiqui, S., Cruse, G., McKenna, S., Monteiro, W., Mistry, V., Wardlaw, A., Brightling, C. | BMC Pulmonary Medicine. | 2009 | View |
Immunomodulatory drugs reorganize cytoskeleton by modulating Rho GTPases. Xu, Y., Li, J., Ferguson, G.D., Mercurio, F., Khambatta, G., Morrison, L. Lopez-Girona, A., Corral, L.G., Webb, D.R., Bennett, B.L., Xie, W. | Blood | 2009 | View |
Increased levels of inflammatory chemokines in amyotrophic lateral sclerosis. Kuhle, J., Lindberg, R.L., Regeniter, A., Mehling, M., Steck, A.J., Kappos, L, Czaplinski, A. | Eur J of Neurology. | 2009 | View |
Increased numbers of motor activity peaks during light cycle are associated with reductions in adrenergic alpha(2)-receptor levels in a transgenic Huntington's disease rat model. Bode, F.J., Stephan, M., Wiehager, S., Nguyen, H.P., Björkqvist, M., von Hörsten, S., Bauer, A., Petersén, A. | Behav Brain Res | 2009 | View |
Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo Fujita, Y., Wideman, R.D., Speck, M., Asadi, A., King, D.S., Webber, T.D., Haneda, M., Kieffer, T.J. | Am J Physiol Endocrinol Metab. | 2009 | View |
Indoleamine 2,3-dioxygenase-expressing mature human monocyte-derived dendritic cells expand potent autologous regulatory T cells. Chung, D.J., Rossi, M., Romano, E., Ghith, J., Yuan, J., Munn, D.H., Young, J.W. | Blood | 2009 | View |
Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation. Eisele, Y.S., Bolmont, T., Heikenwalder, M., Langer, F., Jacobson, L.H., Yan, Z.X., Roth, K., Aguzzi, A., Staufenbiel, M., Walker, L.C., Jucker, M. | Proc Natl Acad Sci U S A. | 2009 | View |
Inflammation-associated serum and colon markers as indicators of dietary attenuation of colon carcinogenesis in ob/ob mice. Mentor-Marcel, R.A., Bobe, G., Barrett, K.G., Young, M.R., Albert, P.S., Bennink, M.R., Lanza, E., Colburn, N.H. | Cancer Prev Res. | 2009 | View |
Inhibition of Siah2 ubiquitin ligase by vitamin K3 (menadione) attenuates hypoxia and MAPK signaling and blocks melanoma tumorigenesis. Shah, M., Stebbins, J.L., Dewing, A., Qi, J., Pellecchia, M., Ronai, Z.A. | | 2009 | View |
Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell. Lim, G.E., Huang, G.J., Flora, N., Leroith, D., Rhodes, C.J., Brubaker, P.L. | Endocrinology | 2009 | View |
Interleukin-6 Is Elevated in the Cerebrospinal Fluid of Suicide Attempters and Related to Symptom Severity. Lindqvist, D., Janelidze, S., Hagell, P., Erhardt, S., Samuelsson, M., Minthon, L., Hansson, O., Björkqvist, M., Träskman-Bendz, L., Brundin, L. | Biol Psychiatry. | 2009 | View |
Involvement of T helper type 17 and regulatory T cell activity in Citrobacter rodentium invasion and inflammatory damage. Symonds, E.L., Riedel, C.U., O'Mahony, D., Lapthorne, S., O'Mahony, L., Shanahan, F. | Clinical & Experimental Immunology. | 2009 | View |
Lack of detection of agonist activity by antibodies to platelet-derived growth factor receptor alpha in a subset of normal and systemic sclerosis patient sera. Loizos, N., Lariccia, L., Weiner, J., Griffith, H., Boin, F., Hummers, L., Wigley, F., Kussie, P. | Arthritis Rheum. | 2009 | View |
Ligation of TLR9 induced on human IL-10-secreting Tregs by 1alpha,25-dihydroxyvitamin D3 abrogates regulatory function. Urry, Z., Xystrakis, E., Richards, D.F., McDonald, J., Sattar, Z., Cousins, D.J., Corrigan, C.J., Hickman, E., Brown, Z., Hawrylowicz, C.M. | J Clin Invest. | 2009 | View |
Longitudinal cytokine expression during IMRT for prostate cancer and acute treatment toxicity. Christensen, E., Pintilie, M., Evans, K.R., Lenarduzzi, M., Menard, C., Catton, C.N., Diamandis, E.P., Bristow, R.G. | Clin Cancer Res. | 2009 | View |
Matrix metalloproteinases: discrete elevations in essential hypertension and hypertensive end-stage renal disease. Friese, R.S., Rao, F., Khandrika, S., Thomas, B., Ziegler, M.G., Schmid-Schönbein, G.W., O'Connor, D.T. | Clin Exp Hypertens. | 2009 | View |
Measurement of ERK 1/2 in CSF from Patients with Neuropsychiatric Disorders and Evidence for the Presence of the Activated Form. Klafki, H.W., Lewczuk, P., Kamrowski-Kruck, H., Maler, J.M., Müller, K., Peters, O., Heuser, I., Jessen, F., Popp, J., Frölich, L., Wolf, S., Prinz, B., Luckhaus, C., Schröder, J., Pantel, J., Gertz, H.J., Kölsch, H., Müller, B.W., Esselmann, H., Bibl, M., Kornhuber, J., Wiltfang, J. | Alzheimers Dis. | 2009 | View |
Mechanisms of glucose homeostasis after Roux-en-Y gastric bypass surgery in the obese, insulin-resistant Zucker rat. Meirelles, K., Ahmed, T., Culnan, D.M., Lynch, C.J., Lang, C.H., Cooney, R.N. | Ann Surg. | 2009 | View |
Microbial translocation, the innate cytokine response, and HIV-1 disease progression in Africa. Redd, A.D., Dabitao, D., Bream, J.H., Charvat, B., Laeyendecker, O., Kiwanuka, N., Lutalo, T., Kigozi, G., Tobian, A.A., Gamiel, J., Neal, J.D., Oliver, A.E., Margolick, J.B., Sewankambo, N., Reynolds, S.J., Wawer, M.J., Serwadda, D., Gray, R.H., Quinn, T.C. | Proc Natl Acad Sci USA. | 2009 | View |
Molecular pharmacology of phosphatidylinositol 3-kinase inhibition in human glioma. Guillard, S., Clarke, P.A., Te Poele, R., Mohri, Z., Bjerke, L., Valenti, M., Raynaud, F., Eccles, S.A., Workman, P. | Cell Cycle. | 2009 | View |
Natural History of Markers of Collagen Turnover in Patients With Early Diastolic Dysfunction and Impact of Eplerenone. Mak, G.J., Ledwidge, M.T., Watson, C.J., Phelan, D.M., Dawkins, I.R., Murphy, N.F., Patle, A.K., Baugh, J.A., McDonald, K.M. | J Am Coll Cardiol. | 2009 | View |
Negative Regulators of Insulin Signaling Revealed in a Genome-Wide Functional Screen. Huang, S.A., Hancock, M.K., Pitman, J.L., Orth, A.P., Gekakis, N. | PLoS ONE | 2009 | View |
Novel Tight-Binding Inhibitory Factor-kB Kinase (IKK-2) Inhibitors Demonstrate Target-Specific Anti-Inflammatory Activities in Cellular Assays and following Oral and Local Delivery in an in Vivo Model of Airway Inflammation. Sommers, C.D., Thompson, J.M., Guzova, J.A., Bonar, S.L., Rader, R.K., Mathialagan, S., Venkatraman, N., Holway, V.W., Kahn, L.E., Hu, G., Garner, D.S., Huang, H.C., Chiang, P.C., Schindler, J.F., Hu, Y., Meyer, D.M., Kishore, N.N. | J Pharmacol Exp Ther. | 2009 | View |
Nox4 mediates the expression of plasminogen activator inhibitor-1 via p38 MAPK pathway in cultured human endothelial cells. Jaulmes, A., Sansilvestri-Morel, P., Rolland-Valognes, G., Bernhardt, F., Gaertner, R., Lockhart, B.P., Cordi, A., Wierzbicki, M., Rupin, A., Verbeuren, T.J. | Thromb Res. | 2009 | View |
Optimization and validation of a multiplex, electrochemiluminescence-based detection assay for the quantitation of immunoglobulin g serotype-specific antipneumococcal antibodies in human serum. Marchese, R.D., Puchalski, D., Miller, P., Antonello, J., Hammond, O., Green, T., Rubinstein, L.J., Caulfield, M.J., Sikkema, D. | Clinical and Vaccine Immunology | 2009 | View |
p38 mitogen-activated protein kinase targets the production of proinflammatory endothelial microparticles. Curtis, A.M., Wilkinson, P.F., Gui, M., Gales, T.L, Hu, E., Edelberg, J.M. | J Thromb Haemost. | 2009 | View |
Pharmacokinetic and pharmacodynamic evaluation of the suitability of using fluticasone and an acute rat lung inflammation model to differentiate lung versus systemic efficacy. Chiang, P.C., Hu, Y., Thurston, A., Sommers, C.D., Guzova, J.A., Kahn, L.E., Lai, Y., Blom, J.D. | J Pharm Sci. | 2009 | View |
Physical training after percutaneous coronary intervention in patients with stable angina: effects on working capacity, metabolism, and markers of inflammation. Astengo, M., Dahl, A., Karlsson, T., Mattsson-Hultén, L., Wiklund, O., Wennerblom, B. | European Journal of Cardiovascular Prevention & Rehabilitation. | 2009 | View |
Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestations. Gourh, P., Arnett, F.C., Assassi, S., Tan, F.K., Huang, M., Diekman, L., Mayes, M.D., Reveille, J.D., Agarwal, S.K. | Arthritis Res Ther. | 2009 | View |
Polyanionic Microbicides Modify TLR_mediated Cervicovaginal immune response. Trifonova, R.T., Doncel, G.F., Fichorova, R.N. | Antimicrob Agents Chemother. | 2009 | View |
PPAR-delta agonism activates fatty acid oxidation via PGC-1alpha but does not increase mitochondrial gene expression and function. Kleiner, S., Nguyen-Tran, V., Baré, O., Huang, X., Spiegelman, B., Wu, Z. | J. Biol. Chem. | 2009 | View |
Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase. Winkler, E., Hobson, S., Fukumori, A., Dümpelfeld, B., Luebbers, T., Baumann, K., Haass, C., Hopf, C., Steiner, H. | Biochemistry. | 2009 | View |
Raxibacumab for the Treatment of Inhalational Anthrax. Migone, T.S., Subramanian, G.M., Zhong, J., Healey, L.M., Corey, A., Devalaraja, M., Lo, L., Ullrich, S., Zimmerman, J., Chen, A., Lewis, M., Meister, G., Gillum, K., Sanford, D., Mott, J., Bolmer, S.D. | The New England Journal of Medicine. | 2009 | View |
Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes. Ohya, T., Miaczynska, M., Coskun, U., Lommer, B., Runge, A., Drechsel, D., Kalaidzidis, Y., Zerial, M. | Nature. | 2009 | View |
Reduced cerebrospinal fluid BACE1 activity in multiple sclerosis. Mattsson, N., Axelsson, M., Haghighi, S., Malmeström, C., Wu, G., Anckarsäter, R., Sankaranarayanan, S., Andreasson, U., Fredrikson, S., Gundersen, A., Johnsen, L., Fladby, T., Tarkowski, A., Trysberg, E., Wallin, A., Anckarsäter, H., Lycke, J., Andersen, O., Simon, A.J., Blennow, K., Zetterberg, H. | Mult Scler. | 2009 | View |
Reduced levels of amyloid-beta-binding proteins in cerebrospinal fluid from Alzheimer's disease patients. Hansson, S.F., Andréasson, U., Wall, M., Skoog, I., Andreasen, N., Wallin, A., Zetterberg, H., Blennow, K. | J Alzheimers Dis. | 2009 | View |
Searching immunodominant epitopes prior to epidemic: HLA class II-restricted SARS-CoV spike protein epitopes in unexposed individuals. Yang, J.B., James, E., Roti, M., Huston, L., Gebe, J.A., Kwok, W.W. | Intrnl Immuno. | 2009 | View |
Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice. Wu, X., Ge, H., Lemon, B., Weiszmann, J., Gupte, J., Hawkins, N., Li, X., Tang, J., Lindberg, R., Li, Y. | Proc Natl Acad Sci USA. | 2009 | View |
Serum concentrations of cytokines and lung cancer survival in African Americans and Caucasians. Enewold, L., Mechanic, L.E., Bowman, E.D., Zheng, Y.L., Yu, Z., Trivers, G., Alberg, A.J., Harris, C.C. | Cancer Epidemiol Biomarkers Prev. | 2009 | View |
Serum molecular signatures of weight change during early breast cancer chemotherapy. Keun, H.C., Sidhu, J., Pchejetski, D., Lewis, J.S., Marconell, H., Patterson, M., Bloom, S.R., Amber, V., Coombes, R.C., Stebbing, J. | Clin Cancer Res. | 2009 | View |
Sputum IL-5 Concentration Is Associated with a Sputum Eosinophilia and Attenuated by Corticosteroid Therapy in COPD. Bafadhel, M., Saha, S., Siva, R., McCormick, M., Monteiro, W., Rugman, P., Dodson, P., Pavord, I.D., Newbold, P., Brightling, C.E. | Respiration. | 2009 | View |
Structural details and composition of Trichomonas vaginalis lipophosphoglycan in relevance to the epithelial immune function. Singh, B.N., Hayes, G.R., Lucas, J.J., Sommer, U., Viseux, N., Mirgorodskaya, E., Trifonova, R.T., Sassi, R.R., Costello, C.E., Fichorova, R.N. | Glycoconj J. | 2009 | View |
Systemic inflammation and disease progression in Alzheimer disease. Holmes, C., Cunningham, C., Zotova, E., Woolford, J., Dean, C., Kerr, S., Culliford, D., Perry, V.H. | Neurology. | 2009 | View |
Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease. Di Sabatino, A., Rovedatti, L., Kaur, R., Spencer, J.P., Brown, J.T., Morisset, V.D., Biancheri, P., Leakey, N.A., Wilde, J.I., Scott, L., Corazza, G.R., Lee, K., Sengupta, N., Knowles, C.H., Gunthorpe, M.J., McLean, P.G., MacDonald, T.T., Kruidenier, L. | J Immunol Methods | 2009 | View |
Technology comparisons for anti-therapeutic antibody and neutralizing antibody assays in the context of an anti-TNF pharmacokinetic study. Loyet, K.M., Deng, R., Liang, W.C., Wu, Y., Lowman, H.B., Deforge, L.E. | Journal of Immunological Methods | 2009 | View |
The alpha7 nicotinic acetylcholine receptor on fibroblast-like synoviocytes and in synovial tissue from rheumatoid arthritis patients: A possible role for a key neurotransmitter in synovial inflammation. Maanen, M.A., Stoof, S.P., van der Zanden, E.P., de Jonge, W.J., Janssen, R.A., Fischer, D.F., Vandeghinste, N., Brys, R., Vervoordeldonk, M.J., Tak, P.P. | Arthritis Rheum. | 2009 | View |
The hydrophobic tunnel present in LOX-1 is essential for oxidized Low-density lipoprotein recognition and binding. Francone, O.L., Tu, M., Royer, L.J., Zhu, J., Stevens, K., Oleynek, J.J., Lin, Z., Shelley, L., Sand, T., Luo, Y., Kane, C.D. | J Lipid Res. | 2009 | View |
The impact of Fc engineering on an anti-CD19 antibody: increased Fcgamma receptor affinity enhances B-cell clearing in nonhuman primates. Zalevsky, J., Leung, I.W., Karki, S., Chu, S.Y., Zhukovsky, E.A., Desjarlais, J.R., Carmichael, D.F., Lawrence, C.E. | Blood | 2009 | View |
The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain Lien, L.F., Haqq, A.M., Arlotto, M., Slentz, C.A., Muehlbauer, M.J., McMahon, R.L., Rochon, J., Gallup, D., Bain, J.R., Ilkayeva, O., Wenner, B.R., Stevens, R.D., Millington, D.S., Muoio, D.M., Butler, M.D., Newgard, C.B., Svetkey, L.P. | OMICS. | 2009 | View |
Trans fat feeding results in higher serum alanine aminotransferase and increased insulin resistance compared with a standard murine high-fat diet. Koppe, S.W., Elias, M., Moseley, R.H., Green, R.M. | Am J Physiol Gastrointest Liver Physiol. | 2009 | View |
TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines. Kuai, J., Gregory, B., Hill, A., Pittman, D.D., Feldman, J.L., Brown, T., Carito, B., O'Toole, M., Ramsey, R., Adolfsson, O., Shields, K.M., Dower, K., Hall, J.P., Kurdi, Y., Beech, J.T., Nanchahal, J., Feldmann, M., Foxwell, B.M., Brennan, F.M., Winkler, D.G., Lin, L.L. | Rheumatology (Oxford). | 2009 | View |
Tumour necrosis factor a mediates transient receptor potential vanilloid 1-dependent bilateral thermal hyperalgesia with distinct peripheral roles of interleukin-1ß, protein kinase C and cyclooxygenase-2 signaling. Russell, F.A., Fernandesa, E.S., Couradeb J.P., Keeblea, J.E., Brain, S.D. | Pain. | 2009 | View |