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A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease.
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A Phase II Clinical Trial of Sorafenib in Androgen-Independent Prostate Cancer.
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A Protective Role for the Human SMG-1 Kinase against Tumor Necrosis Factor-alpha induced Apoptosis
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Acute-Phase Serum Amyloid A as a Marker of Insulin Resistance in Mice.
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Addiction to Elevated Insulin-like Growth Factor I Receptor and Initial Modulation of the AKT Pathway Define the Responsiveness of Rhabdomyosarcoma to the Targeting Antibody.
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Agents associated with lung inflammation induce similar responses in NCI-H292 lung epithelial cells.
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Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs.
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Antibody based Proteomics to Study Cellular Signaling Networks.
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Applicability of Biomarkers Is Far-Reaching.
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Asparagine synthetase is a predictive biomarker of L-asparaginase activity in ovarian cancer cell lines.
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Assessment of Unwanted Immunogenicity (Book chapter)
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Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: a multicenter study.
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Biomarker Sample Collection and Handling in the Clinical Setting to Support Early-Phase Drug in Biomarker Methods in Drug Discovery and Development (Book Chapter)
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Biomarkers of apoptosis.
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Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes.
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Cardiac troponin is the most effective translational safety biomarker for myocardial injury in cardiotoxicity.
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Challenges in translating plasma proteomics from bench to bedside: update from the NHLBI Clinical Proteomics Programs.
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Chronic Mouse Model of TMA-Induced Contact Hypersensitivity.
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Coligation of the Hepatitis C Virus Receptor CD81 with CD28 Primes Naive T Lymphocytes to Acquire Type 2 Effector Function.
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Combination Targeted Therapy With Sorafenib and Bevacizumab Results in Enhanced Toxicity and Antitumor Activity.
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Concurrent decrease in IL-10 with development of immune-related adverse events in a patient treated with anti-CTLA-4 therapy.
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Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-{kappa}B pathways in subtypes of diffuse large B-cell lymphoma.
Lam, L.T., Wright, G., Davis, R.E., Lenz, G., Farinha, P., Dang, L., Chan, J.W., Rosenwald, A., Gascoyne, R.D., Staudt, L.M. | Blood | 2008 | View |
CSF amyloid- 1-38 and 1-42 in FTD and AD: Biomarker performance critically depends on the detergent accessible fraction.
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Current In Vitro Kinase Assay Technologies: The Quest for a Universal Format.
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Cytokine Multiplex Analysis in Inflammation and Cancer.
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Detection of ricin in food using electrochemiluminescence-based technology.
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Development, Validation, and Clinical Implementation of an Assay to Measure Total Antibody Response to Naglazyme(R) (Galsulfase).
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Discovery of Highly Selective and Potent p38 Inhibitors Based on a Phthalazine Scaffold.
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Dynamics of Ab Turnover and Deposition in Different APP Transgenic Mouse Models Following Gamma-Secretase Inhibition.
Abramowski, D., Wiederhold, K. Furrer, U., Jaton, A., Neuenschwander, A., Runser, M., Danner, S., Reichwald, J., Ammaturo, D., Staab, D., Stoeckli, M., Rueeger, H., Neumann, U., Staufenbiel, M. | Pharmacol Exp Ther. | 2008 | View |
Effect of phenserine treatment on brain functional activity and amyloid in Alzheimer's disease.
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Effects of palifermin on antitumor activity of chemotherapeutic and biological agents in human head and neck and colorectal carcinoma xenograft models.
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Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting.
Rajendran, L., Schneider, A., Schlechtingen, G., Weidlich, S., Ries, J., Braxmeier, T., Schwille, P., Schulz, J.B., Schroeder, C., Simons, M., Jennings, G., Knölker, H.J., Simons, K. | Science. | 2008 | View |
Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category.
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Electrogenerated Chemiluminescence and Its Biorelated Applications
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Elevated Cerebrospinal Fluid BACE1 Activity in Incipient Alzheimer Disease.
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ELISA and Multiplex Technologies for Cytokine Measurement in Inflammation and Aging Research.
Leng, S.X., McElhaney, J.E., Walston J.D., Xie D.X., Fedarko N.S., Kuchel, G.A. | J Gerontol A Biol Sci Med Sci. | 2008 | View |
Endogenous and synthetic agonists of GPR119 differ in signaling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells.
Ning, Y, O'Neill, K, Lan, H, Pang, L, Shan, L.X., Hawes B.E., Hedrick, J.A. | Br J Pharmacol. | 2008 | View |
Fragment-Based Design of Small Molecule X-Linked Inhibitor of Apoptosis Protein Inhibitors.
Huang, J.W., Zhang, Z., Wu, B., Cellitti, J.F., Zhang, X., Dahl, R., Shiau, C.W., Welsh, K., Emdadi, A., Stebbins, J.L., Reed, J.C., Pellecchia, M. | J Med Chem. | 2008 | View |
Healthy human subjects have CD4+ T cells directed against H5N1 influenza virus.
Roti, M., Yang, J., Berger, D., Huston, L., James, E.A., Kwok, W.W. | J Immunol Methods | 2008 | View |
High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs.
Rottenberg, S., Jaspers, J.E., Kersbergen, A., van der Burg, E., Nygren, A.O., Zander, S.A., Derksen, P.W., de Bruin, M., Zevenhoven, J., Lau, A., Boulter, R., Cranston, A., O'Connor, M.J., Martin, N.M., Borst, P., Jonkers, J. | PNAS | 2008 | View |
HIV infection-associated immune activation occurs by two distinct pathways that differentially affect CD4 and CD8 T cells.
Catalfamo, M., Di Mascio, M., Hu, Z., Srinivasula, S., Thaker, V., Adelsberger, J., Rupert, A., Baseler, M., Tagaya, Y., Roby, G., Rehm, C., Follmann, D., Lane, H.C. | PNAS. | 2008 | View |
Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high-throughput electrochemiluminescent screen.
Sasiela, C.A., Stewart, D.H., Kitagaki, J., Safiran, Y.J., Yang, Y., Weissman, A.M., Oberoi, P., Davydov, I.V., Goncharova, E., Beutler, J.A., McMahon, J.B., O'Keefe, B.R. | J Biomol Screen. | 2008 | View |
IL-4 protein expression and basal activation of Erk in vivo in follicular lymphoma.
Calvo, K.R., Dabir, B., Kovach, A., Devor, C., Bandle, R., Bond, A., Shih, J.H., Jaffe, E.S. | Blood | 2008 | View |
Immuno's Logical - Drug developers turn to the new and established immunoassay platforms to measure and identify protein biomarkers.
Netterwald, J. | Drug Disc Devel. | 2008 | View |
Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels.
Riddell, D.R., Zhou, H., Atchison, K., Warwick, H.K., Atkinson, P.J., Jefferson, J., Xu, L., Aschmies, S., Kirksey, Y., Hu, Y., Wagner, E., Parratt, A., Xu, J., Li, Z., Zaleska, M.M., Jacobsen, J.S., Pangalos, M.N., Reinhart, P.H. | J Neurosci. | 2008 | View |
Impact of cholesterol level upon APP and BACE proximity and APP cleavage.
von Arnim, C.A., von Einem, B., Weber, P., Wagner, M., Schwanzar, D., Spoelgen, R., Strauss, W.L., Schneckenburger, H. | Biochem Biophys Res Commun. | 2008 | View |
Impaired dendritic cell maturation and cytokine production in patients with chronic mucocutanous candidiasis with or without APECED.
Ryan, K.R., Hong, M., Arkwright, P.D., Gennery, A.R., Costigan, C., Dominguez, M., Denning, D., McConnell, V., Cant, A.J., Abinun, M., Spickett, G.P., Lilic, D. | Clin Exp Immunol. | 2008 | View |
Influenza A virus inhibits alveolar fluid clearance in BALB/c mice.
Wolk, K.E., Lazarowski, E.R., Traylor, Z.P., Yu, E.N., Jewell, N.A., Durbin, R.K., Durbin, J.E., Davis, I.C. | Am J Respir Crit Care Med. | 2008 | View |
Inhibiting Hdm2 and Ubiquitin-Activating Enzyme: Targeting the Ubiquitin Conjugating System in Cancer.
Weissman, A.M., Yang, Y., Kitagaki, J., Sasiela, C.A., Beutler, J.A., O'Keefe, B.R. | The Ubiquitin System in Health and Disease. Springer Berlin Heidelberg. | 2008 | View |
Innate Immune Responses to TREM-1 Activation: Overlap, Divergence, and Positive and Negative Cross-Talk with Bacterial Lipopolysaccharide.
Dower, K., Ellis, D.K., Saraf, K, Jelinsky, S.A., Lin, L.L. | J Immunol Methods | 2008 | View |
Kinetic characterization and identification of a novel inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 using a time-resolved fluorescence resonance energy transfer-based assay technology.
Dao, J.H., Kurzeja, R.J., Morachis, J.M., Veith, H., Lewis, J., Yu, V., Tegley, C.M., Tagari, P. | Anal Biochem. | 2008 | View |
Lack of FFAR1/GPR40 Does Not Protect Mice From High-Fat Diet-Induced Metabolic Disease.
Lan, H., Hoos, L.M., Liu, L., Tetzloff, G., Hu, W., Abbondanzo, S.J., Vassileva, G., Gustafson, E.L., Hedrick, J.A., Davis, H.R. | Diabetes | 2008 | View |
Lactoferrin acts as an alarmin to promote the recruitment and activation of APCs and antigen-specific immune responses.
de la Rosa, G., Yang, D., Tewary, P., Varadhachary, A., Oppenheim, J.J. | J Immunol Methods | 2008 | View |
Liver TAG transiently decreases while PL n-3 and n-6 fatty acids are persistently elevated in insulin resistant mice.
Scheja, L., Toedter, K., Mohr, R., Niederfellner, G., Michael, M.D., Meissner, A., Schoettler, A., Pospisil, H., Beisiegel, U., Heeren, J. | Lipids. | 2008 | View |
mall-Molecule Inhibitors of PDK1.
Peifer, C., Alessi, D.R. | ChemMedChem. | 2008 | View |
MCP-1-deficient mice show reduced neuroinflammatory responses and increased peripheral inflammatory responses to peripheral endotoxin insult.
Thompson, W.L., Karpus W.J., Van Eldik, L.J. | J Neuroinflammation. | 2008 | View |
Measurement of bovine somatotropin (bST) and insulin-like growth factor-1 (IGF-1) in bovine milk using an electrochemiluminescent assay.
McGrath, M.F., Bogosian, G., Fabellar, A.C., Staub, R.L., Vicini, J.L., Widger, L.A. | J Agric Food Chem. | 2008 | View |
Measuring the tyrosine kinase activity: a review of biochemical and cellular assay technologies.
Jia, Y., Gu, X., Brinker, A., Warmuth, M. | Expert Opinion on Drug Discovery. | 2008 | View |
Modulation of LPS-induced pulmonary neutrophil infiltration and cytokine production by the selective PPARbeta/delta ligand GW0742.
Haskova, Z., Hoang, B., Luo, G., Morgan, L.A., Billin, A.N., Barone, F.C., Shearer, B.G., Barton, M.E., Kilgore, K.S. | Inflamm Res. | 2008 | View |
Mutual antagonistic relationship between prostaglandin E(2) and IFN-gamma: Implications for rheumatoid arthritis.
Mathieu, M.C., Lord-Dufour, S., Bernier, V., Boie, Y., Burch, J.D., Clark, P., Denis, D., Han, Y., Mortimer, J.R., Therien, A.G. | Eur J Immunol. | 2008 | View |
Neurochemical dementia diagnostics: State of the art and research perspectives.
Lewczuk P, Wiltfang J. | Proteomics | 2008 | View |
New technologies around biomarkers and their interplay with drug development.
Dieterle, F., Marrer, E. | Anal Bioanal Chem. | 2008 | View |
New technologies for diagnosing pediatric tumors.
Wei, J.S., Badgett, T.C., Khan, J. | Expert Opin Med Diagn. | 2008 | View |
Novel technologies for the discovery and quantitation of biomarkers of toxicity.
Collings, F.B., Vaidya, V.S. | Toxicology. | 2008 | View |
NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis.
Eccles, S.A., Massey, A., Raynaud, F.I., Sharp, S.Y., Box, G., Valenti, M., Patterson, L., de Haven Brandon, A., Gowan, S., Boxall, F., Aherne, W., Rowlands, M., Hayes, A., Martins, V., Urban, F., Boxall, K., Prodromou, C., Pearl, L., James, K., Matthews, T.P., Cheung, K.M., Kalusa, A., Jones, K., McDonald, E., Barril, X., Brough, P.A., Cansfield, J.E., Dymock, B., Drysdale, M.J., Finch, H., Howes, R., Hubbard, R.E., Surgenor, A., Webb, P., Wood, M., Wright, L., Workman, P. | Cancer Res. | 2008 | View |
Omega-3 fatty acids effect on wound healing.
McDaniel, J.C., Belury, M., Ahijevych, K., Blakely, W. | Wound Repair Regen. | 2008 | View |
Peripheral elevation of IGF-1 fails to alter Ab clearance in multiple in vivo models.
Lanz, TA., Salatto, C.T., Semproni, AR., Marconi, M., Brown, TM., Richter, KE., Schmidt, K., Nelson, FR., Schachter, JB., | Biochemical Pharmacology | 2008 | View |
Pharmacological properties of SD-282 - an alpha-isoform selective inhibitor for p38 MAP kinase.
Koppelman, B., Webb, H.K., Medicherla, S., Almirez, R., Feng, Y., Chavez, J.C., Mao, C.P., Nguyen, A., Liu, Y.W., Kapoun, A.M., Muiru, G., Huang, Y.A., Dugar, S., Mavunkel, B.J., Lim, D.W., Chakravarty, S., Luedtke, G., Protter, A.A., Higgins, L.S. | Pharmacology. | 2008 | View |
Pharmacological characterization of a small-molecule inhibitor of c-Jun kinase.
Cho, H.K., Black, S.C., Looper, D., Shi, M., Kelly-Sullivan, D., Timofeevski, S., Siegel, K., Yu, X.H., McDonnell, S.R., Chen, P., Yie, J., Ogilvie, K.M., Fraser, J., Briscoe, C.P. | Am J Physiol Endocrinol Metab. | 2008 | View |
Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets.
Waddleton, D., Wu, W., Feng, Y., Thompson, C., Wu, M., Zhou, Y.P., Howard, A., Thornberry, N., Li, J., Mancini, J.A. | Biochemical Pharmacology | 2008 | View |
Place cell firing correlates with memory deficits and amyloid plaque burden in Tg2576 Alzheimer mouse model.
Cacucci ,F., Yi M., Wills, T.J., Chapman, P., O'Keefe, J. | PNAS | 2008 | View |
Plasma PCSK9 Concentrations Correlate with LDL and Total Cholesterol in Diabetic Patients and Are Decreased by Fenofibrate Treatment.
Lambert, G., Ancellin, N., Charlton, F., Comas, D., Pilot, J., Keech, A., Patel, S., Sullivan, D.R., Cohn, J.S., Rye, K.A., Barter, P.J. | Clin Chem. | 2008 | View |
Practical approaches to proteomic biomarkers within prostate cancer radiotherapy trials.
Christensen, E., Evans, K.R., Menard, C., Pintilie, M., Bristow, R.G. | Cancer Metastasis Rev. | 2008 | View |
Protein kinase B/Akt activity is involved in renal TGF-{beta}1-driven epithelial-mesenchymal transition in vitro and in vivo.
Kattla, J.J., Carew, R.M., Heljic, M., Godson, C., Brazil, D.P. | Am J Physiol Renal Physiol. | 2008 | View |
Protein Microarray Technologies for Detection and Identification of Bacterial and Protein Analytes in Principles of Bacterial Detection: Biosensors, Recognition Receptors and Microsystems.(Book Chapter)
Wingren, C., Borrebaeck, C.A.K. | ed. Zourob, M. | 2008 | View |
Reactivation of human herpesvirus-6 in natalizumab treated multiple sclerosis patients.
Yao, K., Gagnon, S., Akhyani, N., Williams, E., Fotheringham, J., Frohman, E., Stuve, O., Monson, N., Racke, M.K., Jacobson, S. | PLoS ONE | 2008 | View |
Regulator of G-protein signaling 10 promotes dopaminergic neuron survival via regulation of the microglial inflammatory response.
Lee, J.K., McCoy M.K, Harms, A.S, Ruhn, K.A., Gold S.J., Tansey M.G. | J Neurosci. | 2008 | View |
RU486 did not exacerbate cytokine release in mice challenged with LPS nor in db/db mice.
Yang, B., Trump, R.P., Shen, Y., McNulty, J.A., Clifton, L.G., Stimpson, S.A., Lin, P., Pahel, G.L. | BMC Pharmacology. | 2008 | View |
Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial.
Lannfelt, L., Blennow, K., Zetterberg, H., Batsman, S., Ames, D., Harrison, J., Masters, C.L., Targum, S., Bush, A.I., Murdoch, R., Wilson, J., Ritchie, C.W., PBT2-201-EURO study group. | Lancet Neurol. | 2008 | View |
Simultaneous Detection of Eight Analytes in Human Serum by Two Commercially Available Platforms for Multiplex Cytokine Analysis.
Toedter, G., Hayden, K., Wagner, C., Brodmerkel, C. | Clin Vaccine Immunol. | 2008 | View |
Structural and functional characterization of disulfide isoforms of the human IGG2 subclass.
Dillon, T.M., Ricci, M.S., Vezina, C., Flynn, G.C. Liu, Y. D., Rehder, D.S., Plant, M., Henkle, B., Li, Y., Deechongkit, S., Varnum, B., Wypych, J., Balland, A., Bondarenko P. V. | J Biol Chem. | 2008 | View |
Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury.
Lloyd, E., Somera-Molina, K., Van Eldik, L.J., Watterson, D.M., Wainwright, M.S. | J Neuroinflammation. | 2008 | View |
Survey of retail milk composition as affected by label claims regarding farm-management practices.
Vicini, J, Etherton, T., Kris-Etherton, P., Ballam, J., Denham, S., Staub, R., Goldstein, D., Cady, R., McGrath, M., Lucy, M. | J Am Diet Assoc. | 2008 | View |
The anthrax vaccine adsorbed vaccine generates protective antigen (PA)-Specific CD4+ T cells with a phenotype distinct from that of naive PA T cells.
Kwok, W.W., Yang, J., James, E., Bui, J., Huston, L., Wiesen, A.R., Roti, M. | Infect Immun. | 2008 | View |
The antileukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells.
Luqman, M., Klabunde, S., Lin, K., Georgakis, G.V., Cherukuri, A., Holash, J., Goldbeck, C., Xu, X., Kadel, E.E. 3rd, Lee, S.H., Aukerman, S.L., Jallal, B., Aziz, N., Weng, W.K., Wierda, W., O'Brien, S., Younes, A. | Blood | 2008 | View |
The identification of a small molecule inhibitor that specifically reduces T cell-mediated adaptive but not LPS-mediated innate immunity by T cell membrane-monocyte contact bioassay.
Li, Y.Y., Bao, M., Meurer, J., Skuballa, W., Bauman, J.G., Doecke, W.D., Zollner, T.M. | Immunol Lett. | 2008 | View |
The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer.
Folkes, A.J., Ahmadi, K., Alderton, W.K., Alix, S., Baker, S.J., Box, G., Chuckowree, I.S., Clarke, P.A., Depledge, P., Eccles, S.A., Friedman, L.S., Hayes, A., Hancox, T.C., Kugendradas, A., Lensun, L., Moore, P., Olivero, A.G., Pang, J., Patel, S., Pergl-Wilson, G.H., Raynaud, F.I., Robson, A., Saghir, N., Salphati, L., Sohal, S., Ultsch, M.H., Valenti, M., Wallweber, H.J., Wan, N.C., Wiesmann, C., Workman, P., Zhyvoloup, A., Zvelebil, M.J., Shuttleworth, S.J. | J Med Chem. | 2008 | View |
The p50 subunit of NF-kappaB is critical for in vivo clearance of the noninvasive enteric pathogen Citrobacter rodentium.
Dennis, A., Kudo, T., Kruidenier, L., Girard, F., Crepin, V.F., MacDonald, T.T., Frankel, G., Wiles, S. | Infect Immun. | 2008 | View |
The Stem Cell Marker CD133 (Prominin-1) Is Expressed in Various Human Glandular Epithelia.
Karbanova, J., Missol-Kolka, E., Fonseca, A.V., Lorra, C., Janich, P., Hollerova, H., Jaszai, J., Ehrmann, J., Kolar, Z., Liebers, C., Arl, S., Subrtova, D., Freund, D., Mokry, J., Huttner, W.B., Corbeil, D. | J Hist Cytochem. | 2008 | View |
The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection.
Tran, T.A., McCoy, M.K., Sporn, M.B., Tansey, M.G. | J Neuroinflammation. | 2008 | View |
TLR7 Agonist 852A Inhibition of Tumor Cell Proliferation Is Dependent on Plasmacytoid Dendritic Cells and Type I IFN.
Inglefield, J.R., Dumitru, C.D., Alkan, S.S., Gibson, S.J., Lipson, K.E., Tomai, M.A., Larson, C.J., Vasilakos, J.P. | J Interferon Cytokine Res. | 2008 | View |
Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity.
Fitzgerald, P., Cassidy Eugene, M., Clarke, G., Scully, P., Barry, S., Quigley Eamonn, M.M., Shanahan, F., Cryan, J., Dinan, T. G. | Neurogastroenterol Motil. | 2008 | View |
Tumor necrosis factor-alpha regulates inflammatory and mesenchymal responses via mitogen-activated protein kinase kinase, p38, and nuclear factor kappaB in human endometriotic epithelial cells.
Grund, E.M., Kagan, D., Tran, C.A., Zeitvogel, A., Starzinski-Powitz, A., Nataraja, S., Palmer, S.S. | Mol Pharmacol. | 2008 | View |