IL-23

Interleukin-23 (IL-23) is a heterodimeric cytokine that is structurally and functionally related to IL-12. Both share the 40 kDa (p40) subunit of IL-12, and this forms a disulfide link with a 19 kDa (p19) subunit to make the active IL-23 molecule. IL-23 is produced by activated macrophages and dendritic cells in response to certain bacterial and viral pathogens and may play a key role in sustaining inflammatory responses that link innate and adaptive immunity. The main role of IL-23 involves the differentiation of TH17 cells, a novel subset of CD4+ memory T cells, and their stimulation to produce the cytokine, IL-17. Elevated levels of IL-23 and IL-17 have been consistently observed in autoimmune diseases such as rheumatoid arthritis, inflammatory bowel disease, and diabetes. Chronic over-expression of IL-23 may also play a role in angiogenesis and increased tumor growth. IL-23 is a key player in sustaining cellular immunity by promoting the survival and effector cytokine production of TH1 memory cells.

 

IL-23 Singleplex Products

Our IL-23 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of IL-23. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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IL-23 Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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Related Custom Assays

The following related assays are not in our catalog but may be available as custom orders. Custom orders are typically shipped in 3 to 6 weeks. You may request pricing and availability for the assays below using our Custom Assay Quote Request form.

  • IL-23 - Human
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