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Substitution of the Bordetella pertussis lipid A phosphate groups with glucosamine is required for robust NF-kappaB activation and release of proinflammatory cytokines in cells expressing human but not murine Toll-like receptor 4-MD-2-CD14.
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Systems parasitology: effects of Fasciola hepatica on the neurochemical profile in the rat brain.
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TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action.
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The 4q12 Amplicon in Malignant Peripheral Nerve Sheath Tumors: Consequences on Gene Expression and Implications for Sunitinib Treatment.
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The application of target information and preclinical pharmacokinetic/pharmacodynamic modeling in predicting clinical doses of a Dickkopf-1 antibody for osteoporosis.
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The Effect of Leflunomide on Cycling and Activation of T-Cells in HIV-1-Infected Participants.
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The importance of characterization of FITC-labeled antibodies used in tissue cross-reactivity studies.
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The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing.
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The Metabolic Phenotype of Prader-Willi Syndrome (PWS) in Childhood: Heightened Insulin Sensitivity Relative to Body Mass Index.
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The relationship between neonatal blood protein profiles and placenta histologic characteristics in extremely low gestation age newborns.
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The role of low-density receptor-related protein 1 (LRP1) as a competitive substrate of the amyloid precursor protein (APP) for BACE1.
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The role of the CCL2/CCR2 axis in mouse mast cell migration in vitro and in vivo.
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Traditional risk factors and D-dimer predict incident cardiovascular disease events in chronic HIV infection.
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Transcriptional responses in the adaptation to ischaemia-reperfusion injury: a study of the effect of ischaemic preconditioning in total knee arthroplasty patients.
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12/15-Lipoxygenase Is Required for the Early Onset of High Fat Diet-Induced Adipose Tissue Inflammation and Insulin Resistance in Mice.
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A Randomized, Placebo-Controlled Study of the Effects of the p38 MAPK Inhibitor SB-681323 on Blood Biomarkers of Inflammation in COPD Patients.
Singh, D., Smyth, L., Borrill, Z., Sweeney, L., Tal-Singer, R. | J Clin Pharmacol. | 2009 | View |
AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).
Zarrinkar, P.P., Gunawardane, R.N., Cramer, M.D., Gardner, M.F., Brigham, D., Belli, B., Karaman, M.W., Pratz, K.W., Pallares, G., Chao, Q., Sprankle, K.G., Patel, H.K., Levis, M., Armstrong, R.C., James, J., Bhagwat, S.S. | Blood | 2009 | View |
Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin resistant mouse models-Association with liver and adipose tissue effects.
Xu, J., Stanislaus, S., Chinookoswong, N., Lau, Y.Y., Hager, T., Patel, J., Ge, H., Weiszmann, J., Lu, S.C., Graham, M., Busby, J., Hecht, R., Li, Y.S., Li, Y., Lindberg, R.A., Véniant, M.M. | Am J Physiol Endocrinol Metab. | 2009 | View |
Alzheimer Disease A{beta} Production in the Absence of S-Palmitoylation-dependent Targeting of BACE1 to Lipid Rafts.
Vetrivel, K.S., Meckler, X., Chen, Y., Nguyen, P.D., Seidah, N.G., Vassar, R., Wong, P.C., Fukata, M., Kounnas, M.Z. Thinakaran, G. | J Biol Chem. | 2009 | View |
AMG 479, a fully human anti-insulin-like growth factor receptor type I monoclonal antibody, inhibits the growth and survival of pancreatic carcinoma cells.
Beltran, P.J., Mitchell, P., Chung, Y.A., Cajulis, E., Lu, J., Belmontes, B., Ho, J., Tsai, M.M., Zhu, M., Vonderfecht, S., Baserga, R., Kendall, R., Radinsky, R., Calzone, F.J. | Mol Cancer Ther. | 2009 | View |
Amphipathic DNA polymers exhibit antiviral activity against systemic murine Cytomegalovirus infection.
Cardin, R.D., Bravo, F.J., Sewell, A.P., Cummins, J., Flamand, L., Juteau, J.M., Bernstein, D.I., Vaillant, A. | Virol J. | 2009 | View |
Amyloid and tau cerebrospinal fluid biomarkers in HIV infection.
Gisslén, M., Krut, J., Andreasson, U., Blennow, K., Cinque, P., Brew, B.J., Spudich, S., Hagberg, L., Rosengren, L., Price, R.W., Zetterberg, H. | BMC Neurol. | 2009 | View |
An electrochemiluminescent aptamer switch for a high-throughput assay of an RNA editing reaction.
Liang, S., Connell, G.J. | RNA. | 2009 | View |
An in vitro perfusion system to examine the responses of endothelial cells to simulated flow and inflammatory stimulation.
Cockcroft, N.Y., Oke, O., Cunningham, F., Bishop, E., Fearon, I.M., Zantl, R., Gaca, M.D. | Altern Lab Anim. | 2009 | View |
An investigation into the potential use of serum Hsp70 as a novel tumour biomarker for Hsp90 inhibitors.
Dakappagari, N., Neely, L., Tangri, S., Lundgren, K., Hipolito, L., Estrellado, A., Burrows, F., Zhang, H. | Biomarkers. | 2009 | View |
Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice.
Kumar, K.G., Sutton, G.M., Dong, J.Z., Roubert, P., Plas, P., Halem, H.A., Culler, M.D., Yang, H., Dixit, V.D., Butler, A.A. | Peptides. | 2009 | View |
Antibody protection against botulinum neurotoxin intoxication in mice.
Cheng, L.W., Stanker, L.H., Henderson, T.D. 2nd, Lou, J., Marks, J.D. | Infect Immun. | 2009 | View |
Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma.
Ma, Q., Cavallin, L.E., Yan, B., Zhu, S., Duran, E.M., Wang, H., Hale, L.P., Dong, C., Cesarman, E., Mesri, E.A., Goldschmidt-Clermont, P.J. | Proc Natl Acad Sci USA. | 2009 | View |
Application of deadenylase electrochemiluminescence assay for ricin to foods in a plate format.
Cho, C.Y., Keener, W.K., Garber, E.A. | J Food Prot. | 2009 | View |
Application of multi-factorial design of experiments to successfully optimize immunoassays for robust measurements of therapeutic proteins.
Ray, C.A., Patel, V., Shih, J., Macaraeg, C., Wu, Y., Thway, T., Ma, M., Lee, J.W., Desilva, B. | Journal of Pharmaceutical and Biomedical Analysis | 2009 | View |
Atheroprotective Effects of Alum Are Associated With Capture of Oxidized LDL Antigens and Activation of Regulatory T Cells.
Wigren, M., Bengtsson, D., Dunér, P., Olofsson, K., Björkbacka, H., Bengtsson, E., Fredrikson, G.N., Nilsson, J. | Circ Res. | 2009 | View |