Veterinary and toxicological applications for the detection of cardiac injury using cardiac troponin.

Serra M, Papakonstantinou S, Adamcova M, O'Brien PJ.
Journal   Vet J. 2010 Jul;185(1):50-7.
Species  
Analytes Measured   Troponin I cardiac , Troponin T cardiac , FABP3
Matrix Tested   Plasma, serum
Year   2010
Volume   185
Page Numbers   50-57
Application   Toxicology
Abstract
The use of cardiac troponin (cTn), the 'gold-standard' biomarker of myocardial injury in humans, is growing in veterinary medicine and in animal safety studies, although there are differences in its application in animals. In this study six new assays for the marker were assessed in 619 animals of six different species (dog, cat, horse, cattle, rat and rabbit), in clinical and drug-safety studies. Healthy animals and clinical cases without cardiac disease served as controls. Several of the tested assays had poor analytic or diagnostic sensitivity and only one test was effective in all species and in all models of cardiac injury. This assay had the highest sensitivity and widest dynamic range, and identified cardiac injury due to anaemia, pancreatitis, uncontrolled Addison's and Cushing's disease, old age, renal disease, severe colic, lymphoma and neoplasia. Detection of the cTnI and cTnT forms correlated with loss of cardiac function in toxicity studies in rodents and rabbit. Increased serum cTnI was not found to correlate with disease aetiology or pathogenesis, but was effective in detecting, monitoring and quantifying ongoing cardiac injury. Cardiac injury, as demonstrated by elevated cTnI in blood, appears to be a common sequel to a wide variety of both primarily cardiac disease and of other diseases that do not primarily involve the cardiovascular system.

View Publications

Related Products

R-PLEX Human Troponin T Cardiac Antibody Set
Troponin T (cardiac) | Human
Singleplex
R-PLEX Human FABP3/H-FABP Antibody Set
FABP3/H-FABP | Human
Singleplex
Human FABP3 Kit
FABP3/H-FABP | Human
Singleplex
Muscle Injury Panel 3 Mouse Kit
cTroponin I, FABP3/H-FABP, Myl3/CMLC1, Troponin I (fast-twitch) | Mouse
Multiplex
Muscle Injury Panel 1 Rat Kit
cTroponin I, FABP3/H-FABP, Myl3/CMLC1, Troponin I (fast-twitch), Troponin T (cardiac) | Rat
Multiplex
Rat Cardiac Troponin ITC Complex Kit
cTroponin I, Troponin ITC Complex | Rat
Singleplex
Cardiac Injury Panel 2 Rat Kit
cTroponin I, FABP3/H-FABP, Troponin T (cardiac) | Rat
Multiplex
Cardiac Injury Panel 3 Rat Kit
cTroponin I, FABP3/H-FABP, Myl3/CMLC1, Troponin T (cardiac) | Rat
Multiplex
Browse Our Products

By Analytes
By Applications
Search
Customer Service/Orders


Scientific/Technical Support


Instrument Support


Company Headquarters