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Dectin-2 sensing of house dust mite is critical for the initiation of airway inflammation.
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Deletion of the gene encoding calcitonin and CGRPα does not affect the outcome of severe infection in mice.
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Development of novel in vivo chemical probes to address CNS protein kinase involvement in synaptic dysfunction.
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Diacylglycerol Acyltransferase-1 (DGAT1) inhibition perturbs postprandial gut hormone release.
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Differential Serum Levels of Eosinophilic Eotaxins in Primary Sclerosing Cholangitis, Primary Biliary Cirrhosis, and Autoimmune Hepatitis.
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Doxycycline reduces cardiac Matrix Metalloproteinase-2 activity but does not ameliorate myocardial dysfunction during reperfusion in coronary artery bypass patients undergoing cardiopulmonary bypass.
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Dystrophin-deficient cardiomyocytes derived from human urine: New biologic reagents for drug discovery.
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Early prediction of polymyxin-induced nephrotoxicity with next generation urinary kidney injury biomarkers.
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Effect of Linezolid on clinical severity and pulmonary cytokines in a murine model of Influenza A and Staphylococcus aureus coinfection.
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Effect of orally administered L. fermentum NCIMB 5221 on markers of metabolic syndrome: an in vivo analysis using ZDF rats
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Effects of a FLAP inhibitor, GSK2190915, in asthmatics with high sputum neutrophils.
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Effects of Lactobacillus helveticus on murine behavior are dependent on diet and genotype and correlate with alterations in the gut microbiome.
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Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency.
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Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis.
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Efflux of monoclonal antibodies from rat brain by neonatal Fc receptor, FcRn.
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Elevated insulin-like growth factor binding protein-1 (IGFBP-1) in men with metastatic prostate cancer starting androgen deprivation therapy (ADT) is associated with shorter time to castration resistance and overall survival.
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Elevated sputum Interleukin-5 and submucosal eosinophilia in obese severe asthmatics.
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Endothelial injury markers before and after nasal continuous positive airway pressure treatment for obstructive sleep apnoea hypopnoea syndrome.
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Endurance training in prostate cancer patients treated with androgen deprivation therapy.
Hvid T, Winding K, Rinnov A, Dejgaard T, Thomsen C, Iversen P, Brasso K, Mikines KJ, van Hall G, Lindegaard B, Solomon TP, Pedersen BK. | Endocr Relat Cancer | 2013 | View |
Engagement of Two Distinct Binding Domains on CCL17 Is Required for Signaling through CCR4 and Establishment of Localized Inflammatory Conditions in the Lung.
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Enhanced proteolytic clearance of plasma Aβ by peripherally administered neprilysin does not result in reduced levels of brain Aβ in mice.
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Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo.
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Epigenetic induction of EGR-1 expression by the amyloid precursor protein during exposure to novelty.
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Evaluation of immunogenicity and protective efficacy of orally delivered Shigella type III secretion system proteins IpaB and IpaD.
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Evaluation of the Relative Performance of Twelve Urinary Biomarkers for Renal Safety across Twenty Two Rat Sensitivity and Specificity Studies.
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Evaluation of the stability, bioavailability, and hypersensitivity of the omega-3 derived anti-leukemic prostaglandin: δ(12)-prostaglandin j3.
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Experimental pain and opioid analgesia in volunteers at high risk for obstructive sleep apnea
Doufas AG, Tian L, Padrez KA, Suwanprathes P, Cardell JA, Maecker HT, Panousis P. | PLoS One | 2013 | View |
False-positive immunogenicity responses are caused by CD20+ B cell membrane fragments in an anti-ofatumumab antibody bridging assay.
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FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/β-Klotho bispecific protein.
Smith R, Duguay A, Bakker A, Li P, Weiszmann J, Thomas MR, Alba BM, Wu X, Gupte J, Yang L, Stevens J, Hamburger A, Smith S, Chen J, Komorowski R, Moore KW, Véniant MM, Li Y. | PLoS One | 2013 | View |
Fibroblast growth factor 21 mediates specific glucagon actions.
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FRET-based calcium imaging: a tool for high-throughput/content phenotypic drug screening in Alzheimer disease.
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Functional Consequences of the Macrophage Stimulating Protein 689C Inflammatory Bowel Disease Risk Allele.
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Functional testing of an inhalable nanoparticle based influenza vaccine using a human precision cut lung slice technique.
Neuhaus V, Schwarz K, Klee A, Seehase S, Förster C, Pfennig O, Jonigk D, Fieguth HG, Koch W, Warnecke G, Yusibov V, Sewald K, Braun A. | PLoS One | 2013 | View |
Fundamental role for HIF-1α in constitutive expression of human β defensin-1.
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GAD65 autoantibodies detected by electrochemiluminescence assay identify high risk for type 1 diabetes.
Miao D, Guyer KM, Dong F, Jiang L, Steck AK, Rewers M, Eisenbarth GS, Yu L. | Diabetes | 2013 | View |
Gamma-Secretase Inhibitor Activity of a Pterocarpus erinaceus Extract.
Hage S, Marinangeli C, Stanga S, Octave JN, Quetin-Leclercq J, Kienlen-Campard P. | Neurodegener Dis. | 2013 | View |
Gene expression analysis and urinary biomarker assays reveal activation of tubulointerstitial injury pathways in a rodent model of chronic proteinuria (Doxorubicin nephropathy).
Cianciolo R, Yoon L, Krull D, Stokes A, Rodriguez A, Jordan H, Cooper D, Falls JG, Cullen J, Kimbrough C, Berridge B. | Nephron Exp Nephrol. | 2013 | View |
Generation and characterization of fully human monoclonal antibodies against human Orai1 for autoimmune disease.
Lin FF, Elliott R, Colombero A, Gaida K, Kelley L, Moksa A, Ho SY, Bykova E, Wong M, Rathanaswami P, Hu S, Sullivan JK, Nguyen HQ, McBride HJ. | J Pharmacol Exp Ther | 2013 | View |
GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in rats.
Habegger KM, Heppner KM, Amburgy SE, Ottaway N, Holland J, Raver C, Bartley E, Müller TD, Pfluger PT, Berger J, Toure M, Benoit SC, Dimarchi RD, Perez-Tilve D, D'Alessio DA, Seeley RJ, Tschöp MH. | Diabetes. | 2013 | View |
Glucagon-like peptide-1 receptor agonist treatment reduces beta cell mass in normoglycaemic mice.
Ellenbroek JH, Töns HA, Westerouen van Meeteren MJ, de Graaf N, Hanegraaf MA, Rabelink TJ, Carlotti F, de Koning EJ. | Diabetologia | 2013 | View |
Glucose metabolism in the Belgrade rat, a model of iron-loading anemia.
Jia X, Kim J, Veuthey T, Lee CH, Wessling-Resnick M. | Am J Physiol Gastrointest Liver Physiol. | 2013 | View |
Glutathione S-transferase P1 Ile105Val polymorphism modulates allergen-induced airway inflammation in human atopic asthmatics in vivo
Hoskins A, Wu P, Reiss S, Dworski R. | Clinical & Experimental Allergy | 2013 | View |
Glycemic, insulinemic, and appetite responses of patients with type 2 diabetes to commonly consumed breads.
Breen C, Ryan M, Gibney MJ, Corrigan M, O'Shea D. | Diabetes Educ | 2013 | View |
GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes.
Nohr MK, Pedersen MH, Gille A, Egerod KL, Engelstoft MS, Husted AS, Sichlau RM, Grunddal KV, Seier Poulsen S, Han S, Jones RM, Offermanns S, Schwartz TW. | Endocrinology | 2013 | View |
GSK256073, a selective agonist of G-protein coupled receptor 109A (GPR109A) reduces serum glucose in subjects with type 2 diabetes mellitus.
Dobbins RL, Shearn SP, Byerly RL, Gao FF, Mahar KM, Napolitano A, Nachbaur GJ, Le Monnier de Gouville AC. | Diabetes Obes Metab. | 2013 | View |
Helicobacter pylori-induced disruption of monolayer permeability and proinflammatory cytokine secretion in polarized human gastric epithelial cells.
Fiorentino M, Ding H, Blanchard TG, Czinn SJ, Sztein MB, Fasano A. | Infect Immun | 2013 | View |
Heparanase mediates renal dysfunction during early sepsis in mice.
Lygizos MI, Yang Y, Altmann CJ, Okamura K, Hernando AA, Perez MJ, Smith LP, Koyanagi DE, Gandjeva A, Bhargava R, Tuder RM, Faubel S, Schmidt EP. | Physiol Rep. | 2013 | View |
High apolipoprotein E in cerebrospinal fluid of patients with Lewy body disorders is associated with dementia.
Vijayaraghavan S, Maetzler W, Reimold M, Lithner CU, Liepelt-Scarfone I, Berg D, Darreh-Shori T. | Alzheimers Dement. | 2013 | View |
Higher levels of advanced glycation endproducts in human carotid atherosclerotic plaques are associated with a rupture-prone phenotype.
Hanssen NM, Wouters K, Huijberts MS, Gijbels MJ, Sluimer JC, Scheijen JL, Heeneman S, Biessen EA, Daemen MJ, Brownlee M, de Kleijn DP, Stehouwer CD, Pasterkamp G, Schalkwijk CG. | Eur Heart J. | 2013 | View |
High-fat feeding rapidly induces obesity and lipid derangements in C57BL/6N mice.
Podrini C, Cambridge EL, Lelliott CJ, Carragher DM, Estabel J, Gerdin AK, Karp NA, Scudamore CL; Sanger Mouse Genetics Project, Ramirez-Solis R, White JK. | Mamm Genome | 2013 | View |
HMGB1 mediates splenomegaly and expansion of splenic CD11b+ Ly-6Chigh inflammatory monocytes in murine sepsis survivors.
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Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway.
Lee JC, Espéli M, Anderson CA, Linterman MA, Pocock JM, Williams NJ, Roberts R, Viatte S, Fu B, Peshu N, Hien TT, Phu NH, Wesley E, Edwards C, Ahmad T, Mansfield JC, Gearry R, Dunstan S, et al. | Cell | 2013 | View |
Hyperglycemia associated with pasireotide:results from a mechanistic study in healthy volunteers.
Henry RR, Ciaraldi TP, Armstrong D, Burke P, Ligueros-Saylan M, Mudaliar S. | J Clin Endocrinol Metab. | 2013 | View |
Hyperglycosylated human chorionic gonadotropin as an early predictor of pregnancy outcomes after in vitro fertilization.
Chuan S, Homer M, Pandian R, Conway D, Garzo G, Yeo L, Su HI. | Fertility and Sterility | 2013 | View |
Identification of TLR10 as a Key Mediator of the Inflammatory Response to Listeria monocytogenes in Intestinal Epithelial Cells and Macrophages.
Regan T, Nally K, Carmody R, Houston A, Shanahan F, Macsharry J, Brint E. | J Immunol. | 2013 | View |
Identification of an HIV-1 Clade A Envelope that exhibits broad antigenicity and neutralization sensitivity and elicits antibodies targeting 3 distinct epitopes.
Hoffenberg S, Powell R, Carpov A, Wagner D, Wilson A, Kosakovsky Pond S, Lindsay R, Arendt H, Destefano J, Phogat S, Poignard P, Fling SP, Simek M, Labranche C, Montefiori D, Wrin T, Phung P, Burton D, Koff W, King CR, Parks CL, Caulfield MJ. | J Virol | 2013 | View |
Identification of benzimidazole diamides as selective inhibitors of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway
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Idiopathic normal-pressure hydrocephalus: Pathophysiology and diagnosis by CSF biomarkers.
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IFN-γ production by amyloid β-specific Th1 cells promotes microglial activation and increases plaque burden in a mouse model of Alzheimer's disease.
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IL-33 is more potent than IL-25 in provoking IL-13-producing nuocytes (type 2 innate lymphoid cells) and airway contraction.
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Imatinib treatment and Aβ42 in humans.
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Immune and inflammation responses to a 3-day period of intensified running versus cycling.
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Immune dysregulation and glucocorticoid resistance in minority and low income pregnant women.
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