IL-13

Interleukin-13 (IL-13) is a glycosylated immunoregulatory cytokine with two internal disulfide bonds. IL-13 is secreted by a variety of immune cells. IL-13 is involved in a number of biological processes, such as positive regulation of B-cell proliferation, macrophage activation, immunoglobulin production, protein secretion, and phosphorylation of Stat6 protein. IL-13 initially interacts with IL-13 Rα1 to form a low affinity complex. The formation of this complex triggers association with IL-4 Rα to form a high affinity complex which also functions as the type 2 IL-4 receptor complex. IL-13 also binds with high affinity to IL-13 Rα2 which is expressed as soluble intracellular protein and also on the cell surface. IL-13 is involved in number of disorders including allergic rhinitis, inflammatory bowel disease, and colorectal cancer.

 

IL-13 Singleplex Products

Our IL-13 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of IL-13. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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IL-13 Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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