V-PLEX Plus Human IL-13 Kit


Human interleukin-13 (IL-13) is a 15.8 kDa, glycosylated monomeric cytokine with two internal disulfide bonds. It is secreted by a variety of immune cells. IL-13 is involved in a number of biological processes, such as positive regulation of B-cell proliferation, macrophage activation, immunoglobulin production, protein secretion, and phosphorylation of Stat6 protein. IL-13 initially interacts with IL-13 Rα1 to form a low-affinity complex. The formation of this complex triggers association with IL-4 Rα to form a high-affinity complex that also functions as the type 2 IL-4 receptor complex. IL-13 also binds with high affinity to IL-13 Rα2, which is expressed as a soluble intracellular protein, and also on the cell surface. It is involved in a number of disorders including allergic rhinitis, inflammatory bowel disease, and colorectal cancer. The Human IL-13 Kit provides the assay-specific components for the quantitative determination of endogenous IL-13 in human urine, serum, plasma, and cell culture supernatants.

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25 plates
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