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Immunisation with ID83 fusion protein induces antigen-specific cell mediated and humoral immune responses in cattle.
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Inhibition of nuclear factor of activated T-cells (NFAT) suppresses accelerated atherosclerosis in diabetic mice.
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Interleukin-6 Receptor Polymorphism Is Prevalent in HIV-negative Castleman Disease and Is Associated with Increased Soluble Interleukin-6 Receptor Levels.
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Mechanistic pharmacokinetic-pharmacodynamic modeling of BACE1 inhibition in monkeys: development of a predictive model for amyloid precursor protein processing.
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Microchannel acoustophoresis does not impact survival or function of microglia, leukocytes or tumor cells.
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miR-199a-5p Silencing Regulates the Unfolded Protein Response in COPD and α1 Antitrypsin Deficiency.
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Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons.
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Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance.
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Multimodal microvascular imaging reveals that selective inhibition of class I PI3K is sufficient to induce an antivascular response.
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Nasal levels of soluble IL-33R ST2 and IL-16 in allergic rhinitis: inverse correlation trends with disease severity.
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New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF.
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NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.
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Nucleotide-binding oligomerization domain 2 signaling promotes hyperresponsive macrophages and colitis in IL-10-deficient mice.
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Osteoarthritis year 2013 in review: Biomarkers; reflecting before moving forward, one step at a time.
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Ozone induces glucose intolerance and systemic metabolic effects in young and aged brown Norway rats.
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Parenteral immunization with IpaB/IpaD protects mice against lethal pulmonary infection by Shigella.
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Patients with sepsis exhibit mitochondrial biogenesis in peripheral blood immune cells.
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Pharmacokinetics and safety of golimumab in healthy chinese subjects following a single subcutaneous administration in a randomized phase I trial.
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Pharmacokinetics, biocompatibility and bioavailability of a controlled release monoclonal antibody formulation.
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Pharmacology of AMG 181, a human anti-α(4) β(7) antibody that specifically alters trafficking of gut-homing T cells.
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Phase I study of Ofatumumab, a human anti-CD20 antibody, in Japanese patients with relapsed or refractory chronic lymphocytic leukemia and small lymphocytic lymphoma.
Ogura M, Hatake K, Tobinai K, Uchida T, Suzuki T, Terui Y, Yokoyama M, Maruyama D, Mori M, Jewell RC, Katsura K, Hotta T. | Jpn J Clin Oncol | 2013 | View |
Phase I study of Dovitinib (TKI258), an oral FGFR, VEGFR, and PDGFR inhibitor, in advanced or metastatic renal cell carcinoma.
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Phase II study evaluating 2 dosing schedules of oral Foretinib (GSK1363089), cMET/VEGFR2 inhibitor, in patients with metastatic gastric cancer.
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Phase II study of a neutrophil elastase inhibitor (AZD9668) in patients with bronchiectasis.
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PI3K-δ and PI3K-γ Inhibition by IPI-145 Abrogates Immune Responses and Suppresses Activity in Autoimmune and Inflammatory Disease Models.
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Population pharmacokinetics of belimumab following intravenous administration in patients with systemic lupus erythematosus.
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Preclinical Evaluation of the Toxicological Effects of a Novel Constrained Ethyl Modified Antisense Compound Targeting Signal Transducer and Activator of Transcription 3 in Mice and Cynomolgus Monkeys.
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Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells.
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Proinflammatory cytokines and the clinical features of dementia with Lewy Bodies.
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Puerperal mastitis: a reproductive event of importance affecting anti-mucin antibody levels and ovarian cancer risk.
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Purification of monoclonal antibodies by hydrophobic interaction chromatography under no-salt conditions.
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Quinine controls body weight gain without affecting food intake in male C57BL6 mice.
Cettour-Rose P, Bezençon C, Darimont C, le Coutre J, Damak S. | BMC Physiol | 2013 | View |
Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults.
Patel MJ, Batch BC, Svetkey LP, Bain JR, Turer CB, Haynes C, Muehlbauer MJ, Stevens RD, Newgard CB, Shah SH. | OMICS | 2013 | View |
RAF inhibitors activate the MAPK pathway by relieving inhibitory autophosphorylation.
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Reductions in serum IGF-1 during aging impair health span.
Gong Z, Kennedy O, Sun H, Wu Y, Williams GA, Klein L, Cardoso L, Matheny RW Jr, Hubbard GB, Ikeno Y, Farrar RP, Schaffler MB, Adamo ML, Muzumdar RH, Yakar S. | Aging Cell | 2013 | View |
Relationship between Carotid Intima Media Thickness and Helminth Infections on Flores Island, Indonesia.
Wiria AE, Wammes LJ, Hamid F, Dekkers OM, Prasetyani MA, May L, Kaiser MMM, Verweij JJ, Tamsma JT, Partono S, Sartono E, Supali T, Yazdanbakhsh M, Smit JWA. | PLoS One | 2013 | View |
Renal inflammatory markers during the onset of hypertension in spontaneously hypertensive rats.
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Reproductive toxicity of denosumab in cynomolgus monkeys.
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Requirement of apoptosis-inducing kinase 1 for the induction of bronchial asthma following stimulation with ovalbumin.
Takada E. Furuhata M, Nakae S, Ichijo H, Sudo K, Mizuguchi J. | Int Arch Allergy Immunol. | 2013 | View |
Resveratrol protects against atherosclerosis, but does not add to the antiatherogenic effect of atorvastatin, in APOE*3-Leiden.CETP mice.
Berbée JF, Wong MC, Wang Y, van der Hoorn JW, Khedoe PP, van Klinken JB, Mol IM, Hiemstra PS, Tsikas D, Romijn JA, Havekes LM, Princen HM, Rensen PC. | J Nutr Biochem. 2013 Aug;24(8):1423-30 | 2013 | View |
Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rats.
Stemmer K, Bielohuby M, Grayson BE, Begg DP, Chambers AP, Neff C, Woods SC, Erben RG, Tschöp MH, Bidlingmaier M, Clemens TL, Seeley RJ. | Endocrinology | 2013 | View |
S49076 is a novel kinase inhibitor of MET, AXL and FGFR with strong preclinical activity alone and in association with bevacizumab.
Burbridge MF, Bossard CJ, Saunier C, Fejes I, Bruno A, Leonce S, Ferry G, Da Violante G, Bouzom F, Cattan V, Jacquet-Bescond A, Comoglio PM, Lockhart BP, Boutin JA, Cordi A, Ortuno JC, Pierre A, Hickman JA, Cruzalegui FH, Depil S. | Mol Cancer Ther. | 2013 | View |
Safety and Immunogenicity of a Live Attenuated RSV Vaccine in Healthy RSV-Seronegative Children 5 to 24 Months of Age.
Malkin E, Yogev R, Abughali N, Sliman J, Wang CK, Zuo F, Yang CF, Eickhoff M, Esser MT, Tang RS, Dubovsky F. | PLoS One | 2013 | View |
Safety, pharmacokinetics, and pharmacodynamic effects of a selective TGR5 agonist, SB-756050, in type 2 diabetes.
Hodge RJ, Lin J, Johnson LSV, Gould EP, Bowers GD, Nunex DJ. | Clinical Pharmacology in Drug Development | 2013 | View |
Safety, tolerability and pharmacokinetics of a human anti-interleukin-13 monoclonal antibody (CNTO 5825) in an ascending single-dose first-in-human study.
van Hartingsveldt B, Nnane IP, Bouman-Thio E, Loza MJ, Piantone A, Davis HM, Petty KJ. | Br J Clin Pharmacol. | 2013 | View |
Salivary cytokines in healthy adolescent girls: Intercorrelations, stability, and associations with serum cytokines, age, and pubertal stage.
Riis JL, Out D, Dorn LD, Beal SJ, Denson LA, Pabst S, Jaedicke K, Granger DA. | Dev Psychobiol. | 2013 | View |
SAR investigations on a novel class of gamma-secretase modulators based on a unique scaffold
Austin WF, Hubbs JL, Fuller NO, Creaser SP, McKee TD, Loureiro RMB, Findeis MA, Tate B, Ives JL, Bronk BS. | Med Chem Comm | 2013 | View |
Sarcoidosis, alveolar β-Actin and pulmonary fibrosis.
Cooke G, Govender P, Watson CJ, Armstrong ME, Keane MP, King R, Tynan A, Dunn M, Donnelly SC. | QJM | 2013 | View |
Secretory leukocyte protease inhibitor: A pivotal mediator of anti-inflammatory responses in acetaminophen induced acute liver failure.
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Christian LM, Iams J, Porter K, Leblebicioglu B. | Ann Behav Med. | 2013 | View |
Serum folate receptor alpha, mesothelin and megakaryocyte potentiating factor in ovarian cancer: association to disease stage and grade and comparison to CA125 and HE4.
O'Shannessy DJ, Somers EB, Palmer LM, Thiel RP, Oberoi P, Heath R, Marcucci L. | J Ovarian Res | 2013 | View |
Serum levels of IL-6 and IL-1β can predict the efficacy of gemcitabine in patients with advanced pancreatic cancer.
Mitsunaga S, Ikeda M, Shimizu S, Ohno I, Furuse J, Inagaki M, Higashi S, Kato H, Terao K, Ochiai A. | Br J Cancer | 2013 | View |
Serum lysyl oxidase like-2 levels and idiopathic pulmonary fibrosis disease progression.
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Serum proinflammatory cytokine responses to Influenza virus vaccine among women during pregnancy versus non-pregnancy.
Christian LM, Porter K, Karlsson E, Schultz-Cherry S, Iams JD. | Am J Reprod Immunol. | 2013 | View |
Shedding LIGHT (TNFSF14) on the tumor microenvironment of colorectal cancer liver metastases.
Qin JZ, Upadhyay V, Prabhakar B, Maker AV. | J Transl Med | 2013 | View |
SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes.
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Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity.
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Suppression of DHT-induced paracrine stimulation of endothelial cell growth by estrogens via prostate cancer cells.
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Susceptibility of adult and senescent Brown Norway rats to repeated ozone exposure: an assessment of behavior, serum biochemistry and cardiopulmonary function.
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T Cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia.
Fogli LK, Sundrud MS, Goel S, Bajwa S, Jensen K, Derudder E, Sun A, Coffre M, Uyttenhove C, Van Snick J, Schmidt-Supprian M, Rao A, Grunig G, Durbin J, Casola SS, Rajewsky K, Koralov SB. | J Immunol. | 2013 | View |
Targeting IGF-IR with ganitumab inhibits tumorigenesis and increases durability of response to androgen-deprivation therapy in VCaP prostate cancer xenografts.
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