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Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo.
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FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/β-Klotho bispecific protein.
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GSK256073, a selective agonist of G-protein coupled receptor 109A (GPR109A) reduces serum glucose in subjects with type 2 diabetes mellitus.
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High-fat feeding rapidly induces obesity and lipid derangements in C57BL/6N mice.
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Maternal ileal interposition surgery confers metabolic improvements to offspring independent of effects on maternal body weight in UCD-T2DM rats.
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Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rats.
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The DPP-4 inhibitor linagliptin restores &beta-cell function & survival in human isolated islets through GLP-1 stabilization.
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2-Aminoadipic acid is a biomarker for diabetes risk.
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Critical Appraisal of Four IL-6 Immunoassays.
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Effect of Sitagliptin on post-prandial glucagon and GLP-1 levels in patients with type 1 diabetes: Investigator-initiated, double-blind, randomized, placebo-controlled trial.
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Evaluation of body fat composition after linagliptin treatment in a rat model of diet-induced obesity: a magnetic resonance spectroscopy study in comparison with sibutramine.
Klein T, Niessen HG, Ittrich C, Mayoux E, Mueller HP, Cheetham S, Stiller D, Kassubek J, Mark M. | Diabetes Obes Metab. | 2012 | View |
Functionally convergent white adipogenic progenitors of different lineages participate in a diffused system supporting tissue regeneration.
Lemos DR, Paylor B, Chang C, Sampaio A, Underhill TM, Rossi FM. | Stem Cells | 2012 | View |
Gastric Bypass Surgery Attenuates Ethanol Consumption in Ethanol-Preferring Rats.
Davis JF, Schurdak JD, Magrisso IJ, Mul JD, Grayson BE, Pfluger PT, Tschoep MH, Seeley RJ, Benoit SC. | Biol Psychiatry. | 2012 | View |
GIP-overexpressing mice demonstrate reduced diet-induced obesity and steatosis, and improved glucose homeostasis.
Kim S, Nian C, Karunakaran S, Clee SM, Isales CM, McIntosh CHS. | PLoS One | 2012 | View |
Hepatic Deletion of SIRT1 Decreases Hepatocyte Nuclear Factor 1alpha/Farnesoid X Receptor Signaling and Induces Formation of Cholesterol Gallstones in Mice.
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Inhibition of malonyl-CoA decarboxylase reduces the inflammatory response associated with insulin resistance.
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Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase.
Talukdar S, Oh DY, Bandyopadhyay G, Li D, Xu J, McNelis J, Lu M, Li P, Yan Q, Zhu Y, Ofrecio J, Lin M, Brenner MB, Olefsky JM. | Nat Med. | 2012 | View |
Novel Biological Action of the Dipeptidylpeptidase-IV Inhibitor, Sitagliptin, as a Glucagon-Like Peptide-1 Secretagogue.
Sangle GV, Lauffer LM, Grieco A, Trivedi S, Iakoubov R, Brubaker PL. | Endocrinology. | 2012 | View |
Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release – potential insight into mechanism of action.
Liu J, Gorski J, Gold SJ, Chen D, Chen S, Forrest G, Itoh Y, Marsh D, McLaren D, Shen Z, Sonatore L, Carballo-Jane E, Craw S, Guan X, Karanam B, Sakaki J, Szeto D, Tong X, Xiao J, Yoshimoto R, Yu H, Balkovec J, Pinto S. | Obesity | 2012 | View |
Rationale-based engineering of a potent long-acting FGF21 analog for the treatment of type 2 diabetes
Hecht R, Li Y, Sun J, Belouski E, Hall M, Hager T, Yie J, Wang W, Winters D, Smith S, Spahr C, Tam L, Shen Z, Stanislaus S, Chinookoswong N, Lau Y, Sickmier A, Michaels ML, Boone T, Veniant MM, Xu J. | PLoS One | 2012 | View |
Restriction of dietary energy intake has a greater impact on bone integrity than does restriction of calcium in exercising female rats.
Swift SN, Baek K, Swift JM, Bloomfield SA. | J Nutr. | 2012 | View |
Role of fatty acid transport protein 4 in oleic acid-induced glucagon-like peptide-1 secretion from murine intestinal L cells.
Poreba MA, Dong CX, Li SK, Stahl A, Miner JH, Brubaker PL. | Am J Physiol Endocrinol Metab. | 2012 | View |
Short-term effects of air temperature on blood markers of coagulation and inflammation in potentially susceptible individuals.
Schauble CL, Hampel R, Breitner S, Rückerl R, Phipps R, Diaz-Sanchez D, Devlin RB, Carter JD, Soukup J, Silbajoris R, Dailey L, Koenig W, Cyrys J, Geruschkat U, Belcredi P, Kraus U, Peters A, Schneider AE. | Occup Environ Med. | 2012 | View |
Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion.
Kyriazis GA, Soundarapandian MM, Tyrberg B. | Proc Natl Acad Sci U S A. | 2012 | View |
The Dipeptidyl Peptidase-4 Inhibitor Linagliptin Attenuates Inflammation and Accelerates Epithelialization in Wounds of Diabetic ob/ob Mice.1
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The DPP-4 inhibitor Linagliptin counteracts stroke in the normal and diabetic mouse brain: a comparison with Glimepiride.
Darsalia V, Ortsater H, Olverling A, Darlöf E, Wolbert P, Nystrom T, Klein T, Sjoholm A, Patrone C. | Diabetes | 2012 | View |
The glucose-lowering effects of the PDE4 inhibitors roflumilast and roflumilast-N-oxide in db/db mice.
Vollert S, Kaessner N, Heuser A, Hanauer G, Dieckmann A, Knaack D, Kley HP, Beume R, Weiss-Haljiti C. | Diabetologia. | 2012 | View |
The Wnt signaling pathway effector TCF7L2 controls gut and brain proglucagon gene expression and glucose homeostasis.
Shao W, Wang D, Chiang YT, Ip W, Zhu L, Xu F, Columbus J, Belsham DD, Irwin DM, Zhang H, Wen X, Wang Q, Jin T. | Diabetes. | 2012 | View |
Transcriptional factor regulatory factor X 6 (Rfx6) increases gastric inhibitory polypeptide (GIP) expression in enteroendocrine K-cells and is involved in GIP hypersecretion in high-fat diet-induced obesity.
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A pilot study to assess whether glucagon-like Peptide-1 protects the heart from ischemic dysfunction and attenuates stunning after coronary balloon occlusion in humans.
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Cardioprotection against ischaemia induced by dobutamine stress using glucagon-like peptide-1 in patients with coronary artery disease.
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Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease.
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Comparison of the effects of n-3 long chain polyunsaturated fatty acids and fenofibrate on markers of inflammation and vascular function, and on the serum lipoprotein profile in overweight and obese subjects.
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Duodenal-jejunal bypass protects GK rats from {beta}-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-1.
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Effects of peripherally administered neuromedin U on energy and glucose homeostasis.
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E-Selectin is Elevated in Cord Blood of South Asian Neonates Compared with Caucasian Neonates.
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Essential Role for Protein Kinase C{zeta} in Oleic Acid-Induced Glucagon-Like Peptide-1 Secretion in Vivo in the Rat.
Iakoubov, R., Ahmed, A., Lauffer, L.M., Bazinet, R.P., Brubaker, P.L. | Endocrinology | 2011 | View |
Exchanging Saturated Fatty Acids for (n-6) Polyunsaturated Fatty Acids in a Mixed Meal May Decrease Postprandial Lipemia and Markers of Inflammation and Endothelial Activity in Overweight Men.
Masson, C.J., Mensink, R.P. | J Nutr. | 2011 | View |
GPR119 agonists mediate GLP-1 secretion from mouse enteroendocrine cells through glucose-independent pathways.
Lan, H., Lin, H.V., Wang, C.F., Wright, M.J., Xu, S., Kang, L., Juhl, K., Hedrick, J.A., Kowalski, T.J. | Br J Pharmacol. | 2011 | View |
Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2.
Jornayvaz, F.R., Birkenfeld, A.L., Jurczak, M.J., Kanda, S., Guigni, B.A., Jiang, D.C., Zhang, D., Lee, H.Y., Samuel, V.T., Shulman, G.I. | Proc Natl Acad Sci USA. | 2011 | View |