Dialysate interleukin-6 predicts increasing peritoneal solute transport rate in incident peritoneal dialysis patients.

Cho Y, Johnson DW, Vesey DA, Hawley CM, Pascoe EM, Clarke M, Topley N, and on behalf of the balANZ Trial Investigators.
Journal   BMC Nephrology
Species  
Analytes Measured   IL-6
Matrix Tested   Peritoneal dialysis lysate
Year   2014
Volume   15
Page Numbers  
Application   Cytokines and Chemokines
Abstract
Background: Repeated exposure to peritoneal dialysis (PD) solutions contributes to cumulative intraperitoneal inflammation and peritoneal injury. The present study aimed to explore the capacity of dialysate interleukin-6(IL-6) to a) predict peritoneal membrane function and peritonitis in incident PD patients, and b) to evaluate the influence of neutral pH, low glucose degradation product (GDP) PD solution on dialysate IL-6 levels.

Methods: The study included 88 incident participants from the balANZ trial who had completed 24-months of follow-up. Change in peritoneal solute transport rate (PSTR) and peritonitis were primary outcome measures, and the utility of IL-6 and IL-6 appearance rate (IL-6 AR) in predicting these outcomes was analyzed using multilevel linear regression and Cox proportional hazards models, respectively. Sensitivity analyses were performed by analyzing outcomes in a peritonitis-free cohort (n = 56).

Results: Dialysate IL-6 concentration significantly increased from baseline to 24 months (mean difference 19.07 pg/mL; P < 0.001) but was not affected by the type of PD solution received (P = 0.68). An increase in PSTR from baseline was associated with higher levels of IL-6 (P = 0.004), the use of standard solutions (P = 0.005) and longer PD duration (P < 0.001). Baseline IL-6 level was not associated with a shorter time to first peritonitis (adjusted hazard ratio 1.00, 95% CI 0.99-1.00, P = 0.74). Analysis of IL-6 AR as well as sensitivity analyses in a peritonitis-free cohort yielded comparable results.

Conclusion: Dialysate IL-6 concentration increased with longer PD duration and was a significant, independent predictor of PSTR. The use of biocompatible PD solutions exerted no significant effect on dialysate IL-6 levels but did abrogate the increase in PSTR associated with standard PD solutions. This is the first study to examine the impact of biocompatible solutions on the utility of IL-6 in predicting PSTR and peritonitis.

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Human  | Multiplex
V-PLEX Proinflammatory Panel 1 Mouse Kit
IFN-γ, IL-10, IL-12p70, IL-1β, IL-2, IL-4, IL-5, IL-6, KC/GRO, TNF-α
Mouse  | Multiplex
V-PLEX Proinflammatory Panel 1 Human Kit
IFN-γ, IL-10, IL-12p70, IL-13, IL-1β, IL-2, IL-4, IL-6, IL-8, TNF-α
Human  | Multiplex
Proinflammatory Panel 1 Human Control Pack
IL-10, IL-12p70, IL-13, IL-2, IL-4, IL-6, IL-8, IFN-γ, IL-1β, TNF-α
Human
Human ProInflammatory-4 II Tissue Culture Kit
IL-1β, IL-6, IL-8, TNF-α
Human  | Multiplex
Human IL-6 Tissue Culture Kit
IL-6
Human  | Singleplex
Human ProInflammatory 7-Plex Tissue Culture Kit
IFN-γ, IL-1β, IL-10, IL-12p70, IL-6, IL-8, TNF-α
Human  | Multiplex
Human ProInflammatory 9-Plex Tissue Culture Kit
GM-CSF, IFN-γ, IL-1β, IL-10, IL-12p70, IL-2, IL-6, IL-8, TNF-α
Human  | Multiplex
Human ProInflammatory-4 I Tissue Culture Kit
IFN-γ, IL-1β, IL-6, TNF-α
Human  | Multiplex
Canine ProInflammatory Panel 3 Ultra-Sensitive Kit
IL-2, IL-6, IL-8, TNF-α
Canine  | Multiplex
MA6000 Rat IL-6 384 Tissue Culture Kit
IL-6
Rat  | Singleplex
Mouse ProInflammatory 7-Plex Tissue Culture Kit
IL-10, IL-6, IL-12p70, IFN-γ, IL-1β, KC/GRO, TNF-α
Mouse  | Multiplex
MA6000 Mouse IL-6 384 Tissue Culture Kit
IL-6
Mouse  | Singleplex
Mouse IL-6 Tissue Culture Kit
IL-6
Mouse  | Singleplex
V-PLEX Mouse Cytokine 29-Plex Kit
IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-15, IL-16, IL-17A, IL-17C, IL-17F, IL-17A/F, IL-17E/IL-25, IL-21, IL-22, IL-23, IL-27p28/IL-30, IL-31, IL-33, IP-10, KC/GRO, MCP-1, MIP-1α, MIP-2, MIP-3α, TNF-α
Mouse  | Multiplex
U-PLEX Biomarker Group 1 NHP Assays
CTACK, Eotaxin, Eotaxin-2, Eotaxin-3, ENA-78, FLT3L, Fractalkine, G-CSF, I-309, IFN-α2a, IL-1β, IL-4, IL-5, IL-6, IL-8, IL-9, IL-10, IL-12p70, IL-13, IL-15, IL-17A, IL-17A/F, IL-17B, IL-17C, IL-17D, IL-17F, IL-18, IL-22, IL-23, IP-10, MCP-2, MCP-3, MCP-4, MDC, MIF, MIP-1α, MIP-3α, MIP-3β, MIP-5, SDF-1α, TARC, TGF-β1, TGF-β2, TGF-β3, TNF-α, TNF-β, TPO, TRAIL, VEGF-A, YKL-40, GM-CSF, GRO-α, IL-12/IL-23p40, IL-16, IL-1RA, IL-1α, IL-2Rα, IL-7, I-TAC, MCP-1, MIP-1β
Non-human primate
V-PLEX Plus Mouse Cytokine 29-Plex Kit
IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-15, IL-16, IL-17A, IL-17C, IL-17F, IL-17A/F, IL-17E/IL-25, IL-21, IL-22, IL-23, IL-27p28/IL-30, IL-31, IL-33, IP-10, KC/GRO, MCP-1, MIP-1α, MIP-2, MIP-3α, TNF-α
Mouse  | Multiplex
MA6000 Human IL-6 384 Tissue Culture Kit
IL-6
Human  | Singleplex
MS6000 Human ProInflammatory-4 II 384 Tissue Culture Kit
IL-6, IL-8
Human  | Multiplex
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