R-PLEX Rat IL-6 Antibody Set Overview The R-PLEX Rat IL-6 Antibody Set includes a matched capture and detection antibody pair and calibrator for the quick and easy measurement of IL-6 in biological samples. R-PLEX products leverage MSD’s electrochemiluminescence technology for better sensitivity and a larger dynamic range than traditional ELISAs. R-PLEX matched antibody sets enable the development of singleplex and multiplex immunoassays. Individual assays may be developed using MSD avidin- or streptavidin-coated plates. Custom multiplex assays with any combination of R-PLEX analytes can be developed on U-PLEX MULTI-SPOT plates. To learn more about the advantages of R-PLEX products
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R-PLEX Rat IL-6 Antibody Set Features - Measures rat IL-6 in Serum, Plasma
- Dynamic range: 40 - 150,000 pg/mL
- Median LLOD: 40 pg/mL
- Can be used to develop individual analyte assays as well as multiplex panels
Typical Data Calibration curve for the R-PLEX Rat IL-6 Antibody Set was assessed and representative data is presented below.
Figure 1. R-PLEX Rat IL-6 Antibody Set Calibration Curve 
IL-6 Analyte
Description - Interleukin-6 (IL-6, B-cell stimulatory factor 2, BSF-2, CTL differentiation factor, CDF, hybridoma growth factor, Interferon beta-2, IFN-β2) is secreted mainly by T cells and macrophages. IL-6 is involved in inflammation, aging, cell growth, apoptosis, and bone remodeling and is released from muscle cells during exercise. IL-6 induces acute phase response and plays an essential role in differentiating B cells into IgG secreting cells.
Application Area - Autoimmune and Inflammation, Cardiovascular Disease, Neurodegenerative
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Recommended Components
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Specifications
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Kit Contents
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References
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Documentation
You will need plates, diluents, and read buffer to run your assay. Please select from the below menu.
R-PLEX Sets are intended to be used with other MSD components such as plates, diluents and MSD Read Buffer. If you don’t already have these items, you can purchase them along with your Antibody Set(s). The “Recommended Components” tab provides helpful suggestions or you can call MSD Customer Service (Phone number) for assistance. R-PLEX Sets can also be used with other antibody sets such as U-PLEX antibody sets (make a link to UPLEX landing page) for multiplex measurements.
Catalog No.
Product Name
Size
R50AA-4
R92TG-3
L45SA-1
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Application(s)
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Immunology/Inflammation
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Analyte(s)
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IL-6
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Species
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Rat
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Capture Antibody
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Mouse Monoclonal
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Detection Antibody
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Mouse Monoclonal
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Dynamic Range
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39.6-150,000 pg/mL
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Sample Type
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Serum, Plasma
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Recombinant standards
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Recombinant Expressed in E.coli
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LLOD (Sensitivity)
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39.6 pg/mL
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Storage Statement(s)
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Please refer to the product insert for the storage conditions of individual kit components.
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Storage Condition
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Multi-Component
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Gene ID(s)
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24498
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UniProt ID(s)
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P20607
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Assay Diluent(s)
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Diluent 42
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Antibody Diluent(s)
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Diluent 40
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Product Description
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Storage
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Quantity per Kit
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Rat IL-6 Antibody Set (5 Plate Size)
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2-8°C
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1 ea
(5 plate size)
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Rat IL-6 Calibrator
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≤-70°C
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5 vial
(1 vial)
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Product Description
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Storage
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Quantity per Kit
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Rat IL-6 Antibody Set (5 Plate Size)
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2-8°C
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10 ea
(5 plate size)
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Rat IL-6 Calibrator
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≤-70°C
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50 vial
(1 vial)
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Title
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Journal
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Year
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Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial
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Cytokine biomarkers in tear film for primary open-angle glaucoma
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Kinetics and Biomarkers of Severe Cytokine Release Syndrome after CD19 Chimeric Antigen Receptor-modified T Cell Therapy.
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A Pilot Study of Preoperative Single-Dose Ipilimumab and/or Cryoablation in Women with Early-Stage Breast Cancer with Comprehensive Immune Profiling.
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Dialysate interleukin-6 predicts increasing peritoneal solute transport rate in incident peritoneal dialysis patients.
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Product Inserts
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SDS
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Handouts
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Datasheets
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