R-PLEX Rat IL-6 Antibody Set Overview The R-PLEX Rat IL-6 Antibody Set includes a matched capture and detection antibody pair and calibrator for the quick and easy measurement of IL-6 in biological samples. R-PLEX products leverage MSD’s electrochemiluminescence technology for better sensitivity and a larger dynamic range than traditional ELISAs. R-PLEX matched antibody sets enable the development of singleplex and multiplex immunoassays. Individual assays may be developed using MSD avidin- or streptavidin-coated plates. Custom multiplex assays with any combination of R-PLEX analytes can be developed on U-PLEX MULTI-SPOT plates. To learn more about the advantages of R-PLEX products
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R-PLEX Rat IL-6 Antibody Set Features - Measures rat IL-6 in Serum, Plasma
- Dynamic range: 40 - 150,000 pg/mL
- Median LLOD: 40 pg/mL
- Can be used to develop individual analyte assays as well as multiplex panels
Typical Data Calibration curve for the R-PLEX Rat IL-6 Antibody Set was assessed and representative data is presented below.
Figure 1. R-PLEX Rat IL-6 Antibody Set Calibration Curve 
IL-6 Analyte
Description - Interleukin-6 (IL-6, B-cell stimulatory factor 2, BSF-2, CTL differentiation factor, CDF, hybridoma growth factor, Interferon beta-2, IFN-β2) is secreted mainly by T cells and macrophages. IL-6 is involved in inflammation, aging, cell growth, apoptosis, and bone remodeling and is released from muscle cells during exercise. IL-6 induces acute phase response and plays an essential role in differentiating B cells into IgG secreting cells.
Application Area - Autoimmune and Inflammation, Cardiovascular Disease, Neurodegenerative
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Recommended Components
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Specifications
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Kit Contents
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References
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Resources
You will need plates, diluents, and read buffer to run your assay.
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Catalog No.
Product Name
Size
L45SA-1
R50AA-4
R92TG-3
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Application(s)
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Immunology/Inflammation
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Analyte(s)
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IL-6
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Species
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Rat
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Capture Antibody
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Mouse Monoclonal
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Detection Antibody
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Mouse Monoclonal
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Dynamic Range
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39.6-150,000 pg/mL
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Sample Type
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Serum, Plasma
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Recombinant standards
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Recombinant Expressed in E.coli
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LLOD (Sensitivity)
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39.6 pg/mL
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Storage Statement
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Please refer to the product insert for the storage conditions of individual kit components.
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Storage Condition
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Multi-Component
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Gene ID
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24498
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UniProt ID
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P20607
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Assay Diluent(s)
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Diluent 42
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Antibody Diluent(s)
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Diluent 40
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Product Description
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Storage
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Quantity per Kit
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Rat IL-6 Antibody Set (5 Plate Size)
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2-8°C | 1 ea
(5 plate size) |
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Rat IL-6 Calibrator
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≤-70°C | 5 vial
(1 vial) |
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Product Description
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Storage
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Quantity per Kit
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Rat IL-6 Antibody Set (5 Plate Size)
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2-8°C | 10 ea
(5 plate size) |
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Rat IL-6 Calibrator
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≤-70°C | 50 vial
(1 vial) |
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Title
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Journal
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Year
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Cytokine biomarkers in tear film for primary open-angle glaucoma
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Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial
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Kinetics and Biomarkers of Severe Cytokine Release Syndrome after CD19 Chimeric Antigen Receptor-modified T Cell Therapy.
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A Pilot Study of Preoperative Single-Dose Ipilimumab and/or Cryoablation in Women with Early-Stage Breast Cancer with Comprehensive Immune Profiling.
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Dialysate interleukin-6 predicts increasing peritoneal solute transport rate in incident peritoneal dialysis patients.
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