U-PLEX Mouse IL-6 Assay


MSD offers a range of individual assays utilizing U-PLEX Antibody Sets that provide a rapid and convenient method for measuring biomarkers in complex matrices. The individual assays are offered on MSD GOLD Small Spot Streptavidin Plates and use the same antibody sets and diluents as the U-PLEX multiplex assays. This allows for efficient transfer between the individual assay and a higher throughput multiplex configuration. Typical of assays developed on the MSD platform, the individual assays have high sensitivity, excellent precision, provide up to five-logs of linear dynamic range, and require minimal sample volume. Mouse interleukin-6 (IL-6) is a 24.4 kDa cytokine with two disulfide bonds that is secreted mainly by T cells and macrophages. It is involved in numerous biological processes including inflammation, aging, cell growth, apoptosis, and bone remodeling. It is released from muscle cells during exercise in response to muscle contraction. IL-6 induces an acute phase response and plays an essential role in differentiating B cells into immunoglobulin-secreting cells. The receptor for IL-6 consists of a ligand-binding subunit (IL-6R) and a signal-transducing subunit (gp130) that is also a component of other protein receptors. IL-6 binding to IL-6R triggers the binding of the IL-6-receptor complex to gp130 and the homodimerization of gp130. IL-6 is involved in osteoporosis, pulmonary fibrosis, liver cirrhosis, ischemia, and berylliosis, among other disorders. The U-PLEX Mouse IL-6 Assay provides the components for the quantitative determination of both natural and recombinant IL-6 in serum, plasma, and cell culture supernatants.

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1 plate
5 plates
25 plates
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