Cartilage and bone markers and inflammatory cytokines are increased in synovial fluid in the acute phase of knee injury (hemarthrosis) - a cross-sectional analysis.

Sward P, Frobell R, Englund M, Roos H, Struglics A.
Journal   Osteoarthritis Cartilage.
Species  
Analytes Measured   IL-6 , IL-8 , Osteocalcin , Osteopontin , Osteonectin
Matrix Tested   Synovial fluid
Year   2012
Volume   20
Page Numbers   1302-1308
Application   Bone Metabolism , Cytokines and Chemokines
Abstract
PURPOSE: The aim of this cross-sectional study was to investigate concentrations of cartilage and bone markers, and pro-inflammatory cytokines in synovial fluid (SF) collected at different time-points from acutely injured knees with hemarthrosis and to compare these with SF concentrations of knees of age and gender-matched healthy reference subjects.

METHODS: SF was aspirated from the acutely injured knee of 111 individuals (mean age 27 years, span 13-64 years, 22% women). Concentrations of sulfated glycosaminoglycan (sGAG) were measured by Alcian blue precipitation whereas cartilage ARGS, bone biomarkers [osteocalcin (OCL), secreted protein acidic and rich in cysteine (SPARC) and osteopontin (OPN)] and pro-inflammatory cytokines [interleukin (IL)-1β, IL-6, IL-8 and tumor necrosis factor (TNF)-α] were analyzed using electrochemiluminescence. Samples were also analyzed with regard to time between injury and aspiration [same day (n = 29), 1 day (n = 31), 2-3 days (n = 19), 4-7 days (n = 20) and 8-23 days (n = 12)].

RESULTS: SF concentrations of ARGS (P < 0.001), SPARC (P < 0.001), OPN (P < 0.001), and all cytokines (P < 0.001), but not sGAG (P = 0.06) or OCL (P = 0.992), were significantly higher in injured knees compared to knees of reference subjects. The cartilage markers sGAG and ARGS were significantly higher in knees aspirated later than 1 day after injury, whereas concentrations of SPARC and OPN and all cytokines were higher in knees aspirated the same day as the injury and at all time-points thereafter.

CONCLUSIONS: Our results suggest that an acute knee injury is associated with an instant local biochemical response to the trauma, which may affect cartilage and bone as well as the inflammatory activity.

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V-PLEX Proinflammatory Panel 1 NHP Kit
IFN-γ, IL-10, IL-1β, IL-2, IL-6, IL-8
Non-human primate  | Multiplex
V-PLEX Neuroinflammation Panel 1 Human Kit
CRP, Eotaxin, Eotaxin-3, FGF (basic), VEGFR-1/Flt-1, ICAM-1, IFN-γ, IL-1α, IL-1β, IL-10, IL-12/IL-23p40, IL-13, IL-15, IL-16, IL-17A, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, PlGF, SAA, TARC, Tie-2, TNF-α, TNF-β, VCAM-1, VEGF-A, VEGF-C, VEGF-D, FGF (basic)
Human  | Multiplex
V-PLEX Plus NHP Cytokine 24-Plex Kit
Eotaxin-3, GM-CSF, IFN-γ, IL-1β, IL-10, IL-12/IL-23p40, IL-15, IL-16, IL-17A, IL-2, IL-5, IL-6, IL-7, IL-8, IL-8 (HA), IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, TARC, TNF-β, VEGF-A
Non-human primate  | Multiplex
V-PLEX NHP Cytokine 24-Plex Kit
Eotaxin-3, GM-CSF, IFN-γ, IL-1β, IL-10, IL-12/IL-23p40, IL-15, IL-16, IL-17A, IL-2, IL-5, IL-6, IL-7, IL-8, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, TARC, TNF-β, VEGF-A, IL-8 (HA)
Non-human primate  | Multiplex
V-PLEX NHP IL-8 Kit
IL-8
Non-human primate  | Singleplex
V-PLEX NHP IL-6 Kit
IL-6
Non-human primate  | Singleplex
V-PLEX Plus Neuroinflammation Panel 1 Human Kit
CRP, Eotaxin, Eotaxin-3, VEGFR-1/Flt-1, ICAM-1, IFN-γ, IL-1α, IL-1β, IL-10, IL-12/IL-23p40, IL-13, IL-15, IL-16, IL-17A, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, PlGF, SAA, TARC, Tie-2, TNF-α, TNF-β, VCAM-1, VEGF-A, VEGF-C, VEGF-D, FGF (basic)
Human  | Multiplex
Human Osteopontin Kit
Osteopontin
Human  | Singleplex
Human Osteonectin Kit
Osteonectin
Human  | Singleplex
Human Osteocalcin Kit
Osteocalcin
Human  | Singleplex
Human Bone Panel II Kit
Osteocalcin, Osteonectin, Osteopontin
Human  | Multiplex
V-PLEX Proinflammatory Panel 1 Human Kit
IFN-γ, IL-10, IL-12p70, IL-13, IL-1β, IL-2, IL-4, IL-6, IL-8, TNF-α
Human  | Multiplex
V-PLEX Plus Human IL-8 Kit
IL-8
Human  | Singleplex
V-PLEX Plus Human IL-6 Kit
IL-6
Human  | Singleplex
V-PLEX Plus Proinflammatory Panel 1 Human Kit
IL-10, IL-13, IL-1β, IL-2, IL-4, IL-6, IL-8, TNF-α, IFN-γ, IL-12p70
Human  | Multiplex
V-PLEX Plus Mouse IL-6 Kit
IL-6
Mouse  | Singleplex
V-PLEX Plus Proinflammatory Panel1 Mouse Kit
IFN-γ, IL-1β, IL-10, IL-12p70, IL-2, IL-4, IL-5, IL-6, KC/GRO, TNF-α
Mouse  | Multiplex
Proinflammatory Panel 1 Human Control Pack
IL-10, IL-12p70, IL-13, IL-2, IL-4, IL-6, IL-8, IFN-γ, IL-1β, TNF-α
Human
V-PLEX Proinflammatory Panel 1 Mouse Kit
IFN-γ, IL-10, IL-12p70, IL-1β, IL-2, IL-4, IL-5, IL-6, KC/GRO, TNF-α
Mouse  | Multiplex
V-PLEX Plus Chemokine Panel 1 Human Kit
Eotaxin, Eotaxin-3, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, TARC, IL-8 (HA), IL-8
Human  | Multiplex
V-PLEX Chemokine Panel 1 Human Kit
MCP-1, MCP-4, Eotaxin, IP-10, MDC, Eotaxin-3, TARC, MIP-1α, MIP-1β, IL-8 (HA), IL-8
Human  | Multiplex
V-PLEX Rat IL-6 Kit
IL-6
Rat  | Singleplex
V-PLEX Plus Human Proinflam. Panel II (4-Plex)
IL-8, IL-1β, IL-6, TNF-α
Human  | Multiplex
V-PLEX Human Proinflammatory Panel II (4-Plex)
IL-1β, IL-6, IL-8, TNF-α
Human  | Multiplex
V-PLEX Plus Human Proinflam. Panel I (4-Plex)
IFN-γ, IL-1β, IL-6, TNF-α
Human  | Multiplex
V-PLEX Human Proinflammatory Panel I (4-Plex)
IFN-γ, IL-1β, IL-6, TNF-α
Human  | Multiplex
V-PLEX Plus Rat IL-6 Kit
IL-6
Rat  | Singleplex
Chemokine Panel 1 Human Control Pack
Eotaxin, Eotaxin-3, IL-8, IP-10, MCP-1, MCP-4, MDC, TARC
Human
Proinflammatory Panel 1 Rat Control Pack
IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-13, KC/GRO, TNF-α
Rat
Proinflammatory Panel 1 Mouse Control Pack
IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12p70, KC/GRO, TNF-α
Mouse
Mouse IL-6 Antibody
IL-6
Human IL-8 Antibody Bulk Product
IL-8
Human IL-6 Antibody Bulk Product
IL-6
V-PLEX Human IL-8 Kit
IL-8
Human  | Singleplex
V-PLEX Human IL-6 Kit
IL-6
Human  | Singleplex
V-PLEX Mouse IL-6 Kit
IL-6
Mouse  | Singleplex
V-PLEX Plus Human Cytokine 30-Plex Kit
Eotaxin, Eotaxin-3, GM-CSF, IFN-γ, IL-10, IL-12p70, IL-12/IL-23p40, IL-13, IL-15, IL-16, IL-17A, IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, TARC, TNF-α, TNF-β, VEGF-A, IL-8 (HA)
Human  | Multiplex
V-PLEX Human Cytokine 30-Plex Kit
Eotaxin, Eotaxin-3, GM-CSF, IFN-γ, IL-10, IL-12p70, IL-12/IL-23p40, IL-13, IL-15, IL-16, IL-17A, IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, TARC, TNF-α, TNF-β, VEGF-A, IL-8 (HA)
Human  | Multiplex
Rat IL-6 Antibody
IL-6
Human ProInflammatory-4 II Tissue Culture Kit
IL-1β, IL-6, IL-8, TNF-α
Human  | Multiplex
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