IL-1α

Interleukin-1α (IL-1α), also known as IL-1F1 or hematopoietin-1, is a glycosylated protein. IL-1α is produced by activated macrophages and along with IL-1β, it stimulates thymocyte proliferation by inducing IL-2 release and is an endogenous pyrogen. There are multiple receptors of IL-1α. Along with IL-1β, IL-1α binds directly to IL-1 RI, which is then associated with IL-1 R accessory protein (IL-1RAcP) to form a high affinity receptor complex for signal transduction. IL-1 RII has high affinity for IL-1α, but it is a negative regulator of IL-1α activity. IL-1 receptor antagonist (IL-1ra) interacts with IL-1 RI, preventing it from binding IL-1α and IL-1β. IL-1α is associated with a number of disorders such as cerebral amyloid angiopathy-related hemorrhage, periodontal disease, and silicosis.

 

IL-1α Singleplex Products

Our IL-1α immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of IL-1α. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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Related Custom Assays

The following related assays are not in our catalog but may be available as custom orders. Custom orders are typically shipped in 3 to 6 weeks. You may request pricing and availability for the assays below using our Custom Assay Quote Request form.

  • IL-1α - Rat
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