Human interleukin-1α (IL-1α) or IL-1F1, also known as hematopoietin-1, is a glycosylated 30.6 kDa protein. It is produced by activated macrophages and is an endogenous pyrogen. Along with IL-1β it stimulates thymocyte proliferation by inducing IL-2 release. IL-1α has multiple receptors. Along with IL-1β, IL-1α binds directly to IL-1 RI, which is then associated with IL-1 R accessory protein (IL-1RAcP) to form a high-affinity receptor complex for signal transduction. IL-1 RII has high affinity for IL-1α, but it is a negative regulator of IL-1α activity. IL-1 receptor antagonist (IL-1ra) interacts with IL-1 RI preventing it from binding IL-1α and IL-1β. IL-1α is associated with a number of disorders such as cerebral amyloid angiopathy-related hemorrhage, periodontal disease, and silicosis. The Human IL-1α Kit provides assay-specific components for the quantitative determination of endogenous IL-1α in human urine, serum, plasma, and cell culture supernatants.
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Specifications
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Kit Contents
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References
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Documentation
Application(s)
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Cytokines & Chemokines
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Immunology/Inflammation
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Analyte(s)
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IL-1α
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Species
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Human
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Instrument
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MESO QuickPlex SQ 120
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SECTOR Imager 2400
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SECTOR Imager 6000
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MESO SECTOR S 600
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Plate Type
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96-well
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Capture Antibody
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Mouse Monoclonal
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Detection Antibody
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Goat Polyclonal
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LLOD (Sensitivity)
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0.09 pg/mL
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Dynamic Range
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0.09–278 pg/mL
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Sample Type
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Serum, Plasma, Urine, Cell Culture Supernatant
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Recombinant standards
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Expressed in E. coli
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Storage Statement(s)
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Please refer to the product insert for the storage conditions of individual kit components.
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Storage Condition
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Multi-Component
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Product Description
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Storage
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Quantity per Kit
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Cytokine Panel 1 (human) Control 1
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2-8°C
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1 vial
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Cytokine Panel 1 (human) Control 2
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2-8°C
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1 vial
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Cytokine Panel 1 (human) Control 3
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2-8°C
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1 vial
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2-8°C
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1 vial (1 vial)
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2-8°C
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1 vial (75 μL)
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Human IL-1α Plate
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2-8°C
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1 each (1 each)
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Diluent Assembly 3 (includes Diluent 3 - 5 mL, and Diluent 43 - 10 mL)
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≤-10°C
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1 each
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RT
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1 each (100 mL)
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RT
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1 each (50 mL)
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Product Description
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Storage
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Quantity per Kit
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Cytokine Panel 1 (human) Control 1
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2-8°C
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5 vial
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Cytokine Panel 1 (human) Control 2
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2-8°C
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5 vial
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Cytokine Panel 1 (human) Control 3
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2-8°C
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5 vial
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2-8°C
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5 vial (1 vial)
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2-8°C
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1 vial (375 μL)
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Human IL-1α Plate
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2-8°C
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5 each (1 each)
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Diluent Assembly 4 (includes Diluent 3 - 25 mL, and Diluent 43 - 50 mL)
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≤-10°C
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1 each
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RT
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1 each (100 mL)
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RT
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1 each (50 mL)
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Product Description
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Storage
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Quantity per Kit
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Cytokine Panel 1 (human) Control 1
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2-8°C
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25 vial
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Cytokine Panel 1 (human) Control 2
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2-8°C
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25 vial
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Cytokine Panel 1 (human) Control 3
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2-8°C
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25 vial
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2-8°C
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25 vial (1 vial)
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2-8°C
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5 vial (375 μL)
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Human IL-1α Plate
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2-8°C
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25 each (1 each)
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Diluent Assembly 4 (includes Diluent 3 - 25 mL, and Diluent 43 - 50 mL)
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≤-10°C
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5 each
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RT
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5 each (100 mL)
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RT
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5 each (50 mL)
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Title
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Journal
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Year
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Reliability of self-sampling for accurate assessment of respiratory virus viral and immunologic kinetics
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Protection Against Lethal Multidrug-Resistant Bacterial Infections Using Macrophage Cell Therapy
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Stratum Corneum Tape Stripping: Monitoring of Inflammatory Mediators in Atopic Dermatitis Patients Using Topical Therapy.
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Product Inserts
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Product Highlights
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Certificate of analysis
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View More
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SDS
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