U-PLEX Human IL-1α Assay


MSD offers a range of individual assays utilizing U-PLEX Antibody Sets that provide a rapid and convenient method for measuring biomarkers in complex matrices. The individual assays are offered on MSD GOLD Small Spot Streptavidin Plates and use the same antibody sets and diluents as the U-PLEX multiplex assays. This allows for efficient transfer between the individual assay and a higher throughput multiplex configuration. Typical of assays developed on the MSD platform, the individual assays have high sensitivity, excellent precision, provide up to five-logs of linear dynamic range, and require minimal sample volume. Human interleukin-1α (IL-1α) or IL-1F1, also known as hematopoietin-1, is a glycosylated 30.6 kDa protein. It is produced by activated macrophages and is an endogenous pyrogen. Along with IL-1β it stimulates thymocyte proliferation by inducing IL-2 release. IL-1α has multiple receptors. Along with IL-1β, IL-1α binds directly to IL-1 RI, which is then associated with IL-1 R accessory protein (IL-1RAcP) to form a high affinity receptor complex for signal transduction. IL-1 RII has high affinity for IL-1α, but it is a negative regulator of IL-1α activity. IL-1 receptor antagonist (IL-1ra) interacts with IL-1 RI preventing it from binding IL-1α and IL-1β. IL-1α is associated with a number of disorders such as cerebral amyloid angiopathy-related hemorrhage, periodontal disease, and silicosis. The U-PLEX Human IL-1α Assay provides the components for the quantitative determination of both natural and recombinant human IL-1α in serum, plasma, and cell culture supernatants.

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1 plate
5 plates
25 plates
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