V-PLEX Plus Human CRP Kit


C-reactive protein (CRP) is a 23 kDa, acute phase protein and a critical marker of acute inflammation. It is produced mainly by the liver in response to pro-inflammatory cytokines and lipopolysaccharides (LPS). Upon infection, inflammation, or tissue damage, the level of CRP in human serum can increase >1,000-fold within 6 to 48 hours and return to basal levels (<1 Μg/mL) very quickly, making this protein a key marker for innate host immune responses. In contrast to humans, CRP in mice is expressed at a very low level and is not an acute-phase reactant.9 Human CRP shares 71% and 64% sequence homology with mouse and rat, respectively. CRP has been used as a predictive biomarker for several pathological conditions, including cardiovascular disease, type 2 diabetes, and stroke. CRP binds phosphocholine in the membranes of injured cells as well as nuclear components of necrotic and apoptotic cells that initiate the C1q-complement cascade and immune cell phagocytotic responses for clearance of damaged and apoptotic cells. The Human CRP Kit provides assay-specific components for the quantitative determination of CRP in human serum, plasma, cell culture supernatants, cerebral spinal fluid, and urine.

  • Specifications
  • Kit Contents
  • References
  • Documentation
Order Details
Catalog No
Price in USD
1 plate
5 plates
25 plates
Customer Service/Orders

Scientific/Technical Support

Instrument Support

Company Headquarters