V-PLEX Human CRP Kit

C-reactive protein (CRP) is a 23 kDa, acute phase protein and a critical marker of acute inflammation. It is produced mainly by the liver in response to pro-inflammatory cytokines and lipopolysaccharides (LPS). Upon infection, inflammation, or tissue damage, the level of CRP in human serum can increase >1,000-fold within 6 to 48 hours and return to basal levels (<1 Μg/mL) very quickly, making this protein a key marker for innate host immune responses. In contrast to humans, CRP in mice is expressed at a very low level and is not an acute-phase reactant.9 Human CRP shares 71% and 64% sequence homology with mouse and rat, respectively. CRP has been used as a predictive biomarker for several pathological conditions, including cardiovascular disease, type 2 diabetes, and stroke. CRP binds phosphocholine in the membranes of injured cells as well as nuclear components of necrotic and apoptotic cells that initiate the C1q-complement cascade and immune cell phagocytotic responses for clearance of damaged and apoptotic cells. The Human CRP Kit provides assay-specific components for the quantitative determination of CRP in human serum, plasma, cell culture supernatants, cerebral spinal fluid, and urine.

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Order Details
Catalog No
Size
Price in USD
Qty
K151STD-1
1 plate
$530.00
K151STD-2
5 plates
$2,253.00
K151STD-4
25 plates
$9,938.00
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