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A validated assay to measure soluble IL-7 receptor shows minimal impact of IL-7 treatment.
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Acute exposure of mice to high-dose ultrafine carbon black decreases susceptibility to pneumococcal pneumonia.
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An open-label, single-dose bioavailability study of the pharmacokinetics of CAT-354 after subcutaneous and intravenous administration in healthy males.
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Analysis of complex biomarkers for human immune-mediated disorders based on cytokine responsiveness of peripheral blood cells.
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Androgen Receptor-Dependent and Independent Atheroprotection by Testosterone in Male Mice.
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Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization.
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Application of Dolichos biflorus in immunoassay detection of kidney collecting duct biomarkers.
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Applications of a planar electrochemiluminescence platform to support regulated studies of macromolecules: Benefits and limitations in assay range.
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Aß40 Oligomers Identified as a Potential Biomarker for the Diagnosis of Alzheimer's Disease.
Gao, C.M., Yam, A.Y., Wang, X., Magdangal, E., Salisbury, C., Peretz, D., Zuckermann, R.N., Connolly, M.D., Hansson, O., Minthon, L., Zetterberg, H., Blennow, K., Fedynyshyn, J.P. Allauzen, S. | PLoS ONE | 2010 | View |
Assessing agonistic potential of a candidate therapeutic anti-IL21R antibody.
Guo, Y., Hill, A.A., Ramsey, R.C., Immermann, F.W., Corcoran, C., Young, D., Lavallie, E.R., Ryan, M., Bouchard, T., Pfeifer, R., Warner, G., Bologna, M., Bloom, L., O'Toole, M. | J Transl Med. | 2010 | View |
Assessment of DBS technology for the detection of therapeutic antibodies.
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Association between synovial fluid levels of aggrecan ARGS fragments and radiographic progression in knee osteoarthritis.
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AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth.
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B7-H3 Augments the Inflammatory Response and Is Associated with Human Sepsis.
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BACE1 gene variants do not influence BACE1 activity, levels of APP or Aß isoforms in CSF in Alzheimer's disease.
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Beta-amyloid precursor protein mutants respond to gamma-secretase modulators.
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Binding Rate Screen - A high-throughput assay in soluble lysate for prioritizing protein expression constructs.
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Biochemical, cellular, and anti-inflammatory properties of a potent, selective, orally bioavailable benzamide inhibitor of Rho kinase activity.
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Biomarkers as Predictors of Response to Treatment with Motesanib in Patients with Progressive Advanced Thyroid Cancer.
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Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity.
Putcha, P., Danzer, K.M., Kranich, L.R., Scott, A., Silinski, M., Mabbett, S., Hicks, C.D., Veal, J.M., Steed, P.M., Hyman, B.T., McLean, P.J. | J Pharmacol Exp Ther. | 2010 | View |
Cactin Targets the MHC Class III Protein I{kappa}B-like (I{kappa}BL) and Inhibits NF-{kappa}B and Interferon-regulatory Factor Signaling Pathways.
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Capillary pressure may predict preclinical changes in the eye.
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Carbamylated erythropoietin increases frataxin independent from the erythropoietin receptor.
Sturm, B., Helminger, M., Steinkellner, H., Heidari, M.M., Goldenberg, H., Scheiber-Mojdehkar, B. | Eur J Clin Invest. | 2010 | View |
Caveolin-1 modifies the immunity to Pseudomonas aeruginosa.
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CD8+ T cell activation predominate early immune responses to hypercholesterolemia in Apoe-/- mice.
Kolbus, D., Ramos, O.H., Berg, K.E., Persson, J., Wigren, M., Bjorkbacka, H., Fredrikson, G.N., Nilsson, J. | BMC Immunology. | 2010 | View |
Cerebrospinal fluid inflammatory cytokines and biomarkers of injury severity in acute human spinal cord injury.
Kwon, B.K., Stammers, A.M., Belanger, L.M., Bernardo, A., Chan, D., Bishop, C.M., Slobogean, G.P., Zhang, H., Umedaly, H., Giffin, M., Street, J., Boyd, M.C., Paquette, S.J., Fisher, C.G., Dvorak, M.F. | J Neurotrauma. | 2010 | View |
Characterizations and validations of novel antibodies toward translational research.
Williams, R., Chung, J.Y., Ylaya, K., Whiteley, G., Hewitt, S.M. | Proteomics. | 2010 | View |
Cholinergic augmentation of insulin release requires ankyrin-B.
Healy, J.A., Nilsson, K.R., Hohmeier, H.E., Berglund, J., Davis, J., Hoffman, J., Kohler, M., Li, .LS., Berggren, P.O., Newgard, C.B., Bennett, V. | Sci Signal. | 2010 | View |
Chronic treatment with epoxyeicosatrienoic acids modulates insulin signaling and prevents insulin resistance in hepatocytes.
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Comparative profile of commercially available urinary biomarkers in preclinical drug-induced kidney injury and recovery in rats.
Rouse, R.L., Zhang, J., Stewart, S.R., Rosenzweig, B.A., Espandiari, P., Sadrieh, N.K. | Kidney Int. | 2010 | View |
Comparing levels of biochemical markers in CSF from cannulated and non-cannulated rats.
Cassar, S.C., Tovcimak, A.E., Rustay, N.R., Ellis, T.A., Hooker, B.A., Witte, D.G., Li, J., Buck, W.R., Scharf, D., Muller, U., Jeromin, A., Wang, K.K., Waring, J.F. | J Neurosci Methods. | 2010 | View |
Comparison of conventional ELISA with electrochemiluminescence technology for detection of amyloid-ß in plasma.
Oh, E.S., Mielke, M.M., Rosenberg, P.B., Jain, A., Fedarko, N.S., Lyketsos, C.G., Mehta, P.D. | J Alzheimers Dis. | 2010 | View |
Comparison of Multiplex Immunoassay Platforms.
Fu, Q., Zhu, J., Van Eyk, J.E. | Clinical Chemistry. | 2010 | View |
Comparison of Pharmacological Modulation of APP Metabolism in Primary Chicken Telencephalic Neurons and in a Human Neuroglioma Cell Line.
Czvitkovich, S., Duller, S., Mathiesen, E., Lorenzoni, K., Imbimbo, B.P., Hutter-Paier, B., Windisch, M., Wronski, R. | J Mol Neurosci. | 2010 | View |
Confounding Factors Influencing Amyloid Beta Concentration in Cerebrospinal Fluid.
Bjerke, M., Portelius, E., Minthon, L., Wallin, A., Anckarsater, H., Anckarsater, R., Andreasen, N., Zetterberg, H., Andreasson, U., Blennow, K. | International Journal of Alzheimer's Disease. | 2010 | View |
Converging molecular pathways in human neural development and degeneration.
Mattsson, N., Sävman, K., Osterlundh, G., Blennow, K., Zetterberg, H. | Neurosci Res. | 2010 | View |
Converging pathways of chromogranin and amyloid metabolism in the brain.
Mattsson, N., Johansson, P., Hansson, O., Wallin, A., Johansson, J.O., Andreasson, U., Andersen, O., Haghighi, S., Olsson, M., Stridsberg, M., Svensson, J., Blennow, K., Zetterberg, H. | J Alzheimers Dis. | 2010 | View |
Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis.
Mnich, S.J., Blanner, P.M., Hu, G., Shaffer, A.F., Happa, F.A., O'Neil, S., Ukairo, O., Weiss, D., Welsh, E., Storer, C., Mbalaviele, G., Ichijo, H., Monahan, J.B., Hardy, M.M., Eda, H. | Int Immunopharmacol. | 2010 | View |
Crosstalk of the EphA2 receptor with a serine/threonine phosphatase suppresses the Akt-mTORC1 pathway in cancer cells.
Yang, N.Y., Fernandez, C., Richter, M., Xiao, Z., Valencia, F., Tice, D.A., Pasquale, E.B. | Cell Signal. | 2010 | View |
CSF amyloid {beta}38 as a novel diagnostic marker for dementia with Lewy bodies.
Mulugeta, E., Londos, E., Ballard, C., Alves, G., Zetterberg, H., Blennow, K., Skogseth, R., Minthon, L., Aarsland, D. | J Neurol Neurosurg Psychiatry. | 2010 | View |
CSF amyloid-{beta} and tau proteins, and cognitive performance, in early and untreated Parkinson's Disease: the Norwegian ParkWest study.
Alves, G., Bronnick, K., Aarsland, D., Blennow, K., Zetterberg, H., Ballard, C., Kurz, M.W., Andreasson, U., Tysnes, O.B., Larsen, J.P., Mulugeta, E. | J Neurol Neurosurg Psychiatry. | 2010 | View |
Cytokine levels in the blood may distinguish suicide attempters from depressed patients.
Janelidze, S., Mattei, D., Westrin, S., Träskman-Bendz, L., Brundin, L. | Brain Behavior and Immunity | 2010 | View |
Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice.
Sugimoto, H., Okada, K., Shoda, J., Warabi, E., Ishige, K., Ueda, T., Taguchi, K., Yanagawa, T., Nakahara, A., Hyodo, I., Ishii, T., Yamamoto, M. | Am J Physiol Gastrointest Liver Physiol. | 2010 | View |
Detection of neutralizing interleukin-17 antibodies in autoimmune polyendocrinopathy syndrome-1 (APS-1) patients using a novel non-cell based electrochemiluminescence assay.
Cludts, I., Meager, A., Thorpe, R., Wadhwa, M. | Cytokine | 2010 | View |
Differences in effects on myocardium and mitochondria by angiogenic inhibitors suggest separate mechanisms of cardiotoxicity.
French, K.J., Coatney, R.W., Renninger, J.P., Hu, C.X., Gales, T.L., Zhao, S., Storck, L.M., Davis, C.B., McSurdy-Freed, J., Chen, E., Frazier, K.S. | Toxicol Pathol. | 2010 | View |
Differential IL-17 production and mannan recognition contribute to fungal pathogenicity and commensalism.
Rizzetto, L., Kuka, M., De Filippo, C., Cambi, A., Netea, M.G., Beltrame, L., Napolitani, G., Torcia, M.G., D'Oro, U., Cavalieri, D. | J Immunol Methods | 2010 | View |
Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors for the treatment of cancer.
Sutherlin, D.P., Sampath, D., Berry, M., Castanedo, G., Chang, Z., Chuckowree, I., Dotson, J., Folkes, A., Friedman, L., Goldsmith, R., Heffron, T., Lee, L., Lesnick, J., Lewis, C., Mathieu, S., Nonomiya, J., Olivero, A., Pang, J., Prior, W.W., Salphati, L., Sideris, S., Tian, Q., Tsui, V., Wan, N.C., Wang, S., Wiesmann, C., Wong, S., Zhu, B.Y. | J Med Chem. | 2010 | View |