Converging molecular pathways in human neural development and degeneration.

Mattsson, N., Sävman, K., Osterlundh, G., Blennow, K., Zetterberg, H.
Journal   Neurosci Res.
Species  
Analytes Measured   APP
Matrix Tested   Cerebrospinal fluid (CSF)
Year   2010
Volume   66
Page Numbers   330-2
Application   Alzheimers
Abstract
Animal studies suggest that phosphorylation of microtubule-associated protein tau is a physiological way of destabilizing axons in the developing brain, promoting synaptic plasticity, while in the adult human brain tau phosphorylation is a specific sign of Alzheimer's disease. We here show, for the first time, that newborn human infants have extremely high levels of phosphorylated tau in their cerebrospinal fluid, and that these levels decrease during the first years of life. Tau phosphorylation in Alzheimer's disease may be a physiological response to Alzheimer-associated synaptotoxicity.

View Publications

Related Products

sAPPα Kit
APP | Human
Multiplex
sAPPβ Kit
APP | Human
Singleplex
sw sAPPβ Kit
APP | Human
Singleplex
sAPPα/sAPPβ Kit
APP | Human
Multiplex
Browse Our Products

By Analytes
By Applications
Search
Customer Service/Orders


Scientific/Technical Support


Instrument Support


Company Headquarters