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Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model. Burkholder, T.P., Clayton, J.R., Rempala, M.E., Henry, J.R., Knobeloch, J.M., Mendel, D., McLean, J.A., Hao, Y., Barda, D.A., Considine, E.L., Uhlik, M.T., Chen, Y., Ma, L., Bloem, L.J., Akunda, J.K., McCann, D.J., Sanchez-Felix, M., Clawson, D.K., Lahn, M.M., Starling, J.J. | Invest New Drugs. | 2011 | View |
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Duodenal-jejunal bypass protects GK rats from {beta}-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-1. Speck, M., Cho, Y.M., Asadi, A., Rubino, F., Kieffer, T.J. | Am J Physiol Endocrinol Metab. | 2011 | View |
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Efficacy of Ganitumab (AMG 479), Alone and in Combination With Rapamycin, in Ewing's and Osteogenic Sarcoma Models. Beltran, P.J., Chung, Y.A., Moody, G., Mitchell, P., Cajulis, E., Vonderfecht, S., Kendall, R., Radinsky, R., Calzone, F.J. | Pharmacol Exp Ther. | 2011 | View |
Endothelial dysfunction and low-grade inflammation are associated with greater arterial stiffness over a 6-year period. van Bussel, B.C., Schouten, F., Henry, R.M., Schalkwijk, C.G., de Boer, M.R., Ferreira, I., Smulders, Y.M., Twisk, J.W., Stehouwer, C.D. | Hypertension. | 2011 | View |
Enhanced humoral and cell-mediated immune responses after immunization with trivalent influenza vaccine adjuvanted with cationic liposomes. Rosenkrands, I., Vingsbo-Lundberg, C., Bundgaard, T.J., Lindenstrøm, T., Enouf, V., van der Werf, S., Andersen, P., Agger, E.M. | Vaccine. | 2011 | View |
Enhanced peripheral toll-like receptor responses in psychosis: further evidence of a pro-inflammatory phenotype. McKernan, D.P., Dennison, U., Gaszner, G., Cryan, J.F., Dinan, T.G. | Translational Psychiatry | 2011 | View |
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E-Selectin is Elevated in Cord Blood of South Asian Neonates Compared with Caucasian Neonates. Boon MR, Karamali NS, de Groot CJ, van Steijn L, Kanhai HH, van der Bent C, Berbée JF, Middelkoop B, Rensen PC, Tamsma JT. | J Pediatr. | 2011 | View |
Essential Role for Protein Kinase C{zeta} in Oleic Acid-Induced Glucagon-Like Peptide-1 Secretion in Vivo in the Rat. Iakoubov, R., Ahmed, A., Lauffer, L.M., Bazinet, R.P., Brubaker, P.L. | Endocrinology | 2011 | View |
Evaluation of KRAS mutations, angiogenic biomarkers and DCE-MRI in patients with advanced non-small cell lung cancer receiving sorafenib. Kelly, R.J., Rajan, A., Force, J., Keen, C., Cao, L., Yu, Y., Choyke, P.L., Turkbey, B., Raffeld, M., Xi, L., Steinberg, S.M., Wright, J.J., Lopez-Chavez, A., Kummar, S., Guttierrez, M., Giaccone, G. | Clin Cancer Res. | 2011 | View |
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Exchanging Saturated Fatty Acids for (n-6) Polyunsaturated Fatty Acids in a Mixed Meal May Decrease Postprandial Lipemia and Markers of Inflammation and Endothelial Activity in Overweight Men. Masson, C.J., Mensink, R.P. | J Nutr. | 2011 | View |
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Fate of Transgenic DNA from Orally Administered Bt MON810 Maize and Effects on Immune Response and Growth in Pigs. Walsh, M.C., Bouzuianu, S.G., Gardiner, G.E., Rea, M.C., Gelencser, E., Janosi, A., Epstein, M.M., Ross, R.P., Lawlor, P.G. | PLoS One. | 2011 | View |
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Functionalized Scaffold-mediated Interleukin 10 Gene Delivery Significantly Improves Survival Rates of Stem Cells In Vivo. Holladay, C., Power, K., Sefton, M., O'Brien, T., Gallagher, W.M., Pandit, A. | Mol Ther. | 2011 | View |
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GPR119 agonists mediate GLP-1 secretion from mouse enteroendocrine cells through glucose-independent pathways. Lan, H., Lin, H.V., Wang, C.F., Wright, M.J., Xu, S., Kang, L., Juhl, K., Hedrick, J.A., Kowalski, T.J. | Br J Pharmacol. | 2011 | View |
Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2. Jornayvaz, F.R., Birkenfeld, A.L., Jurczak, M.J., Kanda, S., Guigni, B.A., Jiang, D.C., Zhang, D., Lee, H.Y., Samuel, V.T., Shulman, G.I. | Proc Natl Acad Sci USA. | 2011 | View |
High plasma interleukin-18 levels mark the acute phase of hepatitis C virus infection. Chattergoon, M.A., Levine, J.S., Latanich, R., Osburn, W.O., Thomas, D.L., Cox, A.L. | J Infect Dis. | 2011 | View |
High-dose zidovudine plus valganciclovir for Kaposi sarcoma herpesvirus-associated multicentric Castleman disease: a pilot study of virus-activated cytotoxic therapy. Uldrick, T.S., Polizzotto, M.N., Aleman, K., O'Mahony, D., Wyvill, K.M., Wang, V., Marshall, V., Pittaluga, S., Steinberg, S.M., Tosato, G., Whitby, D., Little, R.F., Yarchoan, R. | Blood | 2011 | View |
Higher Levels of CRP, D-dimer, IL-6, and Hyaluronic Acid Before Initiation of Antiretroviral Therapy (ART) Are Associated With Increased Risk of AIDS or Death. Boulware, D.R., Hullsiek, K.H., Puronen, C.E., Rupert, A., Baker, J.V., French, M.A., Bohjanen, P.R., Novak, R.M., Neaton, J.D., Sereti, I; for the INSIGHT Study Group. | J Infect Dis. | 2011 | View |
High-Throughput Simultaneous Analysis of RNA, Protein, and Lipid Biomarkers in Heterogeneous Tissue Samples. Reiser, V., Smith, R.C., Xue, J., Kurtz, M.M., Liu, R., Legrand, C., He, X., Yu, X., Wong, P., Hinchcliffe, J.S., Tanen, M.R., Lazar, G., Zieba, R., Ichetovkin, M., Chen, Z., O'Neill, E.A., Tanaka, W.K., Marton, M.J., Liao, J., Morris, M., Hailman, E., Tokiwa, G.Y., Plump, A.S. | Clin Chem. | 2011 | View |
Human Keratinocytes' Response to Injury Upregulates CCL20 and Other Genes Linking Innate and Adaptive Immunity. Kennedy-Crispin, M., Billick, E., Mitsui, H., Gulati, N., Fujita, H., Gilleaudeau, P., Sullivan-Whalen, M., Johnson-Huang, L.M., Suárez-Fariñas, M., Krueger, J.G. | J Invest Dermatol. | 2011 | View |
Hypoxia-inducible factor 1{alpha} (HIF-1 {alpha}) and autophagy in polycystic kidney disease (PKD). Belibi, F., Zafar, I., Ravichandran, K., Bauer Segvic, A., Jani, A., Ljubanovic, D.G., Edelstein, C.L. | Am J Physiol Renal Physiol. | 2011 | View |
Identification of SPARC-like Protein as Part of a Biomarker Panel for Alzheimer's Disease in Cerebrospinal Fluid. Vafadar-Isfahani, B., Ball, G., Coveney, C., Lemetre, C., Boocock, D., Minthon, L., Hansson, O., Miles, A.K., Janciauskiene, S.M., Warden, D., Smith, A.D., Wilcock, G., Kalsheker, N., Rees, R., Matharoo-Ball, B., Morgan, K. | J Alzheimers Dis. | 2011 | View |
IL-1alpha/IL-1R1 Expression in Chronic Obstructive Pulmonary Disease and Mechanistic Relevance to Smoke-Induced Neutrophilia in Mice. Botelho FM, Bauer CM, Finch D, Nikota JK, Zavitz CC, Kelly A, Lambert KN, Piper S, Foster ML, Goldring JJ, Wedzicha JA, Bassett J, Bramson J, Iwakura Y, Sleeman M, Kolbeck R, Coyle AJ, Humbles AA, Stämpfli MR. | PLoS One. | 2011 | View |
IL-6-independent association of elevated serum neopterin levels with prevalent frailty in community-dwelling older adult. Leng, S.X., Tian, X., Matteini, A., Li, H., Hughes, J., Jain, A., Walston, J.D., Fedarko, N.S. | Age Ageing. | 2011 | View |
IL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancer. Anglesio, M.S., George, J., Kulbe, H., Friedlander, M., Rischin, D., Lemech, C., Power, J., Coward, J., Cowin, P.A., House, C.M., Chakravarty, P., Gorringe, K.L., Campbell, I.G.; Australian Ovarian Cancer Study Group, Okamoto, A., Birrer, M.J., Huntsman, D.G., de Fazio, A., Kalloger, S.E., Balkwill, F., Gilks, C.B., Bowtell, D.D. | Clin Cancer Res. | 2011 | View |
IL-10 Blocks Phagosome Maturation in Mycobacterium tuberculosis-infected Human Macrophages. O'Leary, S., O'Sullivan, M.P., Keane, J. | Am J Respir Cell Mol Biol. | 2011 | View |
Immediate and long-term effects of addition of exercise to a 16-week very low calorie diet on low-grade inflammation in obese, insulin-dependent type 2 diabetic patients. Snel, M., Diepen, J.A., Stijnen, T., Pijl, H., Romijn, J.A., Edo Meinders, A., Voshol, P., Jazet, I.M. | Food Chem Toxicol. | 2011 | View |
Immune Activation Resulting From NKG2D/Ligand Interaction Promotes Atherosclerosis. Xia, M., Guerra, N., Sukhova, G.K., Yang, K., Miller, C.K., Shi, G.P., Raulet, D.H., Xiong, N. | Circulation. | 2011 | View |
Immune Responses to the Enduring Hypoxic Response Antigen Rv0188 Are Preferentially Detected in Mycobacterium bovis Infected Cattle with Low Pathology. Jones, G.J., Pirson,C., Gideon, H.P., Wilkinson, K.A., Sherman, D.R., Wilkinson, R.J., Hewinson, R.G., Vordermeier, H.M. | PLoS ONE | 2011 | View |
In Vivo and In Vitro Characterization of a First-in-Class Novel Azole Analog That Targets Pregnane X Receptor Activation. Venkatesh, M., Wang, H., Cayer, J., Leroux, M., Salvail, D., Das, B., Wrobel, J.E., Mani, S. | Mol Pharmacol. | 2011 | View |
Increased levels of circulating interleukin 6, interleukin 8, C-reactive protein, and risk of lung cancer. Pine, S.R., Mechanic, L.E., Enewold, L., Chaturvedi, A.K., Katki, H.A., Zheng, Y.L., Bowman, E.D., Engels, E.A., Caporaso, N.E., Harris, C.C. | J Natl Cancer Inst. | 2011 | View |
Infant gut microbiota is protective against cow's milk allergy in mice despite immature ileal T-cell response. Rodriguez, B., Prioult, G., Hacini-Rachinel, F., Moine, D., Bruttin, A., Ngom-Bru, C., Labellie, C., Nicolis, I., Berger, B., Mercenier, A., Butel, M.J., Waligora-Dupriet, A.J. | FEMS Microbiol Ecol. | 2011 | View |
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Inflammatory responses to trivalent influenza virus vaccine among pregnant women. Christian, L.M., Iams, J.D., Porter, K., Glaser, R. | Vaccine. | 2011 | View |
Inflammatory Signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in mice. Stanton, M.C., Chen, S.C., Jackson, J.V., Rojas-Triana, A., Kinsley, D., Cui, L., Fine, J.S., Greenfeder, S., Bober, L.A., Jenh, C.H. | J Inflamm. | 2011 | View |
Inhibition of Apical Sodium-Dependent Bile Acid Transporter (Asbt) as a Novel Treatment for Diabetes. Chen, L., Yao, X., Young, A., McNulty, J., Anderson, D., Liu, Y., Nystrom, C., Croom, D., Ross, S., Collins, J., Rajpal, D., Hamlet, K., Smith, C.D., Gedulin, B.R. | Am J Physiol Endocrinol Metab. | 2011 | View |
Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides. Rayner, K.J., Esau, C.C., Hussain, F.N., McDaniel, A.L., Marshall, S.M., van Gils, J.M., Ray, T.D., Sheedy, F.J., Goedeke, L., Liu, X., Khatsenko, O.G., Kaimal, V., Lees, C.J., Fernandez-Hernando, C., Fisher, E.A., Temel, R.E., Moore, K.J. | Nature. | 2011 | View |