Urinary biomarkers track the progression of nephropathy in hypertensive and obese rats.

Zhang Q, Davis KJ, Hoffmann D, Vaidya VS, Brown RP, Goering PL.
Journal   Biomark Med.
Species  
Analytes Measured   Albumin , Clusterin , GSTYb1 , KIM-1 , Osteopontin , RPA-1
Matrix Tested   Urine
Year   2014
Volume   8
Page Numbers   85-94
Application   Toxicology
Abstract
Aims:To determine whether urinary biomarkers of acute kidney injury can be used to monitor the progression of chronic kidney injury in a rat model of hypertension and obesity.

Materials & methods: A suite of novel urinary biomarkers were used to track the progression of kidney damage in SHROB and SHR-lean rats.

Results: Urinary albumin, NAG, clusterin, osteopontin, RPA-1 and fibrinogen levels were significantly elevated over time and were closely associated with the severity of histopathologically determined nephropathy in both SHROB and SHR-lean rats.

Conclusion: Urinary biomarkers, such as albumin, fibrinogen, NAG, clusterin, RPA-1 and osteopontin, may serve as useful tools to track the progression of chronic kidney disease associated with hypertension and obesity.

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