YKL-40

YKL-40 (also known as human cartilage glycoprotein 39; HC-gp39) is an inflammatory glycoprotein involved in the activation of the innate immune system and extracellular matrix remodeling. YKL-40 is secreted by macrophages, neutrophils, chondrocytes, vascular smooth muscle, and hepatic stellate cells. Elevated serum YKL-levels are associated with the presence and extent of coronary artery disease (CAD) and even higher YKL-40 levels have been documented in patients with myocardial infarction and both type 1 and type 2 diabetes. Enhanced expression of YKL-40 is observed in macrophages and smooth muscle cells in atherosclerotic plaques. In endothelial dysfunction, elevated YKL-40 levels seem to be involved in cell migration, reorganization, and tissue remodeling in response to endothelial damage. Therefore, YKL-40 may play a role in multiple pathogenic processes related to inflammation, extracellular tissue remodeling, fibrosis, and the metastatic and angiogenic invasiveness of many solid tumors.

 

YKL-40 Singleplex Products

Our YKL-40 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of YKL-40. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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YKL-40 Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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