U-PLEX Human YKL-40 Assay


U-PLEX Human YKL-40 Assay Overview
The U-PLEX Human YKL-40 Assay maximizes your flexibility to design an experiment that measures YKL-40 alone or multiplexed with other MSD U-PLEX assays, your own antibody pairs, or a combination of both. This assay accurately quantitates native and recombinant human YKL-40 in multiple sample types. To learn more about the advantages of U-PLEX assays click here.

U-PLEX Human YKL-40 Assay Features
  • Measures human YKL-40 in serum, plasma, and cell culture supernatants
  • Dynamic range: 0.39 pg/mL – 5,000 pg/mL
  • LLOD: 0.39 pg/mL

Typical Data
Calibration curve accuracy and precision for the U-PLEX Human YKL-40 assay were assessed and representative data are presented below.

Figure 1. U-PLEX Human YKL-40 Calibration Curve
Human YKL-40 Calibrator Curve
Figure 2. U-PLEX Human YKL-40 Data
Human YKL-40 Calibrator Curve Data
YKL-40 Analyte

Description - YKL-40 (cartilage glycoprotein 39; HC-gp39) is an inflammatory glycoprotein involved in the activation of the innate immune system and extracellular matrix remodeling. YKL-40 is secreted by macrophages, neutrophils, chondrocytes, vascular smooth muscle, and hepatic stellate cells. Elevated serum YKL-levels are associated with the presence and extent of coronary artery disease (CAD) and even higher YKL-40 levels have been documented in patients with myocardial infarction and both type 1 and type 2 diabetes. Enhanced expression of YKL-40 is observed in macrophages and smooth muscle cells in atherosclerotic plaques. In endothelial dysfunction, elevated YKL-40 levels seem to be involved in cell migration, reorganization, and tissue remodeling in response to endothelial damage. Therefore, YKL-40 may play a role in multiple pathogenic processes related to inflammation, extracellular tissue remodeling, fibrosis, and the metastatic and angiogenic invasiveness of many solid tumors.

Disease Focus/Application Area - Autoimmune disorders including rheumatoid arthritis.

Note - In-house data indicate that a large sample dilution is required to generate optimal results. Refer to the datasheet for additional information.

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