Tumor necrosis factor-beta (TNF-β), also known as lymphotoxin-α, is a protein and member of the cytokine TNF family, a group of cytokines known to contribute to apoptosis. TNF-β is both structurally and functionally similar to TNF-α with 35% protein sequence homology, and both bind to the same cell surface receptors (TNF-RI and TNF-RII). It is produced by TH1 type T-cells after antigenic or mitogenic stimulation and is cytotoxic for a range of tumor cells. Genetic polymorphism within the regulatory regions of TNF-α and TNF-β (specifically 252 A to G in TNF-β) are linked to various malignancies. TNF-β is a mediator of inflammatory, immunostimulatory, and antiviral responses. It may also be involved in the proper development of secondary lymphoid organs such as lymph nodes and Peyer’s patches. TNF-β has also been shown to contribute to the susceptibility of several autoimmune diseases, including graft-versus-host and rheumatoid arthritis, as well as diabetes and other disorders.


TNF-β Singleplex Products

Our TNF-β immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of TNF-β. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.


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