MSD offers a range of individual assays utilizing U-PLEX Antibody Sets that provide a rapid and convenient method for measuring biomarkers in complex matrices. The individual assays are offered on MSD GOLD Small Spot Streptavidin Plates and use the same antibody sets and diluents as the U-PLEX multiplex assays. This allows for efficient transfer between the individual assay and a higher throughput multiplex configuration. Typical of assays developed on the MSD platform, the individual assays have high sensitivity, excellent precision, provide up to five-logs of linear dynamic range, and require minimal sample volume. Tumor necrosis factor beta (TNF-β), also known as lymphotoxin-alpha (LT-alpha) and TNFSF1, is a glycosylated 22.3 kDa protein. It is produced by lymphocytes, and in its homotrimeric form, it binds to TNFR1, TNFRII, and TNFRSF14. In its heterotrimeric form with lymphotoxin-beta, it binds to TNFRSF3. It is cytotoxic for a wide range of tumor cells. A polymorphism of the TNF-β gene is identified as a major risk factor for early-onset leprosy. The U-PLEX NHP TNF-β Assay provides the components for the quantitative determination of both natural and recombinant TNF-β in Cynomolgus monkey and Rhesus monkey serum, plasma, and cell culture supernatants.

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