V-PLEX Human TNF-β Kit


Human tumor necrosis factor beta (TNF-β), also known as lymphotoxin-alpha (LT-alpha) and TNFSF1, is a glycosylated 22.3 kDa protein. It is produced by lymphocytes, and in its homotrimeric form, it binds to TNFR1, TNFRII, and TNFRSF14. In its heterotrimeric form with lymphotoxin-beta, it binds to TNFRSF3. It is cytotoxic for a wide range of tumor cells. A polymorphism of the TNF-β gene is identified as a major risk factor for early-onset leprosy. The Human TNF-β Kit provides assay-specific components for the quantitative determination of endogenous TNF-β in human urine, serum, plasma, and cell culture supernatants.

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