MIP-1β

Macrophage inflammatory protein 1 beta (MIP-1β/CCL4), also known as lymphocyte activation gene 1 protein (LAG-1), is a member of the chemokine family of proteins. MIP-1β is produced by different cell types, particularly macrophages, lymphocytes, and dendritic cells in response to a variety of external stimuli. MIP-1β tightly binds to CCR5 receptor as part of its natural function in the immune response. CCR5 is shared between MIP-1β, MIP-1α, RANTES, and CCL3L1. MIP-1β is one of the major HIV suppressive factors produced by CD8+ T cells. Studies have shown the recombinant form of MIP-1β inhibits different strains of HIV-1, HIV-2, and SIV in a dose-dependent manner. MIP-1β down-modulates the expression of CCR5 and thus inhibits the CCR5-mediated entry of HIV-1 in T-cells. In addition to its involvement in HIV infection, MIP-1β plays a role in large granular lymphocyte leukemia and organ transplant rejection.

 

MIP-1β Singleplex Products

Our MIP-1β immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of MIP-1β. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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MIP-1β Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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