IL-8

Interleukin-8 (IL-8), also known as C-X-C motif chemokine 8 (CXCL8), is a proinflammatory chemokine that binds to CXCR1 and CXCR2 receptors. IL-8 is expressed by several cell types as a response to inflammation. IL-8 attracts neutrophils, basophils, and T-cells, but not monocytes. IL-8 is also involved in neutrophil activation. There are several N-terminal processed forms of IL-8 with varying activity resulting from proteolytic cleavage upon secretion. IL-8 acts as a potent pro-angiogenic factor by enhancing endothelial cell proliferation and survival in cells expressing CXCR1 and CXCR2. Within colon cancer cell lines, IL-8 has been observed to induce angiogenesis in HIF-1 deficient cells. IL-8 is also associated with numerous disorders such as ovarian carcinoma, systematic lupus erythematosus nephritis, and helicobacter pylori-induced duodenal ulcer and gastritis.

 

IL-8 Singleplex Products

Our IL-8 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of IL-8. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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IL-8 Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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