IL-33

Interleukin-33 (IL-33) is a member of the IL-1 cytokine family, and is structurally similar to IL-1β and IL-18. It is synthesized as a 31 kDa precursor protein that undergoes cleavage by caspase-1 to generate an 18 kDa protein. There is approximately 55% similarity in the amino acid sequence between human and mouse IL-33 proteins. IL-33 functions by interacting with a heterodimer receptor that consists of ST2 and IL-1RacP. IL-33 stimulates the production of proinflammatory cytokines as well as TH2 cytokines and chemokines in several immune cell types including mast cells, lymphocytes, basophils, and eosinophils. IL-33 has been shown to reduce the effects of atherosclerosis by the stimulation of TH2 cytokines. IL-33 has been implicated in the pathogenesis of inflammatory conditions such as asthma and atopic dermatitis, and rheumatological diseases, including rheumatoid arthritis, osteoarthritis, and systemic lupus erythematosus (SLE).

 

IL-33 Singleplex Products

Our IL-33 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of IL-33. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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IL-33 Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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