V-PLEX Plus Mouse IL-33 Kit


V-PLEX Plus Mouse IL-33 Kit Overview
The V-PLEX Plus Mouse IL-33 Kit is optimized for long-term and multi-site biomarker studies that require reliable, reproducible results with lot-to-lot consistency. The V-PLEX Plus Mouse IL-33 Kit enables the sensitive detection of native IL-33 in multiple sample types including serum, plasma, urine, cell culture supernatants, and PBMCs. To learn more about the advantages of V-PLEX assays click here.
The V-PLEX Plus Mouse IL-33 assay is also available in a multiplex combination with other related cytokines in the V-PLEX Cytokine Panel 1 (mouse) Kit (catalog # K15245G, K15245D).
All V-PLEX kits come with coated plates, calibrators, labeled detection antibodies, optimized diluents, a comprehensive product insert, and a certificate of analysis. V-PLEX Plus kits also include controls, wash buffer, and plate seals for added quality and convenience.

V-PLEX Plus Mouse IL-33 Assay Features
  • Validated to measure mouse IL-33 in serum, plasma, cell culture supernatants, PBMCs, and urine
  • Dynamic range: 0.364 pg/mL – 1,950 pg/mL
  • LLOQ: 1.85 pg/mL

Typical Data
Calibration curve accuracy and precision for the V-PLEX Plus Mouse IL-33 assay were assessed and representative data are presented below.

Figure 1. V-PLEX Plus Mouse IL-33 Calibration Curve
Mouse IL-33 Calibrator Curve
Figure 2. V-PLEX Plus Mouse IL-33 Data
Mouse IL-33 Calibrator Curve Data
IL-33 Analyte

Description - Mouse interleukin-33 (DVS27) is a member of the IL-1 cytokine family, and is structurally similar to IL-1β and IL-18. It is synthesized as a 31 kDa precursor protein that undergoes cleavage by caspase-1 to generate an 18 kDa protein. IL-33 stimulates the production of proinflammatory cytokines as well as TH2 cytokines and chemokines in several immune cell types including mast cells, lymphocytes, basophils, and eosinophils. IL-33 has been shown to reduce the effects of atherosclerosis by the stimulation of TH2 cytokines.

Disease Focus - Pathogenesis of inflammatory conditions including asthma and atopic dermatitis, and rheumatological diseases, including rheumatoid arthritis and systemic lupus erythematosus (SLE).

Application Area - Inflammation, cytokines, and chemokines

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25 plates
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