Interleukin-22 (IL-22), first described as IL-10-related T cell inducible factor, is part of the IL-10 superfamily notable for its pro inflammatory or anti-inflammatory actions, which are dependent on the context of its expression. It is produced by Th17 cells and NK cells, and especially in epithelial cells like those in the skin, lung, liver, and intestine. IL-22 binds heterodimer IL-22R that is made up of IL-22R1 and IL-10R2. IL-22 concentration in synovial fluid and serum is higher in rheumatoid arthritis patients than in osteoarthritic or normal patients. This is thought to be the result of the induction of RANKL and increased osteoclast production leading to joint inflammation. In contrast, IL-22 plays a protective and anti-inflammatory role in alcohol liver injury with increased levels of IL-22 reflecting reduced markers of oxidative stress, inflammation, and injury in serum. Improved liver health is corroborated through histological examination. In another example of anti-inflammatory properties, IL-22 is upregulated in allergic airway inflammation to attenuate the inflammatory activity of eosinophils and possibly the subsequent production of pro-inflammatory cytokines and chemokines.


IL-22 Singleplex Products

Our IL-22 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of IL-22. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.


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IL-22 Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.


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