V-PLEX Human SAA Kit


Serum amyloid A (SAA) proteins are multifunctional, acute-phase proteins produced by hepatocytes in response to pro-inflammatory cytokines. The human SAA protein is polymorphic, comprising of several related proteins (SAA1 to SAA4). SAA has been linked to functions related to inflammation, pathogen defense, HDL metabolism, and cholesterol transport. It has been implicated in several pathological conditions including atherosclerosis, rheumatoid arthritis, Alzheimer’s disease, and cancer. SAA is secreted as a 12 kDa, non­glycosylated polypeptide, almost exclusively bound to high density lipoproteins (HDL) in plasma; it requires release from HDL complexes in order to become active. SAA circulates at trace levels (1–5 μg/mL) under normal conditions, but levels can increase 1000-fold (500–1000 μg/mL) within 4 to 6 hours after inflammatory stimuli such as infection, tissue injury, or trauma. The Human SAA Kit provides assay-specific components for the quantitative determination of SAA in human serum, plasma, cell culture supernatants, cerebral spinal fluid, and urine.

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