V-PLEX Human VCAM-1 Kit


Vascular cell adhesion molecule 1 (VCAM-1/CD106) is a 100-110 kDa, transmembrane protein expressed by activated endothelial cells, neurons, smooth muscle cells, fibroblasts, and macrophages. VCAM­-1 expression is induced by IL­-1Β, IL­4, TNF-­Α, and IFN­-Γ. It binds to leukocyte integrins VLA­4 and Α4Β7, mediating attachment of leukocytes to the vascular endothelium and extravasation of immune cells from vessels to site of inflammation. This binding may promote monocyte adhesion and accumulations on the vessel wall at sites that are prone to developing atherosclerotic lesions. VCAM-­1 is also present in plasma and cerebral spinal fluid at variable levels which may lead to a variety of pathological conditions. Other roles proposed for VCAM-1 include the regulation of osteoclastogenesis via a cell-to-cell contact mechanism and the induction of sickle cell adherence to vascular endothelial cells during hypoxemia. The Human VCAM-1 Kit provides assay-specific components for the quantitative determination of VCAM-1 in human serum, plasma, cell culture supernatants, cerebral spinal fluid, and urine.

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25 plates
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