R-PLEX Human Troponin T (cardiac) Antibody Set Overview
The R-PLEX Human Troponin T (cardiac) Antibody Set includes a matched capture and detection antibody pair and calibrator for the quick and easy measurement of Troponin T (cardiac) in biological samples. R-PLEX products leverage MSD’s electrochemiluminescence technology for better sensitivity and a larger dynamic range than traditional ELISAs. R-PLEX matched antibody sets enable the development of singleplex and multiplex immunoassays. Individual assays may be developed using MSD avidin- or streptavidin-coated plates. Custom multiplex assays with any combination of R-PLEX analytes, as well as R-PLEX plus U-PLEX analytes, can be developed on U-PLEX MULTI-SPOT plates. To learn more about the advantages of R-PLEX products
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R-PLEX Human Troponin T (cardiac) Antibody Set Features
- Measures human Troponin T (cardiac) in serum
- Dynamic range: 2.0 - 10,000 pg/mL
- Median LLOD: 2.0 pg/mL
- Can be used to develop individual analyte assays as well as multiplex panels
Typical Data
Calibration curve for the R-PLEX Human Troponin T (cardiac) Antibody Set was assessed and representative data are presented below.
Figure 1. R-PLEX Human Troponin T (cardiac) Antibody Set Calibration Curve
Troponin T (cardiac) Analyte
Description - Cardiac Troponin T (TNNT2, TnTC, cTnT) is one protein of a heterotrimer that regulates muscle contraction. Troponin acts with intracellular calcium to control the interaction of actin and myosin filaments in striated muscle fibers. When muscle tissue is damaged, the troponin-tropomyosin complex breaks down and troponin I and troponin T are released into the blood. Troponins are excellent biomarkers for myocardial injury in cardiotoxicity due to their tissue specificity, thus this antibody set is a useful tool in cardiovascular disease research.
Disease Research Area - Cardiovascular Disease
Application Area - Cardiac Injury, Cardiovascular, Cardiac Biomarkers
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Recommended Components
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Specifications
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Kit Contents
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References
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Resources
You will need plates, diluents, and read buffer to run your assay.
Please select from the below menu.
Catalog No.
Product Name
Size
L45SA-1
R50AA-4
R92TG-3
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Application(s)
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Cardiac Injury
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Toxicology
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Cardiac Biomarkers
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Cardiovascular
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Analyte(s)
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Troponin T (cardiac)
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Species
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Human
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Capture Antibody
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Mouse Monoclonal
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Detection Antibody
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Mouse Monoclonal
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Dynamic Range
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2.0 - 10,000 pg/mL
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Sample Type
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Serum
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LLOD (Sensitivity)
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2.0 pg/mL
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Storage Condition
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Multi-Component
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Gene ID
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7139
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UniProt ID
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P45379
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Assay Diluent(s)
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Diluent 7
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Antibody Diluent(s)
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Diluent 22
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Product Description
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Storage
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Quantity per Kit
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Human Troponin T (cardiac) Antibody Set (5 Plate Size)
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2-8°C | 1 ea
(5 plate size) |
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Human Troponin T (cardiac) Calibrator
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≤-70°C | 5 vial
(1 vial) |
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Product Description
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Storage
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Quantity per Kit
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Human Troponin T (cardiac) Antibody Set (5 Plate Size)
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2-8°C | 10 ea
(5 plate size) |
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Human Troponin T (cardiac) Calibrator
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≤-70°C | 50 vial
(1 vial) |
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Title
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Journal
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Year
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Cellular impedance assays for predictive preclinical drug screening of kinase inhibitor cardiovascular toxicity.
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Mild oxidative damage in the diabetic rat heart is attenuated by glyoxalase-1 overexpression.
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Biomarker panel of cardiac and skeletal muscle troponins, fatty acid binding protein 3 and myosin light chain 3 for the accurate diagnosis of cardiotoxicity and musculoskeletal toxicity in rats.
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No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days.
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Veterinary and toxicological applications for the detection of cardiac injury using cardiac troponin.
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