R-PLEX Human Troponin T (cardiac) Antibody Set Overview
The R-PLEX Human Troponin T (cardiac) Antibody Set includes a matched capture and detection antibody pair and calibrator for the quick and easy measurement of Troponin T (cardiac) in biological samples. R-PLEX products leverage MSD’s electrochemiluminescence technology for better sensitivity and a larger dynamic range than traditional ELISAs. R-PLEX matched antibody sets enable the development of singleplex and multiplex immunoassays. Individual assays may be developed using MSD avidin- or streptavidin-coated plates. Custom multiplex assays with any combination of R-PLEX analytes, as well as R-PLEX plus U-PLEX analytes, can be developed on U-PLEX MULTI-SPOT plates. To learn more about the advantages of R-PLEX products
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R-PLEX Human Troponin T (cardiac) Antibody Set Features
- Measures human Troponin T (cardiac) in serum
- Dynamic range: 2.0 - 10,000 pg/mL
- Median LLOD: 2.0 pg/mL
- Can be used to develop individual analyte assays as well as multiplex panels
Typical Data
Calibration curve for the R-PLEX Human Troponin T (cardiac) Antibody Set was assessed and representative data are presented below.
Figure 1. R-PLEX Human Troponin T (cardiac) Antibody Set Calibration Curve
Troponin T (cardiac) Analyte
Description - Cardiac Troponin T (TNNT2, TnTC, cTnT) is one protein of a heterotrimer that regulates muscle contraction. Troponin acts with intracellular calcium to control the interaction of actin and myosin filaments in striated muscle fibers. When muscle tissue is damaged, the troponin-tropomyosin complex breaks down and troponin I and troponin T are released into the blood. Troponins are excellent biomarkers for myocardial injury in cardiotoxicity due to their tissue specificity, thus this antibody set is a useful tool in cardiovascular disease research.
Disease Research Area - Cardiovascular Disease
Application Area - Cardiac Injury, Cardiovascular, Cardiac Biomarkers
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Recommended Components
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Specifications
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Kit Contents
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References
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Documentation
You will need plates, diluents, and read buffer to run your assay. Please select from the below menu.
R-PLEX Sets are intended to be used with other MSD components such as plates, diluents and MSD Read Buffer. If you don’t already have these items, you can purchase them along with your Antibody Set(s). The “Recommended Components” tab provides helpful suggestions or you can call MSD Customer Service (Phone number) for assistance. R-PLEX Sets can also be used with other antibody sets such as U-PLEX antibody sets (make a link to UPLEX landing page) for multiplex measurements.
Catalog No.
Product Name
Size
R50AA-4
R92TG-3
L45SA-1
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Application(s)
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Cardiac Injury
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Toxicology
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Cardiac Biomarkers
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Cardiovascular
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Analyte(s)
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Troponin T (cardiac)
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Species
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Human
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Capture Antibody
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Mouse Monoclonal
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Detection Antibody
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Mouse Monoclonal
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Dynamic Range
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2.0 - 10,000 pg/mL
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Sample Type
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Serum
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LLOD (Sensitivity)
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2.0 pg/mL
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Storage Condition
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Multi-Component
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Gene ID(s)
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7139
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UniProt ID(s)
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P45379
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Assay Diluent(s)
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Diluent 7
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Antibody Diluent(s)
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Diluent 22
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Product Description
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Storage
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Quantity per Kit
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Human Troponin T (cardiac) Antibody Set (5 Plate Size)
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2-8°C
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1 ea
(5 plate size)
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Human Troponin T (cardiac) Calibrator
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≤-70°C
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5 vial
(1 vial)
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Product Description
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Storage
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Quantity per Kit
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Human Troponin T (cardiac) Antibody Set (5 Plate Size)
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2-8°C
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10 ea
(5 plate size)
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Human Troponin T (cardiac) Calibrator
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≤-70°C
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50 vial
(1 vial)
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Title
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Journal
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Year
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Cellular impedance assays for predictive preclinical drug screening of kinase inhibitor cardiovascular toxicity.
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Mild oxidative damage in the diabetic rat heart is attenuated by glyoxalase-1 overexpression.
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Biomarker panel of cardiac and skeletal muscle troponins, fatty acid binding protein 3 and myosin light chain 3 for the accurate diagnosis of cardiotoxicity and musculoskeletal toxicity in rats.
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No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days.
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Veterinary and toxicological applications for the detection of cardiac injury using cardiac troponin.
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Product Inserts
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SDS
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Handouts
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Datasheets
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Order Details
Catalog No
Size
Price in USD
Qty
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