R-PLEX Human IL-6R Antibody Set Overview The R-PLEX Human IL-6R Antibody Set includes a matched capture and detection antibody pair and calibrator for the quick and easy measurement of IL-6R in biological samples. R-PLEX products leverage MSD’s electrochemiluminescence technology for better sensitivity and a larger dynamic range than traditional ELISAs. R-PLEX matched antibody sets enable the development of singleplex and multiplex immunoassays. Individual assays may be developed using MSD avidin- or streptavidin-coated plates. Custom multiplex assays with any combination of R-PLEX analytes, as well as R-PLEX plus U-PLEX analytes can be developed on U-PLEX MULTI-SPOT plates. To learn more about the advantages of R-PLEX products
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R-PLEX Human IL-6R Antibody Set Features - Measures human IL-6R in serum, plasma, and urine
- Dynamic range: 0.40 - 2,000 pg/mL
- Median LLOD: 0.40 pg/mL
- Can be used to develop individual analyte assays as well as multiplex panels
Typical Data Calibration curve for the R-PLEX Human IL-6R Antibody Set was assessed and representative data is presented below.
Figure 1. R-PLEX Human IL-6R Antibody Set Calibration Curve 
IL-6R Analyte
Description - Interleukin-6 Receptor (IL-6R, IL6Q, gp80, CD126, IL6RA, IL6RQ) is the receptor for a multi-functional cytokine that is produced by a variety of cell types. The receptor consists of two distinct membrane bound subunits, an 80 kDa alpha subunit (IL-6R) and a 130 kDa signal-transducing beta subunit (gp130). IL-6R is expressed by hepatocytes, monocytes, neutrophils, T cells, and B cells. IL-6 interacts with IL-6R with low affinity. The assay was developed to recognize the soluble version (Leu20-Asp358) /extracellular domain of IL-6R. The antibodies bind to the IL-6R subunit of the heterodimer (IL-6R/gp130). The assay should recognize monomer and heterodimer (interference testing has been done with GP130).
Disease Research Area - Rheumatoid Arthritis, Crohn's Disease, Irritable Bowel Disorder, Multiple Myeloma
Application Area - Immunology, Immunity
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Recommended Components
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Specifications
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Kit Contents
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References
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You will need plates, diluents, and read buffer to run your assay.
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Catalog No.
Product Name
Size
L45SA-1
R50AA-4
R92TG-3
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Application(s)
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Immunology/Inflammation
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Analyte(s)
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IL-6R
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Species
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Human
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Capture Antibody
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Mouse Monoclonal
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Detection Antibody
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Mouse Monoclonal
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Dynamic Range
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0.40 - 2,000 pg/mL
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Sample Type
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Serum, Plasma, Urine
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Recombinant standards
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Recombinant protein expressed in mouse myeloma cell line, NS0
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LLOD (Sensitivity)
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0.40 pg/mL
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Storage Statement
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Please refer to the product insert for the storage conditions of individual kit components.
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Storage Condition
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Multi-Component
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Gene ID
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3570
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UniProt ID
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P08887
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Assay Diluent(s)
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Diluent 7
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Antibody Diluent(s)
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Diluent 8
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Product Description
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Storage
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Quantity per Kit
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Human IL-6R Antibody Set (5 Plate Size)
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2-8°C | 1 ea
(5 plate size) |
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Human IL-6R Calibrator
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≤-70°C | 5 vial
(1 vial) |
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Product Description
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Storage
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Quantity per Kit
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Human IL-6R Antibody Set (5 Plate Size)
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2-8°C | 10 ea
(5 plate size) |
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Human IL-6R Calibrator
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≤-70°C | 50 vial
(1 vial) |
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Title
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Journal
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Year
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Inflammation biomarkers in vaginal fluid and preterm delivery.
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Is maternal obesity associated with sustained inflammation in extremely low gestational age newborns?
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The histone deacetylase inhibitor UCL67022 has potent activity in multiple myeloma and non-Hodgkin lymphoma pre-clinical models.
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A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly in anti-citrullinated peptide antibody-negative disease.
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Performance of a multi-biomarker score measuring rheumatoid arthritis disease activity in the CAMERA tight control study.
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