R-PLEX Human IL-6R Antibody Set

R-PLEX Human IL-6R Antibody Set Overview
The R-PLEX Human IL-6R Antibody Set includes a matched capture and detection antibody pair and calibrator for the quick and easy measurement of IL-6R in biological samples. R-PLEX products leverage MSD’s electrochemiluminescence technology for better sensitivity and a larger dynamic range than traditional ELISAs. R-PLEX matched antibody sets enable the development of singleplex and multiplex immunoassays. Individual assays may be developed using MSD avidin- or streptavidin-coated plates. Custom multiplex assays with any combination of R-PLEX analytes, as well as R-PLEX plus U-PLEX analytes can be developed on U-PLEX MULTI-SPOT plates. To learn more about the advantages of R-PLEX products click here.

R-PLEX Human IL-6R Antibody Set Features
  • Measures human IL-6R in serum, plasma, and urine
  • Dynamic range: 0.40 - 2,000 pg/mL
  • Median LLOD: 0.40 pg/mL
  • Can be used to develop individual analyte assays as well as multiplex panels

Typical Data
Calibration curve for the R-PLEX Human IL-6R Antibody Set was assessed and representative data is presented below.

Figure 1. R-PLEX Human IL-6R Antibody Set Calibration Curve
Calibration curve for R-PLEX Human IL-6R Antibody Set
IL-6R Analyte

Description - Interleukin-6 Receptor (IL-6R, IL6Q, gp80, CD126, IL6RA, IL6RQ) is the receptor for a multi-functional cytokine that is produced by a variety of cell types. The receptor consists of two distinct membrane bound subunits, an 80 kDa alpha subunit (IL-6R) and a 130 kDa signal-transducing beta subunit (gp130). IL-6R is expressed by hepatocytes, monocytes, neutrophils, T cells, and B cells. IL-6 interacts with IL-6R with low affinity. The assay was developed to recognize the soluble version (Leu20-Asp358) /extracellular domain of IL-6R. The antibodies bind to the IL-6R subunit  of the heterodimer (IL-6R/gp130). The assay should recognize monomer and heterodimer (interference testing has been done with GP130).

Disease Research Area - Rheumatoid Arthritis, Crohn's Disease, Irritable Bowel Disorder, Multiple Myeloma

Application Area - Immunology, Immunity

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5 plate size
50 plate size
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