R-PLEX Human IL-6R Antibody Set Overview The R-PLEX Human IL-6R Antibody Set includes a matched capture and detection antibody pair and calibrator for the quick and easy measurement of IL-6R in biological samples. R-PLEX products leverage MSD’s electrochemiluminescence technology for better sensitivity and a larger dynamic range than traditional ELISAs. R-PLEX matched antibody sets enable the development of singleplex and multiplex immunoassays. Individual assays may be developed using MSD avidin- or streptavidin-coated plates. Custom multiplex assays with any combination of R-PLEX analytes, as well as R-PLEX plus U-PLEX analytes can be developed on U-PLEX MULTI-SPOT plates. To learn more about the advantages of R-PLEX products
click here.
R-PLEX Human IL-6R Antibody Set Features - Measures human IL-6R in serum, plasma, and urine
- Dynamic range: 0.40 - 2,000 pg/mL
- Median LLOD: 0.40 pg/mL
- Can be used to develop individual analyte assays as well as multiplex panels
Typical Data Calibration curve for the R-PLEX Human IL-6R Antibody Set was assessed and representative data is presented below.
Figure 1. R-PLEX Human IL-6R Antibody Set Calibration Curve 
IL-6R Analyte
Description - Interleukin-6 Receptor (IL-6R, IL6Q, gp80, CD126, IL6RA, IL6RQ) is the receptor for a multi-functional cytokine that is produced by a variety of cell types. The receptor consists of two distinct membrane bound subunits, an 80 kDa alpha subunit (IL-6R) and a 130 kDa signal-transducing beta subunit (gp130). IL-6R is expressed by hepatocytes, monocytes, neutrophils, T cells, and B cells. IL-6 interacts with IL-6R with low affinity. The assay was developed to recognize the soluble version (Leu20-Asp358) /extracellular domain of IL-6R. The antibodies bind to the IL-6R subunit of the heterodimer (IL-6R/gp130). The assay should recognize monomer and heterodimer (interference testing has been done with GP130).
Disease Research Area - Rheumatoid Arthritis, Crohn's Disease, Irritable Bowel Disorder, Multiple Myeloma
Application Area - Immunology, Immunity
-
Recommended Components
-
Specifications
-
Kit Contents
-
References
-
Documentation
You will need plates, diluents, and read buffer to run your assay. Please select from the below menu.
R-PLEX Sets are intended to be used with other MSD components such as plates, diluents and MSD Read Buffer. If you don’t already have these items, you can purchase them along with your Antibody Set(s). The “Recommended Components” tab provides helpful suggestions or you can call MSD Customer Service (Phone number) for assistance. R-PLEX Sets can also be used with other antibody sets such as U-PLEX antibody sets (make a link to UPLEX landing page) for multiplex measurements.
Catalog No.
Product Name
Size
R50AA-4
R92TG-3
L45SA-1
|
Application(s)
|
|
Immunology/Inflammation
|
|
Analyte(s)
|
|
IL-6R
|
|
Species
|
|
Human
|
|
Capture Antibody
|
|
Mouse Monoclonal
|
|
Detection Antibody
|
|
Mouse Monoclonal
|
|
Dynamic Range
|
|
0.40 - 2,000 pg/mL
|
|
Sample Type
|
|
Serum, Plasma, Urine
|
|
Recombinant standards
|
|
Recombinant protein expressed in mouse myeloma cell line, NS0
|
|
LLOD (Sensitivity)
|
|
0.40 pg/mL
|
|
Usage Statement
|
|
For Research Use Only. Not for use in diagnostic procedures.
|
|
Storage Statement(s)
|
|
Please refer to the product insert for the storage conditions of individual kit components.
|
|
Storage Condition
|
|
Multi-Component
|
|
Gene ID(s)
|
|
3570
|
|
UniProt ID(s)
|
|
P08887
|
|
Assay Diluent(s)
|
|
Diluent 7
|
|
Antibody Diluent(s)
|
|
Diluent 8
|
|
|
Product Description
|
Storage
|
Quantity per Kit
|
|
Human IL-6R Antibody Set (5 Plate Size)
|
2-8°C
|
1 ea
(5 plate size)
|
|
|
|
Human IL-6R Calibrator
|
≤-70°C
|
5 vial
(1 vial)
|
|
|
|
Product Description
|
Storage
|
Quantity per Kit
|
|
Human IL-6R Antibody Set (5 Plate Size)
|
2-8°C
|
10 ea
(5 plate size)
|
|
|
|
Human IL-6R Calibrator
|
≤-70°C
|
50 vial
(1 vial)
|
|
|
|
Title
|
Journal
|
Year
|
|
Inflammation biomarkers in vaginal fluid and preterm delivery.
|
|
|
|
Is maternal obesity associated with sustained inflammation in extremely low gestational age newborns?
|
|
|
|
The histone deacetylase inhibitor UCL67022 has potent activity in multiple myeloma and non-Hodgkin lymphoma pre-clinical models.
|
|
|
|
A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly in anti-citrullinated peptide antibody-negative disease.
|
|
|
|
Performance of a multi-biomarker score measuring rheumatoid arthritis disease activity in the CAMERA tight control study.
|
|
|
|
|
View All
|
|
Product Inserts
|
|
|
|
Product Highlights
|
|
|
|
SDS
|
|
|
|
Handouts
|
|
|
|
Datasheets
|
|
|
Order Details
Catalog No
Size
Price in USD
Qty
Customer Service/Orders
Scientific/Technical Support
Instrument Support
Company Headquarters