R-PLEX Human IL-6R Antibody Set Overview The R-PLEX Human IL-6R Antibody Set includes a matched capture and detection antibody pair and calibrator for the quick and easy measurement of IL-6R in biological samples. R-PLEX products leverage MSD’s electrochemiluminescence technology for better sensitivity and a larger dynamic range than traditional ELISAs. R-PLEX matched antibody sets enable the development of singleplex and multiplex immunoassays. Individual assays may be developed using MSD avidin- or streptavidin-coated plates. Custom multiplex assays with any combination of R-PLEX analytes, as well as R-PLEX plus U-PLEX analytes can be developed on U-PLEX MULTI-SPOT plates. To learn more about the advantages of R-PLEX products
click here.
R-PLEX Human IL-6R Antibody Set Features - Measures human IL-6R in serum, plasma, and urine
- Dynamic range: 0.40 - 2,000 pg/mL
- Median LLOD: 0.40 pg/mL
- Can be used to develop individual analyte assays as well as multiplex panels
Typical Data Calibration curve for the R-PLEX Human IL-6R Antibody Set was assessed and representative data is presented below.
Figure 1. R-PLEX Human IL-6R Antibody Set Calibration Curve 
IL-6R Analyte
Description - Interleukin-6 Receptor (IL-6R, IL6Q, gp80, CD126, IL6RA, IL6RQ) is the receptor for a multi-functional cytokine that is produced by a variety of cell types. The receptor consists of two distinct membrane bound subunits, an 80 kDa alpha subunit (IL-6R) and a 130 kDa signal-transducing beta subunit (gp130). IL-6R is expressed by hepatocytes, monocytes, neutrophils, T cells, and B cells. IL-6 interacts with IL-6R with low affinity. The assay was developed to recognize the soluble version (Leu20-Asp358) /extracellular domain of IL-6R. The antibodies bind to the IL-6R subunit of the heterodimer (IL-6R/gp130). The assay should recognize monomer and heterodimer (interference testing has been done with GP130).
Disease Research Area - Rheumatoid Arthritis, Crohn's Disease, Irritable Bowel Disorder, Multiple Myeloma
Application Area - Immunology, Immunity
-
Recommended Components
-
Specifications
-
Kit Contents
-
References
-
Documentation
Why do I need other components
Catalog No.
Product Name
Size
R50AA-4
R92TG-3
L45SA-1
|
Application(s)
|
|
Immunology/Inflammation
|
|
Analyte(s)
|
|
IL-6R
|
|
Species
|
|
Human
|
|
Capture Antibody
|
|
Mouse Monoclonal
|
|
Detection Antibody
|
|
Mouse Monoclonal
|
|
Dynamic Range
|
|
0.40 - 2,000 pg/mL
|
|
Sample Type
|
|
Serum, Plasma, Urine
|
|
Recombinant standards
|
|
Recombinant protein expressed in mouse myeloma cell line, NS0
|
|
LLOD (Sensitivity)
|
|
0.40 pg/mL
|
|
Usage Statement
|
|
For Research Use Only. Not for use in diagnostic procedures.
|
|
Storage Statement(s)
|
|
Please refer to the product insert for the storage conditions of individual kit components.
|
|
Storage Condition
|
|
Multi-Component
|
|
Gene ID(s)
|
|
3570
|
|
UniProt ID(s)
|
|
P08887
|
|
Assay Diluent(s)
|
|
Diluent 7
|
|
Antibody Diluent(s)
|
|
Diluent 8
|
|
|
Product Description
|
Storage
|
Quantity per Kit
|
|
Human IL-6R Antibody Set (5 Plate Size)
|
2-8°C
|
1 ea
(5 plate size)
|
|
|
|
Human IL-6R Calibrator
|
≤-70°C
|
5 vial
(1 vial)
|
|
|
|
Product Description
|
Storage
|
Quantity per Kit
|
|
Human IL-6R Antibody Set (5 Plate Size)
|
2-8°C
|
10 ea
(5 plate size)
|
|
|
|
Human IL-6R Calibrator
|
≤-70°C
|
50 vial
(1 vial)
|
|
|
|
Title
|
Journal
|
Year
|
|
Inflammation biomarkers in vaginal fluid and preterm delivery.
|
|
|
|
Is maternal obesity associated with sustained inflammation in extremely low gestational age newborns?
|
|
|
|
The histone deacetylase inhibitor UCL67022 has potent activity in multiple myeloma and non-Hodgkin lymphoma pre-clinical models.
|
|
|
|
A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly in anti-citrullinated peptide antibody-negative disease.
|
|
|
|
Performance of a multi-biomarker score measuring rheumatoid arthritis disease activity in the CAMERA tight control study.
|
|
|
|
|
View All
|
|
Product Inserts
|
|
|
|
Product Highlights
|
|
|
|
SDS
|
|
|
|
Handouts
|
|
|
|
Datasheets
|
|
|
Order Details
Catalog No
Size
Price in USD
Qty
Customer Service/Orders
Scientific/Technical Support
Instrument Support
Company Headquarters