V-PLEX Mouse TNF-α Kit


Mouse tumor necrosis factor alpha (TNF-α), also known as tumor necrosis factor ligand superfamily member 2 (TNFSF2) and cachectin, is a 25.9 kDa cytokine. TNF is a transmembrane protein that oligomerizes intracellularly to form a non-covalent homotrimer. The membrane-bound soluble portion of the homotrimer is cleaved by TACE/ADAM17 to form TNF-α. The homotrimer binds to the receptors TNF RI and TNF RII, both of which are also expressed as homotrimers. TNF-α is mainly secreted by macrophages and can induce apoptosis in some tumor cell lines. It stimulates IL-1, which induces cachexia and causes fever. The intracellular form of TNF induces IL-12 production in dendritic cells. It can induce sepsis and inflammation and can inhibit tumorigenesis and viral replication. The Mouse TNF-α Kit provides assay-specific components for the quantitative determination of endogenous TNF-α in mouse urine, serum, plasma, and cell culture supernatants.

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25 plates
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