Mouse interleukin-12p70 (IL-12p70) is a disulfide-linked heterodimer consisting of IL-12a (p35 subunit) and IL-12b (p40 subunit) that is mainly produced by macrophages and T lymphocytes. The IL-12a subunit also dimerizes with Ebi3 to form IL-35, and the IL-12b subunit dimerizes with IL-23a to form IL-23. IL-12, IL-23, IL-27, and IL-35 are all heterodimeric proteins and members of IL-12 cytokine family. IL-12p70 activates T cells and natural killer cells that stimulate the production of IFN-γ. It is involved in a number of disorders including peritonitis and chronic toxoplasmosis.The Mouse IL-12p70 Kit provides assay-specific components for the quantitative determination of endogenous IL-12p70 in mouse urine, serum, plasma, and cell culture supernatants.
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Specifications
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Kit Contents
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Documentation
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References
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Application(s)
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Cytokines & Chemokines
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Immunology/Inflammation
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Analyte(s)
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IL-12p70
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Species
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Mouse
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Instrument
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MESO QuickPlex SQ 120
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SECTOR Imager 2400
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SECTOR Imager 6000
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MESO SECTOR S 600
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Plate Type
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96-well
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Capture Antibody
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Rat Monoclonal
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Detection Antibody
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Rat Monoclonal
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LLOD (Sensitivity)
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9.95 pg/mL
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Dynamic Range
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9.95–20 600 pg/mL
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Sample Type
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Serum, Plasma, Urine, Cell Culture Supernatant
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Recombinant standards
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Expressed in Sf21 insect cells
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Storage Statement(s)
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Please refer to the product insert for the storage conditions of individual kit components.
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Storage Condition
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Multi-Component
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Product Description
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Storage
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Quantity per Kit
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2-8 °C
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1 vial
(1 vial)
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2-8 °C
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1 vial
(75 μL)
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Proinflammatory Panel 1 (mouse) Plate
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2-8 °C
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1 each
(1 each)
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Diluent Assembly 5 (includes Diluent 41 - 10 mL, and Diluent 45 - 5 mL)
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≤-10 °C
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1 each
(1 each)
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RT
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1 bottle
(50 mL)
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Product Description
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Storage
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Quantity per Kit
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2-8 °C
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5 vial
(1 vial)
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2-8 °C
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1 vial
(375 μL)
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Proinflammatory Panel 1 (mouse) Plate
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2-8 °C
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5 each
(1 each)
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Diluent Assembly 6 (includes Diluent 41 - 50 mL, and Diluent 45 - 25 mL)
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≤-10 °C
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1 each
(1 each)
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RT
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1 bottle
(50 mL)
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Product Description
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Storage
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Quantity per Kit
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2-8 °C
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25 vial
(1 vial)
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2-8 °C
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5 vial
(375 μL)
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Proinflammatory Panel 1 (mouse) Plate
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2-8 °C
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25 each
(1 each)
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Diluent Assembly 6 (includes Diluent 41 - 50 mL, and Diluent 45 - 25 mL)
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≤-10 °C
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5 each
(1 each)
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RT
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5 bottle
(50 mL)
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Product Inserts
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Product Highlights
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Certificate of analysis
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SDS
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Kit Layout (Add-in)
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Title
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Journal
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Year
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Galectin-9, a Player in Cytokine Release Syndrome and a Surrogate Diagnostic Biomarker in SARS-CoV-2 Infection
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Reliability of self-sampling for accurate assessment of respiratory virus viral and immunologic kinetics
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Protection Against Lethal Multidrug-Resistant Bacterial Infections Using Macrophage Cell Therapy
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Cytokine biomarkers in tear film for primary open-angle glaucoma
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A Pilot Study of Preoperative Single-Dose Ipilimumab and/or Cryoablation in Women with Early-Stage Breast Cancer with Comprehensive Immune Profiling.
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