| References | Journal | Year | |
Tumor necrosis factor-alpha regulates inflammatory and mesenchymal responses via mitogen-activated protein kinase kinase, p38, and nuclear factor kappaB in human endometriotic epithelial cells.
Grund, E.M., Kagan, D., Tran, C.A., Zeitvogel, A., Starzinski-Powitz, A., Nataraja, S., Palmer, S.S. | Mol Pharmacol. | 2008 | View |
A Fragment-Based Approach for the Discovery of Isoform-Specific p38 Inhibitors.
Chen, J.H., Zhang, Z.M. Stebbins J.L., Zhang, X.Y., Hoffman, R., Moore, A., Pellecchia, M. | ACS Chem Bio. | 2007 | View |
Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival.
Cho, S., Hu, Y. | Exp Neurol. | 2007 | View |
An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor alpha.
Koivunen, P., Tiainen, P., Hyvarinen, J., Williams, K.E., Sormunen, R., Klaus, S.J., Kivirikko, K.I., Myllyharju, J. | J Biol Chem. | 2007 | View |
Application of Meso Scale Technology for the Measurement of Phosphoproteins in Human Tumor Xenografts.
Gowan, S.M., Hardcastle, A., Hallsworth, A.E., Valenti, M.R., Hunter, L.J., de Haven Brandon, A.K., Garrett, M.D., Raynaud, F., Workman, P., Aherne, W., Eccles, S.A. | Assay and Drug Dev Technol. | 2007 | View |
AZD2171, a Pan-VEGF receptor tyrosine Kinase Inhibitor, Normalizes tumor vasculature and alleviates edema in glioblastoma patients.
Batchelor, T., Sorensen, A.G., di Tomaso, E., Zhang, W.T., Duda, D.G., Cohen, K.S., Kozak, K.R., Cahill, D.P., Chen, P.J., Zhu, M., Ancukiewicz, M., Mrugala, M.M., Plotkin, S., Drappatz, J., Louis, D.N., Ivy, P., Scadden, D.T., Benner, T., Loeffler, J.S., Wen, P.Y., Jain, R.K. | Cancer Cell. | 2007 | View |
Biomarker Development Strategies - surmounting scientific and regulatory barriers in bringing innovative medicine to market.
Shi, M. | IDrugs. | 2007 | View |
Biomarkers of leukocyte traffic and activation in the vaginal mucosa.
Trifonova, R.T., Bajpai, M., Pasicznyk, J.M., Chandra, N., Doncel, G.F., Fichorova, R.N. | Biomarkers. | 2007 | View |
Cathepsin K null mice show reduced adiposity during the rapid accumulation of fat stores.
Funicello, M., Novelli, M., Ragni, M., Vottari, T., Cocuzza, C., Soriano-Lopez, J., Chiellini, C., Boschi, F., Marzola, P., Masiello, P., Saftig, P., Santini, F., St-Jacques, R., Desmarais, S., Morin, N., Mancini, J., Percival, M.D., Pinchera, A., Maffei, M. | PLoS ONE | 2007 | View |
Characterization of the epitope for anti-human respiratory syncytial virus F protein monoclonal antibody 101F using synthetic peptides and genetic approaches.
Wu, S.J., Schmidt, A., Beil, E.J., Day, N.D., Branigan, P.J., Liu, C., Gutshall, L.L., Palomo, C., Furze, J., Taylor, G., Melero, J.A., Tsui, P., Del Vecchio, A.M., Kruszynski, M. | J Gen Virol. | 2007 | View |
Cloning and characterization of the hamster and guinea pig nicotinic acid receptors.
Torhan, A.S., Cheewatrakoolpong, B., Kwee, L., Greenfeder, S. | J Lipid Res. | 2007 | View |
Comparing ELISA and surface plasmon resonance for assessing clinical immunogenicity of panitumumab.
Lofgren, J.A., Dhandapani, S., Pennucci, J.J., Abbott, C.M., Mytych, D.T., Kaliyaperumal, A., Swanson, S.J., Mullenix, M.C. | J Immunol Methods | 2007 | View |
Comparison of an electrochemiluminescence assay in plate format over a colorimetric ELISA, for the detection of ricin B chain (RCA-B).
Guglielmo-Viret, V., Thullier, P. | J Immunol Methods | 2007 | View |
Detecting and Responding to Bioterrorism in Risk Assessment and Risk Communication Strategies in Bioterrorism Preparedness. (Book Chapter)
Blatny, J.M.. | ed. Green, M.S | 2007 | View |
Detection of High- and Low-Affinity Antibodies Against a Human Monoclonal Antibody Using Various Technology Platforms.
Liang, M., Klakamp S.L., Funelas, C., Lu, H., Lam, B., Herl, C., Umble, A., Drake, A.W., Pak, M., Ageyeva, N., Pasumarthi, R., Roskos, L. | Assay and Drug Dev Technol. | 2007 | View |
ECL-Electrochemical luminescence.
Pyati, R., Richter, M.M. | Annu. Rep. Prog. Chem. | 2007 | View |
Electrochemiluminescence to detect surface proteins on live cells.
Lu, Y., Young, J., Meng, Y.G. | Current Op Pharmacology. | 2007 | View |
Electrochemiluminescence Detection in Bioanalysis
Xu, X.H.N, Zu, Y. | New Frontiers in Ultrasensitive Bioanalysis. | 2007 | View |
Evaluation of Antibodies in Clinical Trials of Cytokines (Book chapter)
Swanson, S. | Cytokines in Human Health: Methods in Pharmacology and Toxicology | 2007 | View |
Generation of Ab38 and Ab42 Is Independently and Differentially Affected by Familial Alzheimer Disease-associated Presenilin Mutations and gamma-Secretase Modulation.
Page, R.M., Baumann,K., Tomioka, M., Pérez-Revuelta, B.I., Fukumori, A., Jacobsen, H., Flohr, A., Luebbers, T., Ozmen, L., Steiner, H., Haass, C. | J Biol Chem. | 2007 | View |
Glial activation links early-life seizures and long-term neurologic dysfunction: evidence using a small molecule inhibitor of proinflammatory cytokine upregulation.
Somera-Molina, K.C., Robin B., Somera, C.A., Anderson, C., Stine, C., Koh, S., Behanna, H.A., Van Eldik, L.J., Watterson, D.M., Wainwright, M.S. | Epilepsia. | 2007 | View |
Identification of a novel series of benzimidazoles as potent and selective antagonists of the human melanocortin-4 receptor.
Poitout, L., Brault, V., Sackur, C., Bernetiere, S., Camara, J., Plas, P., Roubert, P. | Bioorg Med Chem Lett | 2007 | View |
Immune function in young children with previous pulmonary or miliary/meningeal tuberculosis and impact of BCG vaccination.
Sterling T.R., Martire, T., de Almeida, A.S., Ding, L., Greenberg, D.E., Moreira, L.A., Elloumi, H., Torres, A.P., Sant'Anna, C.C., Calazans, E., Paraguassu, G., Gebretsadik, T., Shintani, A., Miller, K., Kritski, A., Lapa e Silva, J.R., Holland, S.M. | Pediatrics. | 2007 | View |
Immunobiological aspects of therapeutic antibodies and related characterization approaches.
Liu, P.M, Handl, H., Zou, L, Kim, B. | Curr Opin Drug Discov Devel. | 2007 | View |
Immunogenicity Issues in the Development of Therapeutic Proteins.
Swanson, S. J. | Intl J Pharm Med. | 2007 | View |
Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection.
Lutterloh, E.C., Opal, S.M., Pittman, D.D., Keith, J.C., Tan, X.Y., Clancy, B.M., Palmer, H., Milarski, K., Sun, Y., Palardy, J.E., Parejo, N.A., Kessimian, N. | Crit Care. | 2007 | View |
Insulin Sensitizing Pharmacology of Thiazolidinediones Correlates with Mitochondrial Gene Expression rather than Activation of PPARg.
Bolten, C. W., Blanner, P.M., McDonald, W.G., Staten, N.R., Mazzarella, R.A., Arhancet, G.B., Meier, M.F., Weiss, D.J., Sullivan, P.M., Hromockyj, A.E., Kletzien, R.F., Colca, J.R. | Gene Regulation and Systems Biology. | 2007 | View |
Investigating Toll-like receptor agonists for potential to treat hepatitis C virus infection.
Thomas, A., Laxton, C., Rodman, J., Myangar, N., Horscroft, N., Parkinson, T. | Antimicrob Agents Chemother. | 2007 | View |
Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor gamma coactivator 1 beta and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice.
Yang, R., Wilcox, D.M., Haasch, D.L., Jung, P.M., Nguyen, P.T., Voorbach, M.J., Doktor, S., Brodjian, S., Bush, E.N., Lin, E., Jacobson, P.B., Collins, C.A., Landschulz, K.T., Trevillyan, J.M., Rondinone, C.M., Surowy, T.K. | J Biol Chem. | 2007 | View |
LPS-induced biomarkers in mice: a potential model for identifying insulin sensitizers.
Briscoe, C.P., Looper, D., Tran, P., Herrera, J., McDonnell, S.R., Bhat, B.G. | Biochem Biophys Res Commun. | 2007 | View |
Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity.
Chan, F., Sun, C., Perumal, M., Nguyen, Q.D., Bavetsias, V., McDonald, E., Martins, V., Wilsher, N.E., Raynaud, F.I., Valenti, M., Eccles, S., Te Poele, R., Workman, P., Aboagye, E.O., Linardopoulos, S. | Mol Cancer Ther. | 2007 | View |
Multiplexing siRNAs to compress RNAi-based screen size in human cells.
Martin, S.E., Jones, T.L., Thomas, C.L., Lorenzi, P.L., Nguyen, D.A., Runfola, T., Gunsior, M., Weinstein, J.N., Goldsmith, P.K., Lader, E., Huppi, K., Caplen, N.J. | Nucleic Acids Res. | 2007 | View |
Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
Hussain, I., Hawkins, J., Harrison, D., Hille, C., Wayne, G., Cutler, L., Buck, T., Walter, D., Demont, E., Howes, C., Naylor, A., Jeffrey, P., Gonzalez, M.I., Dingwall, C., Michel, A., Redshaw, S., Davis, J.B. | J Neurochem. | 2007 | View |
Ovarian cancer cell-derived migration inhibitory factor enhances tumor growth, progression, and angiogenesis.
Hagemann, T., Robinson, S.C., Thompson, R.G., Charles, K., Kulbe, H., Balkwill, F.R. | Mol Cancer Ther. | 2007 | View |
Patholocial activity of familial Alzheimer’s disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.
Shirotani, K., Tomioka, M., Kremmer, E., Haass, C., Steiner, H. | Neurobiology of Disease | 2007 | View |
Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood.
Hall, J.P., Kurdi Y., Hsu S., Cuozzo J., Liu J., Telliez J.B., Seidl K.J., Winkler, A., Hu, Y., Green, N., Askew, G.R., Tam, S., Clark, J.D., Lin, L.L. | J Biol Chem. | 2007 | View |
Pharmacological properties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in an in vivo model of respiratory inflammatory disease.
Salter, M., Biggadike, K., Matthews, J.L., West, M.R., Haase, M.V., Farrow, S.N., Uings, I.J, Gray, D.W. ( | Am J Physiol Lung Cell Mol Physiol. | 2007 | View |
Pharmacological Characterization of a Potent Inhibitor of Class I Phosphotidylinositide 3-Kinases.
Raynaud, F.I., Eccles, S., Clarke, P.A., Hayes, A., Nutley, B., Alix, S., Henley, A., Di-Stefano, F., Ahmad, Z., Guillard, S., Bjerke, L.M., Kelland, L., Valenti, M., Patterson, L., Gowan, S., de Haven Brandon, A., Hayakawa, M., Kaizawa, H., Koizumi, T., Ohishi, T., Patel, S., Saghir, N., Parker, P., Waterfield, M., Workman, P. | Cancer Res. | 2007 | View |
Phosphorylation of APP695 at Thr668 decreases g-cleavage and extracellular Ab.
Feyt, C., Pierrot, N., Tasiaux, B., Van Hees, J., Kienlen-Campard, P., Courtoy, P.J., Octave, J. | Biochem Biophys Res Commun. | 2007 | View |
Purification of soluble CD14 fusion proteins and the use in an electrochemiluminescent assay for lipopolysaccharide binding.
Burkhardt, M., Lopez-Acosta, A., Reiter, K., Lopes, V., Lees A. | Protein Expr Purif. | 2007 | View |
Rab10 is Involved in Basolateral Transport in Polarized Madin-Darby Canine Kidney Cells.
Schuck, S., Gerl M.J., Ang, A., Manninen, A., Keller, P., Mellman, I., Simons, K. | Traffic. | 2007 | View |
Safety, pharmacokinetics, and efficacy of AMG 706, an oral multikinase inhibitor, in patients with advanced solid tumors.
Rosen, L., Kurzrock, R., Mulay, M., Van Vugt, A., Purdom, M., Ng, C., Silverman, J., Koutsoukos, A., Sun, Y.N., Bass, M.B., Xu, R.Y., Polverino, A., Wiezorek, J.S., Chang, D.D., Benjamin, R., Herbst, R.S. | Clin Oncol. | 2007 | View |
Staphylococcus aureus enterotoxin B, protein A, and lipoteichoic acid stimulations in nasal polyps.
Patou, J., Gevaert, P., Van Zele, T., Holtappels, G., van Cauwenberge, P., Bachert, C. | J Allergy Clin Immunol. | 2007 | View |
STAT3 Mutations in the Hyper-IgE Syndrome.
Holland, S.M., DeLeo, F.R., Elloumi, H.Z., Hsu, A.P., Uzel, G., Brodsky, N., Freeman, A.F., Demidowich, A., Davis, J., Turner, M.L., Anderson, V.L., Darnell, D.N., Welch, P.A., Kuhns, D.B., Frucht, D.M., Malech, H.L., Gallin, J.I., Kobayashi, S.D., Whitney, A.R., Voyich, J.M., Musser, J.M., Woellner, C., Schäffer, A.A., Puck, J.M., Grimbacher, B. | New England J Med. | 2007 | View |
Sub-pyrogenic systemic inflammation impacts on brain and behavior, independent of cytokines.
Teeling, J.L., Felton, L.M., Deacon, R.M.J., Cunningham, C., Rawlins, J.N.P., Perry V.H. | Brain Behavior and Immunity | 2007 | View |
The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease.
Riddell, D.R., Zhou, H., Comery, T.A., Kouranova, E., Lo, C.F., Warwick, H.K., Ring, R.H., Kirksey, Y., Aschmies, S., Xu, J., Kubek, K., Hirst, W.D., Gonzales, C., Chen, Y., Murphy, E., Leonard, S., Vasylyev, D., Oganesian, A., Martone, R.L., Pangalos, M.N., Reinhart, P.H., Jacobsen, J.S. | Mol Cell Neurosci. | 2007 | View |
The Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinases MK2 and MK3 Cooperate in Stimulation of Tumor Necrosis Factor Biosynthesis and Stabilization of p38 MAPK.
Ronkina, N., Kotlyarov, A., Dittrich-Breiholz, O., Kracht, M., Hitti, E., Milarski, K. | Mol Cell Biol. | 2007 | View |
The Novel gamma-Secretase Inhibitor N-[cis-4-[(4- Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1- trifluoromethanesulfonamide (MRK-560) Reduces Amyloid Plaque Deposition without Evidence of Notch-Related Pathology in the Tg2576 Mouse.
Best, J.D., Smith, D.W., Reilly, M.A., O'Donnell, R., Lewis, H.D., Ellis, S., Wilkie, N., Rosahl, T.W., Laroque, P.A., Boussiquet-Leroux, C., Churcher, I., Atack, J.R., Harrison, T., Shearman, M.S. | J Pharmacol Exp Ther. | 2007 | View |
TLR-TLR cross talk in human PBMC resulting in synergistic and antagonistic regulation of type-1 and 2 interferons, IL-12 and TNF-alpha.
Ghosh, T.K., Michelson, D.J., Solberg, J.C., Lipson, K.E., Inglefield, J.R., Alkan, S.S. | Int Immunopharmacol. | 2007 | View |
Use of a cytokine gene expression signature in lung adenocarcinoma and the surrounding tissue as a prognostic classifier.
Seike, M., Yanaihara, N., Bowman, E.D., Zanetti, K.A., Budhu, A., Kumamoto, K., Mechanic, L.E., Matsumoto, S., Yokota, J., Shibata, T., Sugimura, H., Gemma, A., Kudoh, S., Wang, X.W., Harris, C.C. | J Natl Cancer Inst. | 2007 | View |
Use of pharmacokinetic/ pharmacodynamic biomarkers to support rational cancer drug development.
Sarker, D., Pacey, S., Workman, P. | Biomarkers in Medicine | 2007 | View |
Validation of amyloid-beta peptides in CSF diagnosis of neurodegenerative dementias.
Bibl, M., Mollenhauer, B., Lewczuk, P., Esselmann, H., Wolf, S, Trenkwalder, C., Otto, M., Stiens G., Rüther, E., Kornhuber, J., Wiltfang, J. | Mol Psychiatry. | 2007 | View |
A comparative assessment of g-secretase activity in transgenic and non-transgenic rodent brain.
Goggi, J.L., Lewis, H.D., Mok, J., Harrison, T., Shearman, M.S., Atack, J.R., Best, J.D. | J. Neurosci Methods. | 2006 | View |
A high throughput electrochemiluminescent cell-binding assay for therapeutic anti-CD20 antibody selection.
Lu, Y., Wong, W.L., Meng, Y.G. | J Immunological Methods. | 2006 | View |
A Model for Efficient Assay Development and Screening at a Small Research Site.
Simpson, P.B. | J. Assoc. Lab Automation. | 2006 | View |
Alzheimer's disease beta-amyloid peptides are released in association with exosomes.
Rajendran, L., Honsho, M., Zahn, T.R., Keller, P., Geiger, K.D., Verkade, P., Simons, K. | Proc Natl Acad Sci USA. | 2006 | View |
Anticancer Activity of BIM-46174, a New Inhibitor of the Heterotrimeric Ga/Gßg Protein Complex.
Prevost, G.P., Lonchampt, M.O., Holbeck, S., Attoub, S., Zaharevitz, D., Alley, M., Wright, J., Brezak, M.C., Coulomb, H., Savola, A., Huchet, M., Chaumeron, S., Nguyen, Q.D., Forgez, P., Bruyneel, E., Bracke, M., Ferrandis, E., Roubert, P., Demarquay, D., Gespach, C., Kasprzyk, P.G. | Cancer Res. | 2006 | View |
Bile acids induce adhesion molecule expression in endothelial cells through activation of reactive oxygen species, NF-kB, and p38.
Qin, P., Tang, X., Elloso, M.M., Harnish, D.C. | Am J Physiol Heart Circ Physiol. | 2006 | View |
Biocompatibility of solid-dosage forms of anti-human immunodeficiency virus type 1 microbicides with the human cervicovaginal mucosa modeled ex vivo.
Trifonova, R.T., Pasicznyk, J.M., Fichorova, R.N. | Antimicrobial Agents and Chemotherapy. | 2006 | View |
Changes in hepatitis C virus (HCV) viral load and interferon-alpha levels in HIV/HCV-coinfected patients treated with highly active antiretroviral therapy.
Bower, W.A., Culver, D.H., Castor, D., Wu, Y., James, V.N., Zheng, H., Hammer, S., Kuhnert, W.L., Williams, I.T., Bell, B.P., Vlahov, D., Dezzutti, C.S. | J Acquir Immune Defic Syndr. | 2006 | View |
Characterization of adenosine receptors in the human bladder carcinoma T24 cell line.
Phelps, T., Anthes, J.C., Correll, C.C. | Euro J Pharmacol. | 2006 | View |
c-Met Ectodomain Shedding Rate Correlates with Malignant Potential.
Athauda, G., Giubellino, A., Coleman, J.A., Horak, C., Steeg, P.S., Lee, M.J., Trepel, J., Wimberly, J., Sun, J., Coxon, A., Burgess, T.L., Bottaro, D.P. | Clin Cancer Res. | 2006 | View |
Effect of renal function on the pharmacokinetics of palifermin.
Gillespie, B., Zia-Amirhosseini, P., Salfi, M., Kakkar, T., Wang, J., Gupta, S., Smith, B., Robson, R., Sullivan J.T. | J Clin Pharmacol. | 2006 | View |
Glia as a Therapeutic Target: Selective Suppression of Human Amyloid-Beta Induced Upregulation of Brain Proinflammatory Cytokine Production Attenuates Neurodegeneration.
Ranaivo, H.R., Craft,J.M., Hu, W.H., Guo, L., Wing, L.K., Van Eldik, L.J., Watterson, D.M. | J Neuroscience. | 2006 | View |
High-content screening analysis of the p38 pathway: profiling of structurally related p38alpha kinase inhibitors using cell-based assays.
Ross S., Chen, T., Yu, V., Tudor, Y., Zhang, D., Liu, L., Tamayo, N., Dominguez, C., Powers, D. | Assay and Drug Dev Technol. | 2006 | View |
Human amyloid beta - induced neuroinflammation is an early event in neurodegeneration.
Craft, J.M., Watterson, D. M., Van Eldik, L.J. | Glia. | 2006 | View |
Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma.
Khakoo, A.Y., Pati, S., Anderson, S.A., Reid, W., Elshal, M.F., Rovira, I.I., Nguyen, A.T., Malide, D., Combs, C.A., Hall, G., Zhang, J., Raffeld, M., Rogers, T.B., Stetler-Stevenson, W., Frank, J.A., Reitz. M., Finkel, T. | J Exp Med. | 2006 | View |
Identification of Novel Brain Biomarkers.
Laterza, O.F., Modur, V.R., Crimmins, D.L., Olander, J.V., Landt, Y., Lee, J., Ladenson, J.H. | Clin Chem. | 2006 | View |
In vivo characterization of Abeta(40) changes in brain and cerebrospinal fluid using the novel gamma-secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) in the rat.
Best, J.D., Jay, M.T., Otu, F., Churcher, I., Reilly, M., Morentin-Gutierrez, P., Pattison, C., Harrison, T., Shearman, M.S., Atack, J.R. | J Pharmacol Exp Ther. | 2006 | View |
Lasofoxifene enhances vaginal mucus formation without causing hypertrophy and increases estrogen receptor [beta] and androgen receptor in rats.
Wang, X., Simmons, H. A., Salatto, C. T., Cosgrove, P. G., Thompson, D. D. | Menopause. | 2006 | View |
Pharmacokinetics, pharmacodynamics, and safety assessment of palifermin (rHuKGF) in healthy volunteers.
Zia-Amirhosseini, P., Salfi, M., Leese, P., Yates, W., Danilenko, D.M., Ring, B., Cesano, A., Sullivan, J.T. | Clinical Pharmacology & Therapeutics | 2006 | View |
Predictors of elevated nuclear factor-kappaB-dependent genes in obstructive sleep apnea syndrome.
Ryan, S., Taylor, C.T., McNicholas, W.T. | Am J Res and Crit Care Med. | 2006 | View |
Prostacyclin antagonism reduces pain and inflammation in rodent models of hyperalgesia and chronic arthritis.
Pulichino, A.M., Rowland, S., Wu, T., Clark, P., Xu, D., Mathieu, M.C., Riendeau, D., Audoly, L.P. | J Pharmacol Exp Ther. | 2006 | View |
SB-267268, a Nonpeptidic Antagonist of vß3 and vß5 Integrins, Reduces Angiogenesis and VEGF Expression in a Mouse Model of Retinopathy of Prematurity.
Wilkinson-Berka, J. L., Jones, D., Taylor, G., Jaworski, K., Kelly, D. J., Ludbrook, S. B., Willette, R. N., Kumar, S., Gilbert, R.E. | Invest Ophthalmol Vis Sci. | 2006 | View |
Selective leukemic-cell killing by a novel functional class of thalidomide analogs.
Ge, Y., Montano, I., Rustici, G., Freebern, W.J., Haggerty, C.M., Cui, W., Ponciano-Jackson, D., Chandramouli, G.V., Gardner, E.R., Figg, W.D., Abu-Asab, M., Tsokos, M., Jackson, S.H., Gardner. K. | Blood | 2006 | View |
Toll-like receptor (TLR) 2-9 agonists-induced Cytokines & Chemokines: I. Comparison with T cell receptor-induced responses.
Ghosh, T.K., Michelson, D.J., Fink, J., Solberg, J.C., Inglefield, J.R., Hook, D., Gupta, S.K., Gibson, S., Alkan, S.S. | Cell Immunol. | 2006 | View |
Trichomonas vaginalis Lipophosphoglycan Triggers a Selective Upregulation of Cytokines by Human Female Reproductive Tract Epithelial Cells.
Fichorova, R.N., Trifonova, R.T., Gilbert, R.O., Costello, C.E., Hayes, G.R., Lucas, J.J., Singh, B.N. | Infection and Immunity. | 2006 | View |
Assays for high-throughput screening of E2 and E3 ubiquitin ligases.
Kenten J.H., Davydov I.V., Safiran Y.J., Stewart D.H., Oberoi P., Biebuyck, H.A. | Methods in Enzymology. | 2005 | View |
CSF biomarkers for Alzheimer's disease: use in early diagnosis and evaluation of drug treatment.
Blennow, K. | Expert Rev Mol Diagn. | 2005 | View |
FAPP2 is involved in the transport of apical cargo in polarized MDCK cells.
Vieira, O.V., Verkade, P., Manninen, A., Simons, K. | J Cell Biol. | 2005 | View |
Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity.
Wrigley, J.D., Schurov, I., Nunn, E.J., Martin, A.C., Clarke,E.E., Ellis, S., Bonnert, T.P., Shearman, M.S., Beher, D. | J Biol Chem. | 2005 | View |
Identification of coumarin derivatives as a novel class of allosteric MEK1 inhibitors.
Han, S., Zhou, V., Pan, S., Liu, Y., Hornsby, M., McMullan, D., Klock, H.E., Haugen, J., Lesley, S.A., Gray, N., Caldwell, J., Gu, X.J. | Bioorg Med Chem Lett | 2005 | View |
Image-based screening: a technology in transition.
Ramm, P. | Curr Opin Biotechnol. | 2005 | View |
In vitro screening for substrates of the N-end rule-dependent ubiquitylation.
Davydov, I.V., Kenten, J.H., Safiran, Y.J., Nelson, S. Swenerton, R., Oberoi, P., Biebuyck, H.A. | Methods in Enzymology. | 2005 | View |
Pharmacologic profiling of transcriptional targets deciphers promoter logic.
Freebern, W.J., Haggerty, C.M., Montano, I., McNutt, M.C., Collins, I., Graham, A., Chandramouli, G.V.R., Stewart, D.H., Biebuyck, H.A., Taub, D.D., Gardner, K. | Pharmacogenomics J. | 2005 | View |
Quantitative measurement of Changes in Amyloid-beta (40) in the Rat Brain and Cerebrospinal Fluid following Treatment with the gamma-Secretase Inhibitor LY-411575.
Best, J.D., Jay, M.T., Out, F., Ma, J., Nadin, A., Ellis, S., Lewis, H.D., Pattison, C., Reilly, M., Harrison, T., Shearman, M.S., Williamson, T.L., Atack, J.R. et al. | J Pharmacol Exp Ther. | 2005 | View |
Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients.
Willett, C.G., Boucher, Y., Duda, D.G., di Tomaso, E., Munn, L.L., Tong, R.T., Kozin, S.V., Petit, L., Jain, R.K., Chung, D.C., Sahani, D.V., Kalva, S.P., Cohen, K.S., Scadden, D.T., Fischman, A.J., Clark, J.W., Ryan, D.P., Zhu, A.X., Blaszkowsky, L.S., Shellito, P.C., Mino-Kenudson, M., Lauwers, G.Y. | J Clin Oncology. | 2005 | View |
Validation of the Neuroinflammation Cycle as a Drug Discovery Target Using Integrative Chemical Biology and Lead Compound Development with an Alzheimer's Disease-Related Mouse Model.
Hu, W., Ranaivo, H.R., Craft, J.M., Van Eldik, L.J., Watterson, D.M. | Curr Alzheimer's Res. | 2005 | View |
Advancing applications of microarrays.
Pluskal, M.G., Bachmann, J | Drug Discov Today. | 2004 | View |
Assay for ubiquitin ligase activity: high-throughput screen for inhibitors of HDM2.
Davydov, I.V., Woods, D., Safiran, Y.J., Oberoi, P., Fearnhead, H.O., Fang, S., Jensen, J.P., Weissman, A.M., Kenten, J.H., Vousden, K.H. | J Biomol Screen. | 2004 | View |
Assessing cellular protein phosphorylation: high throughput drug discovery technologies.
Russello, S.V. | Assay and Drug Dev Technol. | 2004 | View |
cAMP Detection Methods in HTS: Selecting the best from the rest.
Williams, C. | Nature Reviews: Drug Discovery | 2004 | View |
Clinical and Biological Applications of ECL.
Debad, J.D., Glezer, E.N., Wohlstadter, J.N., Sigal, G.B. | Electrogenerated Chemiluminescence | 2004 | View |
High throughput screening using G-protein coupled receptors as the target.
Wainer, I.W., Beigi, F., Moaddel, R. | Drug Discovery World. | 2003 | View |
Meeting the challenges in screening.
Elands, J., Botwood, M.P. | Drug Discov Today. | 2002 | View |
Chemiluminescence, Electrogenerated
Bard, A.J., Debad, J.D., Leland, J.K., Sigal, G.B., Wilbur, J.L., Wohlstadter, J.N. | Encyclopedia of Analytical Chemistry | 2000 | View |
Enter a Publication Title
Enter the Publication Author(s) | Journal Name | | View |