Immunobiological aspects of therapeutic antibodies and related characterization approaches.

Liu, P.M, Handl, H., Zou, L, Kim, B.
Journal   Curr Opin Drug Discov Devel.
Analytes Measured  
Matrix Tested   Serum
Year   2007
Volume   10
Page Numbers   515-522
Application   Immunogenicity
Antibody therapy is one of the fastest growing areas within the biopharmaceutical field. Immunological properties and biological activity are two of the most critical elements of a therapeutic antibody. The development and validation of analytical approaches provide an appropriate means for antibody immunological characterization, while the emergence of new technologies and advanced biological research and discovery help attain a better understanding of the mechanism of action of antibodies, and therefore facilitate the development of new therapeutic antibodies. This review describes the characteristics of therapeutic antibodies from both immunological and biological perspectives. Recent developments and current implementation of related technologies are discussed.

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