Click image to enlarge
The Inflammation Panel 1 (rat) Kit provides assay-specific components for the quantitative determination of lipocalin-2, thrombospondin 1 (TSP-1), tissue inhibitor of metalloproteinases (TIMP-1), and monocyte chemoattractant protein-1 (MCP-1) in rat serum and plasma.
Increased levels of proinflammatory cytokines play a pivotal role in the pathogenesis of inflammatory diseases such as atherosclerosis, rheumatoid arthritis, and acute and chronic kidney injury. TIMP-1 and lipocalin-2 expression is indicative of inflammatory action following infection, ischemia, and endotoxic insults to the endothelium and stromal matrix. TSP-1, a key activator of TGF-β1, mediates wound healing, cell proliferation, and extracellular matrix formation at sites of injury and bleeding. TSP-1, secreted in response to inflammation, promotes the resolution of the inflammatory process and facilitates phagocytosis or apoptosis of damaged cells, protecting tissues from excessive damage. MCP-1 is uniformly upregulated at sites of vascular disease or injury and is one of the earliest cellular responses to atherogenesis.
-
-
Specifications
-
-
Documentation
-
References
Application(s)
|
|
Cytokines & Chemokines
,
Cardiac Injury
,
Toxicology
,
Kidney Injury
,
Immunology/Inflammation
|
|
Analyte(s)
|
|
MCP-1, NGAL/LCN2, TIMP-1, TSP-1
|
|
Species
|
|
Rat
|
|
Instrument(s)
|
|
SECTOR Imager 2400
,
MESO SECTOR S 600MM
,
SECTOR Imager 6000
,
MESO QuickPlex SQ 120MM
,
MESO QuickPlex SQ 120
,
MESO SECTOR S 600
|
|
Plate Type
|
|
96-well
|
|
Usage Statement
|
|
For Research Use Only. Not for use in diagnostic procedures.
|
|
Storage Condition
|
|
Multi-Component
|
|
Schedule B Code
|
|
3822.19.0000
|
|
Product Inserts
|
|
|
Datasheets
|
|
|
Certificate of analysis
|
|
|
SDS
|
|
|
Title
|
Journal
|
Year
|
|
Galectin-9, a Player in Cytokine Release Syndrome and a Surrogate Diagnostic Biomarker in SARS-CoV-2 Infection
|
|
|
|
Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses
|
|
|
|
Biomarkers of Tuberculosis Severity and Treatment Effect: A Directed Screen of 70 Host Markers in a Randomized Clinical Trial
|
|
|
|
CCL11 is increased in the CNS in chronic traumatic encephalopathy but not in Alzheimer’s disease
|
|
|
|
Kinetics and Biomarkers of Severe Cytokine Release Syndrome after CD19 Chimeric Antigen Receptor-modified T Cell Therapy.
|
|
|
|
View All
|
Customer Service/Orders
Scientific/Technical Support
Instrument Support
Company Headquarters