References | Journal | Year | |
MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo. Hirai, H., Sootome, H., Nakatsuru, Y., Miyama, K., Taguchi, S., Tsujioka, K., Ueno, Y., Hatch, H., Majumder, P.K., Pan, B.S., Kotani, H. | Mol Cancer Ther. | 2010 | View |
MMP-2 and MMP-9 are elevated in spinal cord and skin in a mouse model of ALS. Fang, L., Teuchert, M., Huber-Abel, F., Schattauer, D., Hendrich, C., Dorst, J., Zettlmeissel, H., Wlaschek, M., Scharffetter-Kochanek, K., Kapfer, T., Tumani, H., Ludolph, A.C., Brettschneider, J. | J Neurol Sci. | 2010 | View |
Modeling asthma in macaques: longitudinal changes in cellular and molecular markers. Ayanoglu, G., Desai, B., Fick, R.B. Jr., Grein, J., de Waal Malefyt, R., Mattson, J., McClanahan, T., Olmstead, S., Reece, S.P., Van Scott, M.R., Wardle, R.L. | Eur Respir J. | 2010 | View |
Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease. Coomaraswamy, J., Kilger, E., Wölfing, H., Schäfer, C., Kaeser, S.A., Wegenast-Braun, B.M., Hefendehl, J.K., Wolburg, H., Mazzella, M., Ghiso, J., Goedert, M., Akiyama, H., Garcia-Sierra, F., Wolfer, D.P., Mathews, P.M., Jucker, M. | Proc Natl Acad Sci USA. | 2010 | View |
Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Kounnas, M.Z., Danks, A.M., Cheng, S., Tyree, C., Ackerman, E,, Zhang, X., Ahn, K., Nguyen, P., Comer, D., Mao, L., Yu, C., Pleynet, D., Digregorio, P.J., Velicelebi, G., Stauderman, K.A., Comer, W.T., Mobley, W.C., Li, Y.M., Sisodia, S.S., Tanzi, R.E., Wagner, S.L. | Neuron. | 2010 | View |
Motavizumab for prophylaxis of respiratory syncytial virus in high-risk children: a noninferiority trial. Carbonell-Estrany, X., Simões, E.A., Dagan, R., Hall, C.B., Harris, B., Hultquist, M., Connor, E.M., Losonsky, G.A.; Motavizumab Study Group. | Pediatrics | 2010 | View |
mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy. Song, X., Kusakari, Y., Xiao, C.Y., Kinsella, S.D., Rosenberg, M.A., Scherrer-Crosbie, M., Hara, K., Rosenzweig, A., Matsui, T. | Am J Physiol Cell Physiol. | 2010 | View |
Mumps and ovarian cancer: modern interpretation of an historic association. Cramer, D.W., Vitonis, A.F., Pinheiro, S.P., McKolanis, J.R., Fichorova, R.N., Brown, K.E., Hatchette, T.F., Finn, O.J. | Cancer Causes Control. | 2010 | View |
Natural innate cytokine response to immunomodulators and adjuvants in human precision-cut lung slices. Switalla, S., Lauenstein, L., Prenzler, F., Knothe, S., Forster, C., Fieguth, H.G., Pfennig, O., Schaumann, F., Martin, C., Guzman, C.A., Ebensen, T., Muller, M., Hohlfeld, J.M., Krug, N., Braun, A., Sewald, K. | Toxicol Appl Pharmacol. | 2010 | View |
Neuroinflammation in Lyme neuroborreliosis affects amyloid metabolism. Mattsson, N., Bremell, D., Anckarsater, R., Blennow, K., Anckarsater, H., Zetterberg, H., Hagberg, L. | BMC Neurol. | 2010 | View |
No effect of supplementation with cholecalciferol on cytokines and markers of inflammation in overweight and obese subjects. Jorde, R., Sneve, M., Torjesen, P.A., Figenschau, Y., Gøransson, L.G., Omdal, R. | Cytokine | 2010 | View |
No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days. Witt, K.L., Malarkey, D.E., Hobbs, C.A., Davis, J.P., Kissling, G.E., Caspary, W., Travlos, G., Recio, L. | Environ Mol Mutagen. | 2010 | View |
Novel insights into the cellular mechanisms of the anti-inflammatory effects of NF-kB essential modulator (NEMO) binding domain peptides. Baima, E.T., Guzova, J.A., Mathialagan, S., Nagiec, E.E., Hardy, M.M., Song, L.R., Bonar, S.L., Weinberg, R.A., Selness, S.R., Woodard, S.S., Chrencik, J., Hood, W.F., Schindler, J.F., Kishore, N., Mbalaviele, G. | J Biol Chem. | 2010 | View |
Novel pharmacological MC4R agonists can efficiently activate mutated-MC4R from obese patients with impaired endogenous agonist response. Roubert, P., Dubern, B., Plas, P., Lubrano-Berthelier, C., Alihi, R., Auger, F., Deoliveira, D.B., Dong, J.Z., Basdevant, A., Thurieau, C., Clement, K. | J Endocrinol. | 2010 | View |
Omega-3 fatty acid supplementation improves vascular function and reduces inflammation in obese adolescents. Dangardt, F., Osika, W., Chen, Y., Nilsson, U., Gan, L.M., Gronowitz, E., Strandvik, B., Friberg, P. | Atherosclerosis. | 2010 | View |
Omega-3 fatty acid supplements in women at high risk of breast cancer have dose-dependent effects on breast adipose tissue fatty acid composition. Yee, L.D., Lester, J.L., Cole, R.M., Richardson, J.R., Hsu, J.C., Li, Y., Lehman, A., Belury, M.A., Clinton, S.K. | Am J Clin Nutr. | 2010 | View |
Orally administered bifidobacteria as vehicles for delivery of agents to systemic tumors. Cronin, M., Morrissey, D., Rajendran, S., El Mashad, S.M., van Sinderen, D., O'Sullivan, G.C., Tangney, M. | Mol Ther. | 2010 | View |
Osteopontin Is Required for the Early Onset of High Fat Diet-Induced Insulin Resistance in Mice. Chapman, J., Miles, P.D., Ofrecio, J.M., Neels, J.G., Yu, J.G., Resnik, J.L., Wilkes, J., Talukdar, S., Thapar, D., Johnson, K., Sears, D.D. | PLoS ONE | 2010 | View |
Osteopontin mediates Citrobacter rodentium-induced colonic epithelial cell hyperplasia and attaching-effacing lesions. Wine, E., Shen-Tu, G., Gareau, M.G., Goldberg, H.A., Licht, C., Ngan, B.Y., Sorensen, E.S., Greenaway, J., Sodek, J., Zohar, R., Sherman, P.M. | Am J Pathol. | 2010 | View |
Pharmacology and placental transfer of a human av integrin monoclonal antibody in rabbits. Martin, P. L., Zhou, Z., Van den Bulck, K., Kwok, D., Powers, G., Jiao, Q., Schantz, A., Treacy, G. | Birth Defects Res B Dev Reprod Toxicol. | 2010 | View |
Phase 1 study of AMG 386, a selective angiopoietin 1/2-neutralizing peptibody, in combination with chemotherapy in adults with advanced solid tumors. Mita, A.C., Takimoto, C.H., Mita, M., Tolcher, A., Sankhala, K., Sarantopoulos, J., Valdivieso, M., Wood, L., Rasmussen, E., Sun, Y.N., Zhong, Z.D., Bass, M.B., Le, N., LoRusso, P. | Clinical Cancer Research | 2010 | View |
Phase 1 study of the investigational, oral angiogenesis inhibitor motesanib in Japanese patients with advanced solid tumors. Fujisaka, Y., Yamada, Y., Yamamoto, N., Shimizu, T., Fujiwara, Y., Yamada, K., Tamura, T., Watanabe, H., Sun, Y.N., Bass, M.B., Seki, M. | Cancer Chemother Pharmacol. | 2010 | View |
Phase I and Pharmacokinetic Study of CT-322 (BMS-844203), a Targeted Adnectin Inhibitor of VEGFR-2 Based on a Domain of Human Fibronectin. Tolcher, A.W., Sweeney, CJ., Papadopoulos, K., Patnaik, A., Chiorean, E.G., Mita, A.C., Sankhala, K., Furfine, E., Gokemeijer, J., Iacono, L., Eaton, C., Silver, B.A., Mita, M. | Clin Cancer Res. | 2010 | View |
Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. Batchelor, T.T., Duda, D.G., di Tomaso, E., Ancukiewicz, M., Plotkin, S.R., Gerstner, E., Eichler, A.F., Drappatz, J., Hochberg, F.H., Benner, T., Louis, D.N., Cohen, K.S., Chea, H., Exarhopoulos, A., Loeffler, J.S., Moses, M.A., Ivy, P., Sorensen, A.G., Wen, P.Y., Jain, R.K. | J Clin Oncol. | 2010 | View |
Phase II Study of Neoadjuvant Bevacizumab and Radiotherapy for Resectable Soft Tissue Sarcomas. Yoon, S.S., Duda, D.G., Karl, D.L., Kim, T.M., Kambadakone, A.R., Chen, Y.L., Rothrock, C., Rosenberg, A.E., Nielsen, G.P., Kirsch, D.G., Choy, E., Harmon, D.C., Hornicek, F.J., Dreyfuss, J., Ancukiewicz, M., Sahani, D.V., Park, P.J., Jain, R.K., Delaney, T.F. | Int J Radiat Oncol Biol Phys. | 2010 | View |
Phosphorylation of Tau at S422 is enhanced by Abeta in TauPS2APP triple transgenic mice. Grueninger, F., Bohrmann, B., Czech, C., Ballard, T.M., Frey, J.R., Weidensteiner, C., von Kienlin, M., Ozmen, L. | Neurobiol Dis. | 2010 | View |
Piperidine-derived gamma-secretase modulators. Hall, A., Elliott, R.L., Giblin, G.M., Hussain, I., Musgrave, J., Naylor, A., Sasse, R., Smith, B. | Bioorg Med Chem Lett | 2010 | View |
Placental growth factor neutralising antibodies give limited anti-angiogenic effects in an in vitro organotypic angiogenesis model. Brave, S.R., Eberlein, C., Shibuya, M., Wedge, S.R., Barry, S.T. | Angiogenesis. | 2010 | View |
Polyphenol-enriched apple extract attenuates food allergy in mice. Zuercher, A.W., Holvoet, S., Weiss, M., Mercenier, A. | Clin Exp Allergy. | 2010 | View |
Postnatal PPARd Activation and Myostatin Inhibition Exert Distinct yet Complimentary Effects on the Metabolic Profile of Obese Insulin-Resistant Mice. Bernardo, B.L., Wachtmann, T.S., Cosgrove, P.G., Kuhn, M., Opsahl, A.C., Judkins, K.M., Freeman, T.B., Hadcock, J.R., LeBrasseur, N.K. | PLoS One | 2010 | View |
Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis. Lazar-Molnar, E., Chen, B., Sweeney, K.A., Wang, E.J., Liu, W., Lin, J., Porcelli, S.A., Almo, S.C., Nathenson, S.G., Jacobs, W.R. Jr. | Proc Natl Acad Sci USA. | 2010 | View |
Purinergic receptor-mediated morphological changes in microglia are transient and independent from inflammatory cytokine release. McIlvain, H.B., Ma, L., Ludwig, B., Manners, M.T., Martone, R.L., Dunlop, J., Kaftan, E.J., Kennedy, J.D., Whiteside, G.T. | Eur J Pharmacol. | 2010 | View |
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Hatzivassiliou, G., Song, K., Yen, I., Brandhuber, B.J., Anderson, D.J., Alvarado, R., Ludlam, M.J., Stokoe, D., Gloor, S.L., Vigers, G., Morales, T., Aliagas, I., Liu, B., Sideris, S., Hoeflich, K.P., Jaiswal, B.S., Seshagiri, S., Koeppen, H., Belvin, M., Friedman, L.S., Malek, S. | Nature. | 2010 | View |
Rapamycin Pharmacokinetic and Pharmacodynamic Relationships in Osteosarcoma: A Comparative Oncology Study in Dogs. Paoloni, M.C., Mazcko, C., Fox, E., Fan, T., Lana, S., Kisseberth, W., Vail, D.M., Nuckolls, K., Osborne, T., Yalkowsy, S., Gustafson, D., Yu, Y., Cao, L., Khan, C. | PLoS ONE | 2010 | View |
Rapid Cerebral Amyloid Binding by Abeta Antibodies Infused into beta-Amyloid Precursor Protein Transgenic Mice. Winkler, D.., Abramowski, D., Danner, S., Zurini, M., Paganetti, P., Tolnay, M., Staufenbiel, M. | Biol Psychiatry. | 2010 | View |
Recommendations to qualify biomarker candidates of drug-induced liver injury. Ozer, J.S., Chetty, R., Kenna, G., Koppiker, N., Karamjeet, P., Li, D., Palandra, J., Lanevschi, A., Souberbielle, B.E., Ramaiah, S. | Biomark Med. | 2010 | View |
Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease. Paris, D., Ganey, N.J., Laporte, V., Patel, N.S., Beaulieu-Abdelahad, D., Bachmeier, C., March, A., Ait-Ghezala, G., Mullan, M.J. | J Neuroinflammation. | 2010 | View |
Repeat tuberculin skin testing leads to desensitisation in naturally infected tuberculous cattle which is associated with elevated interleukin-10 and decreased interleukin-1 beta responses. Coad, M., Clifford, D., Rhodes, S.G., Hewinson, R.G., Vordermeier, H.M., Whelan, A.O. | Vet Res. | 2010 | View |
Response of Th17 cells to a citrullinated arthritogenic aggrecan peptide in patients with rheumatoid arthritis. von Delwig, A., Locke, J., Robinson, J.H., Ng, W.F. | Arthritis Rheum. | 2010 | View |
Rheumatoid factor interference in immunogenicity assays for human monoclonal antibody therapeutics. Tatarewicz, S., Miller, J.M., Swanson, S.J., Moxness, M.S. | Journal of Immunological Methods | 2010 | View |
Rho-kinase mediates lysophosphatidic acid-induced IL-8 and MCP-1 production via p38 and JNK pathways in human endothelial cells. Shimada, H., Rajagopalan, L.E. | FEBS Lett. | 2010 | View |
Rose hip exerts anti-diabetic effects via a mechanism involving downregulation of the hepatic lipogenic program. Andersson, U., Henriksson, E., Strom, K., Alenfall, J., Goransson, O., Holm, C. | Am J Physiol Endocrinol Metab. | 2010 | View |
Safety, pharmacokinetics, and pharmacodynamics of AMG 102, a fully human hepatocyte growth factor-neutralizing monoclonal antibody, in a first-in-human study of patients with advanced solid tumors. Gordon, M.S., Sweeney, C.S., Mendelson, D.S., Eckhardt, S.G., Anderson, A., Beaupre, D.M., Branstetter, D., Burgess, T.L., Coxon, A., Deng, H., Kaplan-Lefko, P., Leitch, I.M., Oliner, K.S., Yan, L., Zhu, M., Gore, L. | Clin Cancer Res. | 2010 | View |
Selective and potent raf inhibitors paradoxically stimulate normal cell proliferation and tumor growth. Carnahan, J., Beltran, P.J., Babij, C., Le, Q., Rose, M.J., Vonderfecht, S., Kim, J.L., Smith, A.L., Nagapudi, K., Broome, M.A., Fernando, M., Kha, H., Belmontes, B., Radinsky, R., Kendall, R., Burgess, T.L. | Mol Cancer Ther. | 2010 | View |
Sequestration of the Aß Peptide Prevents Toxicity and Promotes Degradation In Vivo. Luheshi, L.M., Hoyer, W., de Barros, T.P., Hard, I.V., Brorsson, A., Macao, B., Persson, C., Crowther, D.C., Lomas, D.A., Stahl, S., Dobson, C.M., Hard, T. | PLoS Biol. | 2010 | View |
Serum correlates of the placebo effect in irritable bowel syndrome. Kokkotou, E., Conboy, L.A., Ziogas, D.C., Quilty, M.T., Kelley, J.M., Davis, R.B., Lembo, A.J., Kaptchuk, T.J. | Neurogastroenterol Motil. | 2010 | View |
Serum levels of a subset of cytokines show high interindividual variability and are not altered in rats transgenic for Huntington´s disease. Nguyen, H.P., Bjorkqvist, M., Bode, F.J., Stephan, M., von Horsten, S. | PLoS Curr. | 2010 | View |
Sex and ethnic differences in 47 candidate proteomic markers of cardiovascular disease: the mayo clinic proteomic markers of arteriosclerosis study. Kim, C.X., Bailey, K.R., Klee, G.G., Ellington, A.A., Liu, G., Mosley, T.H. Jr, Rehman, H., Kullo, I.J. | Cancer Chemother Pharmacol. | 2010 | View |
Shorter dosing intervals of sublingual immunotherapy lead to more efficacious treatment in a mouse model of allergic inflammation. Rask, C , Brimnes, J., Lund, K. | Scandinavian Journal of Immunology. | 2010 | View |
Short-term IL-1beta blockade reduces monocyte CD11b integrin expression in an IL-8 dependent fashion in patients with type 1 diabetes. Sanda, S., Bollyky, J., Standifer, N., Nepom, G., Hamerman, J.A., Greenbaum, C. | Clin Immunol. | 2010 | View |