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Pharmacology of AMG 181, a human anti-α(4) β(7) antibody that specifically alters trafficking of gut-homing T cells.
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Phase I study of Ofatumumab, a human anti-CD20 antibody, in Japanese patients with relapsed or refractory chronic lymphocytic leukemia and small lymphocytic lymphoma.
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Phase I study of Dovitinib (TKI258), an oral FGFR, VEGFR, and PDGFR inhibitor, in advanced or metastatic renal cell carcinoma.
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Phase II study evaluating 2 dosing schedules of oral Foretinib (GSK1363089), cMET/VEGFR2 inhibitor, in patients with metastatic gastric cancer.
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Phase II study of a neutrophil elastase inhibitor (AZD9668) in patients with bronchiectasis.
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Physical activity is associated with retained muscle metabolism in human myotubes challenged with palmitate.
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PI3K-δ and PI3K-γ Inhibition by IPI-145 Abrogates Immune Responses and Suppresses Activity in Autoimmune and Inflammatory Disease Models.
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Poor sleep quality potentiates stress-induced cytokine reactivity in postmenopausal women with high visceral abdominal adiposity.
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Population pharmacokinetics of belimumab following intravenous administration in patients with systemic lupus erythematosus.
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Preclinical Evaluation of the Toxicological Effects of a Novel Constrained Ethyl Modified Antisense Compound Targeting Signal Transducer and Activator of Transcription 3 in Mice and Cynomolgus Monkeys.
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Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells.
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Proteasome inhibition induces stress kinase dependent transport deficits - Implications for Alzheimer's disease.
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Puerperal mastitis: a reproductive event of importance affecting anti-mucin antibody levels and ovarian cancer risk.
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Purification of monoclonal antibodies by hydrophobic interaction chromatography under no-salt conditions.
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Quinine controls body weight gain without affecting food intake in male C57BL6 mice.
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Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults.
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Relationship between Carotid Intima Media Thickness and Helminth Infections on Flores Island, Indonesia.
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Renal inflammatory markers during the onset of hypertension in spontaneously hypertensive rats.
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Reproductive toxicity of denosumab in cynomolgus monkeys.
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Requirement of apoptosis-inducing kinase 1 for the induction of bronchial asthma following stimulation with ovalbumin.
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Resveratrol protects against atherosclerosis, but does not add to the antiatherogenic effect of atorvastatin, in APOE*3-Leiden.CETP mice.
Berbée JF, Wong MC, Wang Y, van der Hoorn JW, Khedoe PP, van Klinken JB, Mol IM, Hiemstra PS, Tsikas D, Romijn JA, Havekes LM, Princen HM, Rensen PC. | J Nutr Biochem. 2013 Aug;24(8):1423-30 | 2013 | View |
Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rats.
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S49076 is a novel kinase inhibitor of MET, AXL and FGFR with strong preclinical activity alone and in association with bevacizumab.
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Safety and Immunogenicity of a Live Attenuated RSV Vaccine in Healthy RSV-Seronegative Children 5 to 24 Months of Age.
Malkin E, Yogev R, Abughali N, Sliman J, Wang CK, Zuo F, Yang CF, Eickhoff M, Esser MT, Tang RS, Dubovsky F. | PLoS One | 2013 | View |
Safety, pharmacokinetics, and pharmacodynamic effects of a selective TGR5 agonist, SB-756050, in type 2 diabetes.
Hodge RJ, Lin J, Johnson LSV, Gould EP, Bowers GD, Nunex DJ. | Clinical Pharmacology in Drug Development | 2013 | View |
Safety, tolerability and pharmacokinetics of a human anti-interleukin-13 monoclonal antibody (CNTO 5825) in an ascending single-dose first-in-human study.
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Salivary cytokines in healthy adolescent girls: Intercorrelations, stability, and associations with serum cytokines, age, and pubertal stage.
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SAR investigations on a novel class of gamma-secretase modulators based on a unique scaffold
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Sarcoidosis, alveolar β-Actin and pulmonary fibrosis.
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Secretory leukocyte protease inhibitor: A pivotal mediator of anti-inflammatory responses in acetaminophen induced acute liver failure.
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Self-rated health among pregnant women: associations with objective health indicators, psychological functioning, and serum inflammatory markers.
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Serum folate receptor alpha, mesothelin and megakaryocyte potentiating factor in ovarian cancer: association to disease stage and grade and comparison to CA125 and HE4.
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Serum levels of IL-6 and IL-1β can predict the efficacy of gemcitabine in patients with advanced pancreatic cancer.
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Serum lysyl oxidase like-2 levels and idiopathic pulmonary fibrosis disease progression.
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Christian LM, Porter K, Karlsson E, Schultz-Cherry S, Iams JD. | Am J Reprod Immunol. | 2013 | View |
Shedding LIGHT (TNFSF14) on the tumor microenvironment of colorectal cancer liver metastases.
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SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes.
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Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity.
Kruppa AJ, Ott S, Chandraratna DS, Irving JA, Page RM, Speretta E, Camargo LM, Marciniak SJ, Lomas DA, Crowther DC. | BBA - Molecular Basis of Disease, | 2013 | View |
Suppression of DHT-induced paracrine stimulation of endothelial cell growth by estrogens via prostate cancer cells.
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Susceptibility of adult and senescent Brown Norway rats to repeated ozone exposure: an assessment of behavior, serum biochemistry and cardiopulmonary function.
Gordon CJ, Jarema KA, Lehmann JR, Ledbetter AD, Schladweiler MC, Schmid JE, Ward WO, Kodavanti UP, Nyska A, MacPhail RC. | Inhal Toxicol | 2013 | View |
T Cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia.
Fogli LK, Sundrud MS, Goel S, Bajwa S, Jensen K, Derudder E, Sun A, Coffre M, Uyttenhove C, Van Snick J, Schmidt-Supprian M, Rao A, Grunig G, Durbin J, Casola SS, Rajewsky K, Koralov SB. | J Immunol. | 2013 | View |
Targeting IGF-IR with ganitumab inhibits tumorigenesis and increases durability of response to androgen-deprivation therapy in VCaP prostate cancer xenografts.
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T-cell-dependent antibody responses in the rat: Forms and sources of keyhole limpet hemocyanin matter.
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