| References | Journal | Year | |
Genetic Deletion and Pharmacological Inhibition of Phosphodiesterase 10A Protects Mice From Diet-Induced Obesity and Insulin Resistance.
Nawrocki AR, Rodriguez CG, Toolan DM, Price O, Henry M, Forrest G, Szeto D, Keohane CA, Pan Y, Smith KM, Raheem IT, Cox CD, Hwa J, Renger JJ, Smith SM. | Diabetes | 2014 | View |
Beneficial effects of parenteral GLP-1 delivery by cell therapy in insulin-deficient streptozotocin diabetic mice.
Vasu S, Moffett RC, McCluskey JT, Hamid MH, Irwin N, Flatt PR. | Gene Ther. | 2013 | View |
Caloric restriction favorably impacts metabolic and immune/inflammatory profiles in obese mice but curcumin/piperine consumption adds no further benefit.
Wang J, Vanegas SM, Du X, Noble T, Zingg JM, Meydani M, Meydani SN, Wu D. | Nutr Metab (Lond) | 2013 | View |
Diacylglycerol Acyltransferase-1 (DGAT1) inhibition perturbs postprandial gut hormone release.
Lin HV, Chen D, Shen Z, Zhu L, Ouyang X, Vongs A, Kan Y, Levorse JM, Kowalik EJ Jr, Szeto DM, Yao X, Xiao J, Chen S, Liu J, Garcia-Calvo M, Shin MK, Pinto S. | PLoS One | 2013 | View |
Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency.
Mokadem M, Zechner JF, Margolskee RF, Drucker DJ, Aguirre V. | Molecular Metabolism | 2013 | View |
Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo.
Rezania A, Bruin JE, Xu J, Narayan K, Fox JK, O'Neil JJ, Kieffer TJ. | Stem Cells | 2013 | View |
Fibroblast growth factor 21 mediates specific glucagon actions.
Habegger KM, Stemmer K, Cheng C, Müller TD, Heppner KM, Ottaway N, Holland J, Hembree JL, Smiley D, Gelfanov V, Krishna R, Arafat AM, Konkar A, Belli S, Kapps M, Woods SC, Hofmann SM, D'Alessio D, Pfluger PT, Perez-Tilve D, Seeley RJ, Konishi M, et al. | Diabetes | 2013 | View |
Glucagon-like peptide-1 receptor agonist treatment reduces beta cell mass in normoglycaemic mice.
Ellenbroek JH, Töns HA, Westerouen van Meeteren MJ, de Graaf N, Hanegraaf MA, Rabelink TJ, Carlotti F, de Koning EJ. | Diabetologia | 2013 | View |
GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes.
Nohr MK, Pedersen MH, Gille A, Egerod KL, Engelstoft MS, Husted AS, Sichlau RM, Grunddal KV, Seier Poulsen S, Han S, Jones RM, Offermanns S, Schwartz TW. | Endocrinology | 2013 | View |
High-fat feeding rapidly induces obesity and lipid derangements in C57BL/6N mice.
Podrini C, Cambridge EL, Lelliott CJ, Carragher DM, Estabel J, Gerdin AK, Karp NA, Scudamore CL; Sanger Mouse Genetics Project, Ramirez-Solis R, White JK. | Mamm Genome | 2013 | View |
Inhibition of nuclear factor of activated T-cells (NFAT) suppresses accelerated atherosclerosis in diabetic mice.
Zetterqvist AV, Berglund LM, Blanco F, Garcia-Vaz E, Wigren M, Dunér P, Andersson AM, To F, Spegel P, Nilsson J, Bengtsson E, Gomez MF. | PLoS One | 2013 | View |
Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor.
Diakogiannaki E, Pais R, Tolhurst G, Parker HE, Horscroft J, Rauscher B, Zietek T, Daniel H, Gribble FM, Reimann F. | Diabetologia | 2013 | View |
Quinine controls body weight gain without affecting food intake in male C57BL6 mice.
Cettour-Rose P, Bezençon C, Darimont C, le Coutre J, Damak S. | BMC Physiol | 2013 | View |
2-Aminoadipic acid is a biomarker for diabetes risk.
Wang TJ, Ngo D, Psychogios N, Dejam A, Larson MG, Vasan RS, Ghorbani A, O'Sullivan J, Cheng S, Rhee EP, Sinha S, McCabe E, Fox CS, O'Donnell CJ, Ho JE, Florez JC, Magnusson M, Pierce KA, Souza AL, Yu Y, Carter C, Light PE, Melander O, Clish CB, Gerszten R | J Clin Invest. | 2012 | View |
Beneficial effects of the novel cholecystokinin agonist (pGlu-Gln)-CCK-8 in mouse models of obesity/diabetes.
Irwin N, Frizelle P, Montgomery IA, Moffett RC, O'Harte FP, Flatt PR. | Diabetologia. | 2012 | View |
Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms.
Lin HV, Frassetto A, Kowalik EJ Jr, Nawrocki AR, Lu MM, Kosinski JR, Hubert JA, Szeto D, Yao X, Forrest G, Marsh DJ. | PLoS One. | 2012 | View |
Chemical cholecystokinin receptor activation protects against obesity-diabetes in high fat fed mice and has sustainable beneficial effects in genetic ob/ob mice.
Irwin N, Montgomery IA, Moffett RC, Flatt PR. | Biochem Pharmacol. | 2012 | View |
Choline deficiency attenuates body weight gain and improves glucose tolerance in ob/ob mice.
Wu G, Zhang L, Li T, Lopaschuk G, Vance DE, Jacobs RL. | J Obes. | 2012 | View |
Diet-induced obesity significantly increases the severity of post-traumatic arthritis in mice.
Louer CR, Furman BD, Huebner JL, Kraus VB, Olson SA, Guilak F. | Arthritis Rheum. | 2012 | View |
Dissociation of inositol requiring enzyme (IRE1α)-mediated JNK activation from hepatic insulin resistance in conditional X-box binding protein-1 (XBP1) knockout mice.
Jurczak, M.J., Lee, A.H., Jornayvaz, F.R., Lee, H.Y., Birkenfeld, A.L., Guigni, B.A., Kahn, M., Samuel, V.T., Glimcher, L.H., Shulman, G.I. | J Biol Chem. 287(4):2558-67 | 2012 | View |
Functionally convergent white adipogenic progenitors of different lineages participate in a diffused system supporting tissue regeneration.
Lemos DR, Paylor B, Chang C, Sampaio A, Underhill TM, Rossi FM. | Stem Cells | 2012 | View |
GIP-overexpressing mice demonstrate reduced diet-induced obesity and steatosis, and improved glucose homeostasis.
Kim S, Nian C, Karunakaran S, Clee SM, Isales CM, McIntosh CHS. | PLoS One | 2012 | View |
Hepatic Deletion of SIRT1 Decreases Hepatocyte Nuclear Factor 1alpha/Farnesoid X Receptor Signaling and Induces Formation of Cholesterol Gallstones in Mice.
Purushotham A, Xu Q, Lu J, Foley JF, Yan X, Kim DH, Kemper JK, Li X. | Mol Cell Biol. | 2012 | View |
Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase.
Talukdar S, Oh DY, Bandyopadhyay G, Li D, Xu J, McNelis J, Lu M, Li P, Yan Q, Zhu Y, Ofrecio J, Lin M, Brenner MB, Olefsky JM. | Nat Med. | 2012 | View |
Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release – potential insight into mechanism of action.
Liu J, Gorski J, Gold SJ, Chen D, Chen S, Forrest G, Itoh Y, Marsh D, McLaren D, Shen Z, Sonatore L, Carballo-Jane E, Craw S, Guan X, Karanam B, Sakaki J, Szeto D, Tong X, Xiao J, Yoshimoto R, Yu H, Balkovec J, Pinto S. | Obesity | 2012 | View |