Metabolic-Related Research Applications

The complex pathologies of diabetes, cardiovascular disease, and metabolic syndrome have driven an increased demand for quantitative measurement of biomarkers associated with these disease states. Obesity is directly related to increased risk for diabetes, hypertension, atherosclerosis, and metabolic syndrome. Novel proteomic technologies have helped define key serum biomarkers produced in the gut and adipose tissue and altered in abundance in disease states.

MSD provides solutions to support and simplify your metabolic research needs. We offer singleplex and multiplex assays to measure biomarkers such as GLP-1, glucagon, insulin, and leptin, in a variety of formats.

U-PLEX: MSD’s Most Flexible Assay Platform

The flexibility of the U-PLEX platform empowers you to make personalized multiplex assay combinations. Now you can build and run your multiplex assay at your convenience without any additional equipment or time-consuming assay development.

Discover new combinations with the quality and performance you expect from MSD.

 

U-PLEX Assay Designer
Use the U-PLEX Assay Designer to create custom panels from a selection of MSD assays, your own antibodies, or a combination of both. Choose 96- or 384-well formats.

U-PLEX Combinations for Metabolic Research

U-PLEX Combinations represent popular combinations of assays, grouped into separate catalog numbers for ordering convenience.

Species	Name	Catalog Number	Assays
Human	Diabetes Combo 1	K15274K	C‑Peptide, GIP (total), GLP‑1 (total), Glucagon, Insulin, Leptin, PYY (total)
Human	Diabetes Combo 2	K15275K	C‑Peptide, GIP (total), GLP‑1 (active), Glucagon, Insulin, Leptin, PYY (total)
Human	Adipokine Combo 1	K15276K	BDNF, β‑NGF, IL‑1β, IL‑6, IL‑8, IL‑10, Insulin, Leptin, MCP‑1, TNF‑α
Human	Obesity Combo 1	K15277K	BDNF, FGF‑21, Ghrelin (total), Glucagon, Leptin
Human	Obesity Combo 2	K15278K	C‑Peptide, FGF‑23, Ghrelin (total), GLP‑1 (total), Insulin, Leptin, PYY (total)
Human	Microbiome Combo 1	K15441K NEW	Ghrelin (total), GLP‑1 (total), Glucagon, Insulin, Leptin, PP, PYY (total)
Human	Metabolic Combo 1	K15281K	BAFF, BDNF, β‑NGF, C‑Peptide, FGF‑21, FGF‑23, FSH, Ghrelin (active), Ghrelin (total), GIP (active), GIP (inactive), GIP (total), GLP‑1 (active), GLP‑1 (inactive), GLP‑1 (total), Glucagon, Insulin, Leptin, LH, PP, Proinsulin, PYY (total)
Human	Metabolic Group 1	K15280K	BAFF, BDNF, β NGF, C Peptide, CTACK (CCL27), ENA 78 (CXCL5), Eotaxin (CCL11), Eotaxin 2 (CCL24), Eotaxin 3 (CCL26), EPO, FGF 21, FGF 23, FLT3L, FSH, Fractalkine (CX3CL1), G CSF, Ghrelin (active), Ghrelin (total), GIP (active), GIP (inactive), GIP (total), GLP 1 (active), GLP 1 (inactive), GLP 1 (total), Glucagon, GM CSF, GRO α (CXCL1), I 309 (CCL1), IFN α2a, IFN β, IFN γ, IL 1α, IL 1β, IL 1RA, IL 2, IL 2Rα, IL 3, IL 4, IL 5, IL 6, IL 7, IL 8 (CXCL8), IL 9, IL 10, IL 12/IL 23p40, IL 12p70, IL 13, IL 15, IL 16, IL 17A, IL 17A/F, IL 17C, IL 17D, IL 17E/IL 25, IL 17F, IL 18, IL 21, IL 22, IL 23, IL 27, IL 29/IFN λ1, IL 31, IL 33, Insulin, IP 10 (CXCL10), Leptin, LH, MCP 1 (CCL2), MCP 2 (CCL8), MCP 4 (CCL13), M CSF, MDC (CCL22), MIF, MIP 1α (CCL3), MIP 5, PP, Proinsulin, PYY (total), SDF 1α (CXCL12), TARC (CCL17), TNF α, TNF β, TPO, TRAIL, TSLP, VEGF A, YKL 40
Mouse	Adipokine Combo 1	K15299K	BDNF, IL-1β, IL-6, IL-10, Insulin, Leptin, MCP-1, TNF-α
Mouse	Diabetes Combo 1	K15298K	C-Peptide, GLP-1 (total), Glucagon, Insulin, Leptin, PYY (total)
Mouse	Gut Hormone Combo 1	K15307K	Ghrelin (active), GLP-1 (active), Glucagon, Insulin, Leptin, PYY (total)
Mouse	Metabolic 2-Plex Combo 1	K15302K	Leptin, Insulin
Mouse	Metabolic 2-Plex Combo 2	K15303K	Insulin, Glucagon
Mouse	Metabolic 3-Plex Combo 1	K15304K	GLP-1 (total), Glucagon, Insulin
Mouse	Metabolic 3-Plex Combo 2	K15305K	GLP-1 (active), Glucagon, Insulin
Mouse	Metabolic Combo 1	K15297K	BDNF, C-Peptide, FGF-21, Ghrelin (active), Ghrelin (total), GLP-1 (active), GLP-1 (inactive), GLP-1 (total), Glucagon, Insulin, Leptin, PYY (total), BAFF
Mouse	Metabolic Group 1	K15317K	BAFF, BCA-1/BLC, BDNF, CD40, C-Peptide, Eotaxin, EPO, FGF-21, Ghrelin (active), Ghrelin (total), GLP-1 (active), GLP-1 (inactive), GLP-1 (total), Glucagon, GM-CSF, IFN-α, IFN-β, IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-17A/F, IL-17C, IL-17E/IL-25, IL-17F, IL-21, IL-22, IL-23, IL-27p28/IL-30, IL-31, IL-33, Insulin, IP-10, KC, Leptin, MCP-1, MCP-5/CCL12, MDC, MIP-1α, MIP-1β, MIP-2, MIP-3α, MMP-9 (total), PYY (total), RANTES, TARC, TNF-α, VEGF-A
Mouse	Metabolic Hormone Combo 1	K15306K	C-Peptide , Ghrelin (active), GLP-1 (active), Glucagon, IL-6, Insulin, Leptin, MCP-1, PYY (total), TNF-α
Mouse	Obesity Combo 1	K15300K	BDNF, FGF-21, Ghrelin (total), Glucagon, Leptin
Mouse	Obesity Combo 2	K15301K	C-Peptide, Ghrelin (total), GLP-1 (total), Insulin, Leptin, PYY (total)
Rat	Diabetes Combo 1	K15309K	C-Peptide, GLP-1 (total), Glucagon, Insulin, Leptin, PYY (total)
Rat	Metabolic 2-Plex Combo 1	K15312K	Leptin, Insulin
Rat	Metabolic 2-Plex Combo 2	K15313K	Insulin, Glucagon
Rat	Metabolic 3-Plex Combo 1	K15314K	GLP-1 (total), Glucagon, Insulin
Rat	Metabolic 3-Plex Combo 2	K15315K	GLP-1 (active), Glucagon, Insulin
Rat	Metabolic Combo 1	K15308K	BDNF, C-Peptide, FGF-21, Ghrelin (active), Ghrelin (total), GLP-1 (active), GLP-1 (inactive), GLP-1 (total), Glucagon, Insulin, Leptin, PYY (total)
Rat	Metabolic Hormone Combo 1	K15316K	C-Peptide , Ghrelin (active), GLP-1 (active), Glucagon, Insulin, Leptin, PYY (total)
Rat	Obesity Combo 1	K15310K	BDNF, FGF-21, Ghrelin (total), Glucagon, Leptin
Rat	Obesity Combo 2	K15311K	C-Peptide, Ghrelin (total), GLP-1 (total), Insulin, Leptin, PYY (total)

NEW Metabolic-Related Assays

Individual assays can be configured into customized multiplex combinations of your choice in either 96- or 384-well formats.

Combine MSD assays with your own assays or R-PLEX Antibody Sets for a truly custom multiplex.